Structure-neurotoxicity trends of analogues of 1-methyl-4-phenylpyridinium (MPP+), the cytotoxic metabolite of the dopaminergic neurotoxin MPTP
The dopaminergic neurotoxicity of 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) derives from its metabolism to 1-methyl-4-phenylpyridinium cation (MPP+), which is then selectively accumulated in dopaminergic neurons. In an effort to assess the structural requirements governing MPP+ cytotoxi...
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| Other Authors: | , , , , |
| Format: | article |
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1990
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| Online Access: | http://hdl.handle.net/10725/10431 https://doi.org/10.1016/0024-3205(90)90018-M http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://www.sciencedirect.com/science/article/pii/002432059090018M |
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