Comparison of Pulmonary Complications after Nonmyeloablative and Conventional Allogeneic Hematopoietic Cell Transplant
Nonmyeloablative conditioning before allogeneic hematopoietic cell transplant (HCT) is an alternative to conventional conditioning in older patients and those with comorbidities. It is not known whether the decreased tissue injury associated with nonmyeloablative conditioning lowers the risk of pulm...
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2012
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| Online Access: | http://hdl.handle.net/10725/10480 https://doi.org/10.1016/j.bbmt.2012.06.013 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://www.sciencedirect.com/science/article/pii/S1083879112002601 |
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| _version_ | 1864513486635139072 |
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| author | Diab, Khalil J. |
| author2 | Yu, Zhangsheng Wood, Karen L. Shmalo, James A. Sheski, Francis D. Farber, Mark O. Wilkes, David S. Nelson, Robert P. |
| author2_role | author author author author author author author |
| author_facet | Diab, Khalil J. Yu, Zhangsheng Wood, Karen L. Shmalo, James A. Sheski, Francis D. Farber, Mark O. Wilkes, David S. Nelson, Robert P. |
| author_role | author |
| dc.creator.none.fl_str_mv | Diab, Khalil J. Yu, Zhangsheng Wood, Karen L. Shmalo, James A. Sheski, Francis D. Farber, Mark O. Wilkes, David S. Nelson, Robert P. |
| dc.date.none.fl_str_mv | 2012 2019-04-18T12:54:47Z 2019-04-18T12:54:47Z 2019-04-18 |
| dc.identifier.none.fl_str_mv | 1083-8791 http://hdl.handle.net/10725/10480 https://doi.org/10.1016/j.bbmt.2012.06.013 Diab, K. J., Yu, Z., Wood, K. L., Shmalo, J. A., Sheski, F. D., Farber, M. O., ... & Nelson Jr, R. P. (2012). Comparison of pulmonary complications after nonmyeloablative and conventional allogeneic hematopoietic cell transplant. Biology of Blood and Marrow Transplantation, 18(12), 1827-1834. http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://www.sciencedirect.com/science/article/pii/S1083879112002601 |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | Biology of Blood and Marrow Transplantation |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | Comparison of Pulmonary Complications after Nonmyeloablative and Conventional Allogeneic Hematopoietic Cell Transplant |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Nonmyeloablative conditioning before allogeneic hematopoietic cell transplant (HCT) is an alternative to conventional conditioning in older patients and those with comorbidities. It is not known whether the decreased tissue injury associated with nonmyeloablative conditioning lowers the risk of pulmonary complications. The medical records of patients who underwent transplantation were reviewed and all pulmonary complications documented. Sixty-two consecutive patients with hematologic malignancies who underwent minimally intensive HCT (subjects) were compared to 48 consecutive patients who received conventional myeloablative allogeneic peripheral blood HCT (controls) over the same period at Indiana University Hospital. Pulmonary complications were categorized according to the type of complication and the time of onset after transplantation. Median follow-up times were similar between groups (P = .70). The study population (minimal intensity recipients) was older (P < .01), and the incidence of chronic graft-versus-host disease (cGVHD) was higher in subjects than controls (P = .02). Sixty-nine percent of subjects and 73% of controls developed pulmonary complications (P = .70). There was a trend in the minimally conditioned patients towards a lower incidence of pulmonary complications in older patients in the early posttransplantation period and a higher incidence of infectious pneumonias and bronchiolitis obliterans syndrome at later time points. The frequency of pulmonary complications seems to be similar after minimally intensive or myeloablative conditioning and allotransplantation. There was no difference in overall mortality or pulmonary-related mortality between the 2 groups. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_04c400a47a674a13168de842e99538e3 |
