Effects of Sildenafil in Nω-Nitro-l-Arginine Methyl Ester–Induced Intrauterine Growth Restriction in a Rat Model
Objective To assess the effect of sildenafil citrate in a rat model of Nω-nitro-l-arginine methyl ester (L-NAME)-induced intrauterine growth restriction (IUGR). Study Design An in vivo experimental study was conducted where 40 pregnant Sprague-Dawley rats were randomly assigned to receive either: (1...
محفوظ في:
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| مؤلفون آخرون: | , , , |
| التنسيق: | article |
| منشور في: |
2012
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| الوصول للمادة أونلاين: | http://hdl.handle.net/10725/3978 http://dx.doi.org/10.1055/s-0032-1304823 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://www.thieme-connect.com/products/ejournals/html/10.1055/s-0032-1304823 |
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| _version_ | 1864513462767452160 |
|---|---|
| author | Abi Nader, Khalil |
| author2 | Nassar, Anwar H. Masrouha, Karim Z. Itani, Hana Usta, Ihab M. |
| author2_role | author author author author |
| author_facet | Abi Nader, Khalil Nassar, Anwar H. Masrouha, Karim Z. Itani, Hana Usta, Ihab M. |
| author_role | author |
| dc.creator.none.fl_str_mv | Abi Nader, Khalil Nassar, Anwar H. Masrouha, Karim Z. Itani, Hana Usta, Ihab M. |
| dc.date.none.fl_str_mv | 2012 2016-06-08T09:30:11Z 2016-06-08T09:30:11Z 2016-06-08 |
| dc.identifier.none.fl_str_mv | 0735-1631 http://hdl.handle.net/10725/3978 http://dx.doi.org/10.1055/s-0032-1304823 Nassar, A. H., Masrouha, K. Z., Itani, H., Nader, K. A., & Usta, I. M. (2012). Effects of sildenafil in Nω-nitro-L-arginine methyl ester-induced intrauterine growth restriction in a rat model. American journal of perinatology, 29(6), 429. http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://www.thieme-connect.com/products/ejournals/html/10.1055/s-0032-1304823 |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | American journal of perinatology |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | Effects of Sildenafil in Nω-Nitro-l-Arginine Methyl Ester–Induced Intrauterine Growth Restriction in a Rat Model |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Objective To assess the effect of sildenafil citrate in a rat model of Nω-nitro-l-arginine methyl ester (L-NAME)-induced intrauterine growth restriction (IUGR). Study Design An in vivo experimental study was conducted where 40 pregnant Sprague-Dawley rats were randomly assigned to receive either: (1) control, (2) L-NAME 50 mg/kg/d by gavage (days 14 to 19), (3) L-NAME and sildenafil 15 mg/kg/d by gavage, or (4) sildenafil (days 14 to 21). On day 21, a hysterotomy was performed and all fetuses (live and dead) were counted, examined, and weighed. The primary outcome measure was the difference in pup birth weight. Results The median number of live pups per dam was 11.5 (range: 1 to 15), 13.5 (2 to 17), 13.5 (7 to 16), and 11.5 (4 to 17) in controls, L-NAME, sildenafil, and combined drug groups, respectively (p = 0.02). Rats treated with L-NAME had a significantly higher number of stillbirths compared with control (p = 0.013) and sildenafil (p = 0.008) groups. L-NAME reduced pup birth weight compared with controls (4.53 ± 1.49 versus 5.65 ± 1.63 g, p < 0.001); this effect was more pronounced in the L-NAME and sildenafil groups (3.37 ± 1.25 g, p < 0.001). Conclusion Our data indicate that sildenafil citrate does not ameliorate L-NAME-induced IUGR, and in the doses utilized in this study might even have a synergistic negative effect on pup birth weight. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_024e6959e9aff691e03adf80e3c97bcb |
