Micro-fractional ablative skin resurfacing with two novel erbium laser systems
Background and Objectives Fractional ablation offers the potential benefits of full-surface ablative skin resurfacing while minimizing adverse effects. The purpose of this study was to evaluate the safety, damage profile, and efficacy of erbium fractional lasers. Materials and Methods Histology from...
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2017
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| Online Access: | http://hdl.handle.net/10725/6537 http://dx.doi.org/10.1002/lsm.20601 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://onlinelibrary.wiley.com/doi/10.1002/lsm.20601/full |
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| _version_ | 1864513480193736704 |
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| author | Tannous, Zeina S. |
| author2 | Khatri, Khalil A. Dierickx, Christine C. Childs, James J. Tabatadze, David |
| author2_role | author author author author |
| author_facet | Tannous, Zeina S. Khatri, Khalil A. Dierickx, Christine C. Childs, James J. Tabatadze, David |
| author_role | author |
| dc.creator.none.fl_str_mv | Tannous, Zeina S. Khatri, Khalil A. Dierickx, Christine C. Childs, James J. Tabatadze, David |
| dc.date.none.fl_str_mv | 2017-11-08T08:41:04Z 2017-11-08T08:41:04Z 2017-11-08 |
| dc.identifier.none.fl_str_mv | 1096-9101 http://hdl.handle.net/10725/6537 http://dx.doi.org/10.1002/lsm.20601 Dierickx, C. C., Khatri, K. A., Tannous, Z. S., Childs, J. J., Cohen, R. H., Erofeev, A., ... & Altshuler, G. B. (2008). Micro‐fractional ablative skin resurfacing with two novel erbium laser systems. Lasers in surgery and medicine, 40(2), 113-123. http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://onlinelibrary.wiley.com/doi/10.1002/lsm.20601/full |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | Lasers in Surgery and Medicine |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | Micro-fractional ablative skin resurfacing with two novel erbium laser systems |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Background and Objectives Fractional ablation offers the potential benefits of full-surface ablative skin resurfacing while minimizing adverse effects. The purpose of this study was to evaluate the safety, damage profile, and efficacy of erbium fractional lasers. Materials and Methods Histology from animal and human skin as well as clinical evaluations were conducted with erbium YAG (2,940 nm) and erbium YSGG (2,790 nm) fractional lasers varying pulse width, microbeam (µb) energy, number of passes, and stacking of pulses. Results Single-pulse treatment parameters from 1 to 12 mJ per 50–70 µm diameter microbeam and 0.25–5 milliseconds pulse widths produced microcolumns of ablation with border coagulation of up to 100 µm width and 450 µm depth. Stacking of pulses generated deeper microcolumns. Clinical observations and in vivo histology demonstrate rapid re-epithelization and limited adverse side effects. Facial treatments were performed in the periorbital and perioral areas using 1–8 passes of single and stacked pulses. Treatments were well-tolerated and subjects could resume their normal routine in 4 days. A statistically significant reduction in wrinkle scores at 3 months was observed for both periorbital and perioral wrinkles using blinded grading. For periorbital treatments of four passes or more, over 90% had ≥1 score wrinkle reduction (0–9 scale) and 42% had ≥2. For perioral wrinkles, over 50% had substantial improvements (≥2). Conclusion The clinical observations and histology findings demonstrate that micro-fractional ablative treatment with 2,790 and 2,940 nm erbium lasers resulted in safe and effective wrinkle reduction with minimal patient downtime. The depth and width of the ablated microcolumns and varying extent of surrounding coagulation can be controlled and used to design new treatment procedures targeted for specific indications and areas such as moderate to severe rhytides and photodamaged skin. Lesers Surg. Med. 40:113–123, 2008. © 2008 Wiley-Liss, Inc. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_062bc628c1cfcf0a3a1c84418feb78e5 |
