Tonic inhibition reduces LTP amplitude but maintains proximal potentiation and frequency dependence. Bằng Nicholas Hananeia (22683665)

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Schematic of added myelinated axon. Bằng Nicholas Hananeia (22683665)

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Parameter values for four-pathway synaptic plasticity model. Bằng Nicholas Hananeia (22683665)

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Biphasic stimulus shows different frequency dependence to monophasic stimulus. Bằng Nicholas Hananeia (22683665)

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Modelling framework for TMS-induced long-term synaptic plasticity. Bằng Nicholas Hananeia (22683665)

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Pharmacology in silico: rMS-induced LTP depends on dendritic sodium and calcium through voltage-gated calcium channels, as well as synaptic NMDA channels. Bằng Nicholas Hananeia (22683665)

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Voltage traces from local electrical and rMS TBS, recorded at the soma and distal apical tuft, account for the outcomes of synaptic plasticity. Bằng Nicholas Hananeia (22683665)

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The synaptic plasticity model reproduces distal LTP for local electric TBS and predicts proximal and distal LTP for rMS TBS. Bằng Nicholas Hananeia (22683665)

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Ion channels and membrane properties. Bằng Nicholas Hananeia (22683665)

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The modelling framework for synaptic plasticity replicates proximal LTP induced by 10 Hz rMS protocol and predicts increasing LTP with higher stimulation frequency. Bằng Nicholas Hananeia (22683665)

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Unifying four-pathway model of long-term synaptic plasticity reproduces frequency dependence of synaptic changes in hippocampal CA1 pyramidal cells evoked by local electrical Schaf... Bằng Nicholas Hananeia (22683665)

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Presynaptic and postsynaptic weights change monotonically linearly over stimulus duration. Bằng Nicholas Hananeia (22683665)

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HippoUnit test error scores show the validity of the CA1 pyramidal cell model. Bằng Nicholas Hananeia (22683665)

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Plasticity model reproduces an additional synaptic plasticity paradigm using pairings of presynaptic spikes or bursts of spikes with postsnyaptic spikes or bursts of spikes. Bằng Nicholas Hananeia (22683665)

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LTP induced by 10 Hz rMS rapidly increases after crossing firing threshold, but quickly saturates. Bằng Nicholas Hananeia (22683665)

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Distal LTP induced by simulated rMS is sustained by sodium dendritic spikes but less affected by inhibition than local electrical stimulation. Bằng Nicholas Hananeia (22683665)

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Plasticity model shows continued linear increases in LTP induction at higher frequencies. Bằng Nicholas Hananeia (22683665)

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TMS pulse propagates beginning in the axon terminal, subsequently activating soma and dendrites. Bằng Nicholas Hananeia (22683665)

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