Immunological Profile of Patients with Rheumatoid Arthritis and Asthma
Introduction: The aim of this study was to investigate cytokine profiles in patients with both rheumatoid arthritis (RA) and bronchial asthma (BA). Methods: We studied 25 patients with RA, 25 with BA, and 25 with both RA and BA (BARA). A respiratory questionnaire was completed by all the patients, t...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , , , |
| التنسيق: | article |
| منشور في: |
2025
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| الوصول للمادة أونلاين: | http://hdl.handle.net/11675/14435 https: |
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| _version_ | 1870679728015278080 |
|---|---|
| author | Almutairi, Sana S. |
| author2 | Azizieh, Fawaz Y. Al-Herz, Adeeba A. Al-Shemary, Tahany E. Alsaber, Ahmed R. Raghupathy, Raj |
| author2_role | author author author author author |
| author_facet | Almutairi, Sana S. Azizieh, Fawaz Y. Al-Herz, Adeeba A. Al-Shemary, Tahany E. Alsaber, Ahmed R. Raghupathy, Raj |
| author_role | author |
| dc.creator.none.fl_str_mv | Almutairi, Sana S. Azizieh, Fawaz Y. Al-Herz, Adeeba A. Al-Shemary, Tahany E. Alsaber, Ahmed R. Raghupathy, Raj |
| dc.date.none.fl_str_mv | 2025-08-12 2026-06-03T09:35:39Z 2026-06-03T09:35:39Z |
| dc.identifier.none.fl_str_mv | 10.1159/000547902 http://hdl.handle.net/11675/14435 https: www.scopus.com/pages/publications/105017543314 |
| dc.publisher.none.fl_str_mv | S. Karger AG |
| dc.relation.none.fl_str_mv | Institutional Research and Effectiveness Medical Principles and Practice |
| dc.title.none.fl_str_mv | Immunological Profile of Patients with Rheumatoid Arthritis and Asthma |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Introduction: The aim of this study was to investigate cytokine profiles in patients with both rheumatoid arthritis (RA) and bronchial asthma (BA). Methods: We studied 25 patients with RA, 25 with BA, and 25 with both RA and BA (BARA). A respiratory questionnaire was completed by all the patients, they underwent spirometry, and their production patterns of selected T helper (Th)1, Th2, and Th17 cytokines were assessed. Results: BA patients had spirometry findings similar to BARA patients, while RA patients had normal spirometry. BA patients produced significantly higher levels of interleukin (IL)-5 (p = 0.03) and IL-10 (p = 0.03) than patients with RA. Median levels of IL-17A and IL-17F and interferon (IFN)-? were higher (p = 0.001, 0.004, and 0.04) in RA patients than in BA patients. No differences were seen in the levels of cytokines produced by BA patients compared to BARA patients. IL-4 and IL-10 levels were higher (p = 0.04 and 0.03) in BARA patients than in RA patients, while levels of IL-17A and IFN-? were higher (p = 0.037 and 0.009, respectively) in RA patients than in BARA patients. Ratios of Th1/Th2 and Th17/Th2 cytokines in most combinations were different between RA and BA, and between RA and BARA, but were similar in BA and BARA. Conclusions: Patients with both BA and RA have a Th2-dominant cytokine profile unlike patients with RA alone. These observations contribute to a better understanding of the immunopathogenesis of these diseases and to the management of patients using cytokine-based therapies. |
| format | article |
| id | AUKR_29b85dbebf4e85daa1cc3e46f35c2fd1 |
| identifier_str_mv | 10.1159/000547902 www.scopus.com/pages/publications/105017543314 |
| network_acronym_str | AUKR |
| network_name_str | AU Kuwait Rep |
| oai_identifier_str | oai:dspace.auk.edu.kw:11675/14435 |
| publishDate | 2025 |
| publisher.none.fl_str_mv | S. Karger AG |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Immunological Profile of Patients with Rheumatoid Arthritis and AsthmaAlmutairi, Sana S. Azizieh, Fawaz Y. Al-Herz, Adeeba A. Al-Shemary, Tahany E.Alsaber, Ahmed R.Raghupathy, RajIntroduction: The aim of this study was to investigate cytokine profiles in patients with both rheumatoid arthritis (RA) and bronchial asthma (BA). Methods: We studied 25 patients with RA, 25 with BA, and 25 with both RA and BA (BARA). A respiratory questionnaire was completed by all the patients, they underwent spirometry, and their production patterns of selected T helper (Th)1, Th2, and Th17 cytokines were assessed. Results: BA patients had spirometry findings similar to BARA patients, while RA patients had normal spirometry. BA patients produced significantly higher levels of interleukin (IL)-5 (p = 0.03) and IL-10 (p = 0.03) than patients with RA. Median levels of IL-17A and IL-17F and interferon (IFN)-? were higher (p = 0.001, 0.004, and 0.04) in RA patients than in BA patients. No differences were seen in the levels of cytokines produced by BA patients compared to BARA patients. IL-4 and IL-10 levels were higher (p = 0.04 and 0.03) in BARA patients than in RA patients, while levels of IL-17A and IFN-? were higher (p = 0.037 and 0.009, respectively) in RA patients than in BARA patients. Ratios of Th1/Th2 and Th17/Th2 cytokines in most combinations were different between RA and BA, and between RA and BARA, but were similar in BA and BARA. Conclusions: Patients with both BA and RA have a Th2-dominant cytokine profile unlike patients with RA alone. These observations contribute to a better understanding of the immunopathogenesis of these diseases and to the management of patients using cytokine-based therapies.S. Karger AG2026-06-03T09:35:39Z2026-06-03T09:35:39Z2025-08-12Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10.1159/000547902http://hdl.handle.net/11675/14435https:www.scopus.com/pages/publications/105017543314Institutional Research and EffectivenessMedical Principles and Practiceoai:dspace.auk.edu.kw:11675/144352026-06-09T12:14:55Z |
| spellingShingle | Immunological Profile of Patients with Rheumatoid Arthritis and Asthma Almutairi, Sana S. |
| status_str | publishedVersion |
| title | Immunological Profile of Patients with Rheumatoid Arthritis and Asthma |
| title_full | Immunological Profile of Patients with Rheumatoid Arthritis and Asthma |
| title_fullStr | Immunological Profile of Patients with Rheumatoid Arthritis and Asthma |
| title_full_unstemmed | Immunological Profile of Patients with Rheumatoid Arthritis and Asthma |
| title_short | Immunological Profile of Patients with Rheumatoid Arthritis and Asthma |
| title_sort | Immunological Profile of Patients with Rheumatoid Arthritis and Asthma |
| url | http://hdl.handle.net/11675/14435 https: |