| identifier_str_mv | 1096-9101 Dierickx, C. C., Khatri, K. A., Tannous, Z. S., Childs, J. J., Cohen, R. H., Erofeev, A., ... & Altshuler, G. B. (2008). Micro‐fractional ablative skin resurfacing with two novel erbium laser systems. Lasers in surgery and medicine, 40(2), 113-123. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/6537 |
| publishDate | 2017 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Micro-fractional ablative skin resurfacing with two novel erbium laser systemsTannous, Zeina S.Khatri, Khalil A.Dierickx, Christine C.Childs, James J.Tabatadze, DavidBackground and Objectives Fractional ablation offers the potential benefits of full-surface ablative skin resurfacing while minimizing adverse effects. The purpose of this study was to evaluate the safety, damage profile, and efficacy of erbium fractional lasers. Materials and Methods Histology from animal and human skin as well as clinical evaluations were conducted with erbium YAG (2,940 nm) and erbium YSGG (2,790 nm) fractional lasers varying pulse width, microbeam (µb) energy, number of passes, and stacking of pulses. Results Single-pulse treatment parameters from 1 to 12 mJ per 50–70 µm diameter microbeam and 0.25–5 milliseconds pulse widths produced microcolumns of ablation with border coagulation of up to 100 µm width and 450 µm depth. Stacking of pulses generated deeper microcolumns. Clinical observations and in vivo histology demonstrate rapid re-epithelization and limited adverse side effects. Facial treatments were performed in the periorbital and perioral areas using 1–8 passes of single and stacked pulses. Treatments were well-tolerated and subjects could resume their normal routine in 4 days. A statistically significant reduction in wrinkle scores at 3 months was observed for both periorbital and perioral wrinkles using blinded grading. For periorbital treatments of four passes or more, over 90% had ≥1 score wrinkle reduction (0–9 scale) and 42% had ≥2. For perioral wrinkles, over 50% had substantial improvements (≥2). Conclusion The clinical observations and histology findings demonstrate that micro-fractional ablative treatment with 2,790 and 2,940 nm erbium lasers resulted in safe and effective wrinkle reduction with minimal patient downtime. The depth and width of the ablated microcolumns and varying extent of surrounding coagulation can be controlled and used to design new treatment procedures targeted for specific indications and areas such as moderate to severe rhytides and photodamaged skin. Lesers Surg. Med. 40:113–123, 2008. © 2008 Wiley-Liss, Inc.PublishedN/A2017-11-08T08:41:04Z2017-11-08T08:41:04Z2017-11-08Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1096-9101http://hdl.handle.net/10725/6537http://dx.doi.org/10.1002/lsm.20601Dierickx, C. C., Khatri, K. A., Tannous, Z. S., Childs, J. J., Cohen, R. H., Erofeev, A., ... & Altshuler, G. B. (2008). Micro‐fractional ablative skin resurfacing with two novel erbium laser systems. Lasers in surgery and medicine, 40(2), 113-123.http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.phphttp://onlinelibrary.wiley.com/doi/10.1002/lsm.20601/fullenLasers in Surgery and Medicineinfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/65372021-03-19T10:03:27Z |
| spellingShingle | Micro-fractional ablative skin resurfacing with two novel erbium laser systems Tannous, Zeina S. |
| status_str | publishedVersion |
| title | Micro-fractional ablative skin resurfacing with two novel erbium laser systems |
| title_full | Micro-fractional ablative skin resurfacing with two novel erbium laser systems |
| title_fullStr | Micro-fractional ablative skin resurfacing with two novel erbium laser systems |
| title_full_unstemmed | Micro-fractional ablative skin resurfacing with two novel erbium laser systems |
| title_short | Micro-fractional ablative skin resurfacing with two novel erbium laser systems |
| title_sort | Micro-fractional ablative skin resurfacing with two novel erbium laser systems |
| url | http://hdl.handle.net/10725/6537 http://dx.doi.org/10.1002/lsm.20601 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://onlinelibrary.wiley.com/doi/10.1002/lsm.20601/full |