| identifier_str_mv | 0735-1631 Nassar, A. H., Masrouha, K. Z., Itani, H., Nader, K. A., & Usta, I. M. (2012). Effects of sildenafil in Nω-nitro-L-arginine methyl ester-induced intrauterine growth restriction in a rat model. American journal of perinatology, 29(6), 429. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/3978 |
| publishDate | 2012 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Effects of Sildenafil in Nω-Nitro-l-Arginine Methyl Ester–Induced Intrauterine Growth Restriction in a Rat ModelAbi Nader, KhalilNassar, Anwar H.Masrouha, Karim Z.Itani, HanaUsta, Ihab M.Objective To assess the effect of sildenafil citrate in a rat model of Nω-nitro-l-arginine methyl ester (L-NAME)-induced intrauterine growth restriction (IUGR). Study Design An in vivo experimental study was conducted where 40 pregnant Sprague-Dawley rats were randomly assigned to receive either: (1) control, (2) L-NAME 50 mg/kg/d by gavage (days 14 to 19), (3) L-NAME and sildenafil 15 mg/kg/d by gavage, or (4) sildenafil (days 14 to 21). On day 21, a hysterotomy was performed and all fetuses (live and dead) were counted, examined, and weighed. The primary outcome measure was the difference in pup birth weight. Results The median number of live pups per dam was 11.5 (range: 1 to 15), 13.5 (2 to 17), 13.5 (7 to 16), and 11.5 (4 to 17) in controls, L-NAME, sildenafil, and combined drug groups, respectively (p = 0.02). Rats treated with L-NAME had a significantly higher number of stillbirths compared with control (p = 0.013) and sildenafil (p = 0.008) groups. L-NAME reduced pup birth weight compared with controls (4.53 ± 1.49 versus 5.65 ± 1.63 g, p < 0.001); this effect was more pronounced in the L-NAME and sildenafil groups (3.37 ± 1.25 g, p < 0.001). Conclusion Our data indicate that sildenafil citrate does not ameliorate L-NAME-induced IUGR, and in the doses utilized in this study might even have a synergistic negative effect on pup birth weight.PublishedN/A2016-06-08T09:30:11Z2016-06-08T09:30:11Z20122016-06-08Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article0735-1631http://hdl.handle.net/10725/3978http://dx.doi.org/10.1055/s-0032-1304823Nassar, A. H., Masrouha, K. Z., Itani, H., Nader, K. A., & Usta, I. M. (2012). Effects of sildenafil in Nω-nitro-L-arginine methyl ester-induced intrauterine growth restriction in a rat model. American journal of perinatology, 29(6), 429.http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.phphttps://www.thieme-connect.com/products/ejournals/html/10.1055/s-0032-1304823enAmerican journal of perinatologyinfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/39782021-03-19T10:03:20Z |
| spellingShingle | Effects of Sildenafil in Nω-Nitro-l-Arginine Methyl Ester–Induced Intrauterine Growth Restriction in a Rat Model Abi Nader, Khalil |
| status_str | publishedVersion |
| title | Effects of Sildenafil in Nω-Nitro-l-Arginine Methyl Ester–Induced Intrauterine Growth Restriction in a Rat Model |
| title_full | Effects of Sildenafil in Nω-Nitro-l-Arginine Methyl Ester–Induced Intrauterine Growth Restriction in a Rat Model |
| title_fullStr | Effects of Sildenafil in Nω-Nitro-l-Arginine Methyl Ester–Induced Intrauterine Growth Restriction in a Rat Model |
| title_full_unstemmed | Effects of Sildenafil in Nω-Nitro-l-Arginine Methyl Ester–Induced Intrauterine Growth Restriction in a Rat Model |
| title_short | Effects of Sildenafil in Nω-Nitro-l-Arginine Methyl Ester–Induced Intrauterine Growth Restriction in a Rat Model |
| title_sort | Effects of Sildenafil in Nω-Nitro-l-Arginine Methyl Ester–Induced Intrauterine Growth Restriction in a Rat Model |
| url | http://hdl.handle.net/10725/3978 http://dx.doi.org/10.1055/s-0032-1304823 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://www.thieme-connect.com/products/ejournals/html/10.1055/s-0032-1304823 |