| identifier_str_mv | 1083-8791 Diab, K. J., Yu, Z., Wood, K. L., Shmalo, J. A., Sheski, F. D., Farber, M. O., ... & Nelson Jr, R. P. (2012). Comparison of pulmonary complications after nonmyeloablative and conventional allogeneic hematopoietic cell transplant. Biology of Blood and Marrow Transplantation, 18(12), 1827-1834. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/10480 |
| publishDate | 2012 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Comparison of Pulmonary Complications after Nonmyeloablative and Conventional Allogeneic Hematopoietic Cell TransplantDiab, Khalil J.Yu, ZhangshengWood, Karen L.Shmalo, James A.Sheski, Francis D.Farber, Mark O.Wilkes, David S.Nelson, Robert P.Nonmyeloablative conditioning before allogeneic hematopoietic cell transplant (HCT) is an alternative to conventional conditioning in older patients and those with comorbidities. It is not known whether the decreased tissue injury associated with nonmyeloablative conditioning lowers the risk of pulmonary complications. The medical records of patients who underwent transplantation were reviewed and all pulmonary complications documented. Sixty-two consecutive patients with hematologic malignancies who underwent minimally intensive HCT (subjects) were compared to 48 consecutive patients who received conventional myeloablative allogeneic peripheral blood HCT (controls) over the same period at Indiana University Hospital. Pulmonary complications were categorized according to the type of complication and the time of onset after transplantation. Median follow-up times were similar between groups (P = .70). The study population (minimal intensity recipients) was older (P < .01), and the incidence of chronic graft-versus-host disease (cGVHD) was higher in subjects than controls (P = .02). Sixty-nine percent of subjects and 73% of controls developed pulmonary complications (P = .70). There was a trend in the minimally conditioned patients towards a lower incidence of pulmonary complications in older patients in the early posttransplantation period and a higher incidence of infectious pneumonias and bronchiolitis obliterans syndrome at later time points. The frequency of pulmonary complications seems to be similar after minimally intensive or myeloablative conditioning and allotransplantation. There was no difference in overall mortality or pulmonary-related mortality between the 2 groups.PublishedN/A2019-04-18T12:54:47Z2019-04-18T12:54:47Z20122019-04-18Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1083-8791http://hdl.handle.net/10725/10480https://doi.org/10.1016/j.bbmt.2012.06.013Diab, K. J., Yu, Z., Wood, K. L., Shmalo, J. A., Sheski, F. D., Farber, M. O., ... & Nelson Jr, R. P. (2012). Comparison of pulmonary complications after nonmyeloablative and conventional allogeneic hematopoietic cell transplant. Biology of Blood and Marrow Transplantation, 18(12), 1827-1834.http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.phphttps://www.sciencedirect.com/science/article/pii/S1083879112002601enBiology of Blood and Marrow Transplantationinfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/104802021-03-19T10:47:34Z |
| spellingShingle | Comparison of Pulmonary Complications after Nonmyeloablative and Conventional Allogeneic Hematopoietic Cell Transplant Diab, Khalil J. |
| status_str | publishedVersion |
| title | Comparison of Pulmonary Complications after Nonmyeloablative and Conventional Allogeneic Hematopoietic Cell Transplant |
| title_full | Comparison of Pulmonary Complications after Nonmyeloablative and Conventional Allogeneic Hematopoietic Cell Transplant |
| title_fullStr | Comparison of Pulmonary Complications after Nonmyeloablative and Conventional Allogeneic Hematopoietic Cell Transplant |
| title_full_unstemmed | Comparison of Pulmonary Complications after Nonmyeloablative and Conventional Allogeneic Hematopoietic Cell Transplant |
| title_short | Comparison of Pulmonary Complications after Nonmyeloablative and Conventional Allogeneic Hematopoietic Cell Transplant |
| title_sort | Comparison of Pulmonary Complications after Nonmyeloablative and Conventional Allogeneic Hematopoietic Cell Transplant |
| url | http://hdl.handle.net/10725/10480 https://doi.org/10.1016/j.bbmt.2012.06.013 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://www.sciencedirect.com/science/article/pii/S1083879112002601 |