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1
APP deficiency did not affect the mRNA level of <i>Scn8a</i> in cerebellar PCs.
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L7 promoter-driven Cre recombinase expression is restricted to PCs in the cerebellar cortex.
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4
Nav1.6 mediated the deficits of PC firing and motor function in APP-null mice.
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Exogenous APP expression restored the Nav1.6 currents and ameliorated the abnormalities in the firing patterns of PCs of APP-null mice.
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7
Antibody validation for Nav1.6 and Nav1.1-EGFP in transfected HEK293 cells.
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8
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9
APP deficiency does not alter PC development or induce degeneration.
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10
APP deficiency selectively reduces Nav1.6-mediated Na<sup>+</sup> currents in cerebellar PCs.
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11
Nav1.6 Mediates most of the persistent and resurgent sodium currents in cerebellar PCs.
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12
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14
Cerebellar Purkinje cell (PC)-specific amyloid precursor protein (APP) expression modulates motor function.
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15
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16
Validation of Nav1.6 and Nav1.1 contributions to sodium currents in PCs.
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17
Full-length APP is required for the rescue of motor deficit in APP-null mice.
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18