Discovery of therapeutic compounds targeting brain metastasis-associated tumor cells (MBMATCs) in high MBM-Index melanoma. Dahkki Jingxin Zeng (18773484)

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Single cell RNA-seq and snRNA-seq profiling of the PTs (primary melanoma), ECMs (extracranial melanoma metastases) and MBMs (melanoma brain metastases) environments. Dahkki Jingxin Zeng (18773484)

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Marker genes in melanoma tumor cells across PT, ECM and MBM by sc/snRNA-seq. Dahkki Jingxin Zeng (18773484)

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scRNA-seq and snRNA-seq profiling of 26 melanoma samples. Dahkki Jingxin Zeng (18773484)

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AXL and MITF signature genes. Dahkki Jingxin Zeng (18773484)

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The MBM-Index showed no significant correlation with clinicopathological features. Dahkki Jingxin Zeng (18773484)

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Interaction between MBMATCs and the immune microenvironment. Dahkki Jingxin Zeng (18773484)

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Pseudotime trajectory analysis of melanoma clusters Mela4 and Mela5. Dahkki Jingxin Zeng (18773484)

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Identification of therapeutic drugs with high drug sensitivity for brain metastasis-associated tumor cells (MBMATCs) and high-brain metastasis (MBM) index patients. Dahkki Jingxin Zeng (18773484)

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The enriched pathway by all transcripts differentially expressed between MBMATCs and other tumor cells, and between MBM-High and MBM-Low groups. Dahkki Jingxin Zeng (18773484)

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Immune landscape and CD8⁺ T cell transition states in PTs, ECMs and MBMs. Dahkki Jingxin Zeng (18773484)

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Immune cells profiling in PTs, ECMs and MBMs. Dahkki Jingxin Zeng (18773484)

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Identification of melanoma brain metastasis-associated tumor cell subpopulations (MBMATCs). Dahkki Jingxin Zeng (18773484)

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Samples & cell type composition in melanoma tumor cells. Dahkki Jingxin Zeng (18773484)

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Samples & cell type composition in sc/snRNA-seq. Dahkki Jingxin Zeng (18773484)

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Tumor cell-specific transcriptomic features across PTs, ECMs and MBMs. Dahkki Jingxin Zeng (18773484)

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Fluvastatin inhibits the migration of melanoma A375 cells in a wound healing assay. Dahkki Jingxin Zeng (18773484)

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The MBM-Index as an independent predictor of overall survival (OS) in melanoma. Dahkki Jingxin Zeng (18773484)

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