Pathologic Response to Preoperative Chemotherapy
Purpose The primary goal of this study was to evaluate whether pathologic response to chemotherapy predicts patient survival after preoperative chemotherapy and resection of colorectal liver metastases (CLM). The secondary goal of the study was to identify the clinical predictors of pathologic respo...
محفوظ في:
| المؤلف الرئيسي: | |
|---|---|
| مؤلفون آخرون: | , , , , , , , , , , , , , , , |
| التنسيق: | article |
| منشور في: |
2008
|
| الوصول للمادة أونلاين: | http://hdl.handle.net/10725/2584 http://dx.doi.org/10.1200/JCO.2008.17.5299 http://jco.ascopubs.org/content/26/33/5344.short |
| الوسوم: |
إضافة وسم
لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!
|
| _version_ | 1864513458663325696 |
|---|---|
| author | Blazer III, Dan |
| author2 | Kishi, Yoji Maru, Dipen Shin Chun, Yun Overman, Micheal Fogelman, David Eng, Cathy Chang, David Wang, Huamin Zorzi, Daria Ribero, Dario Ellis, Lee Glover, Katrina Wolff, Robert Curley, Steven Abdalla, Eddie Vauthey, Nicolas |
| author2_role | author author author author author author author author author author author author author author author author |
| author_facet | Blazer III, Dan Kishi, Yoji Maru, Dipen Shin Chun, Yun Overman, Micheal Fogelman, David Eng, Cathy Chang, David Wang, Huamin Zorzi, Daria Ribero, Dario Ellis, Lee Glover, Katrina Wolff, Robert Curley, Steven Abdalla, Eddie Vauthey, Nicolas |
| author_role | author |
| dc.creator.none.fl_str_mv | Blazer III, Dan Kishi, Yoji Maru, Dipen Shin Chun, Yun Overman, Micheal Fogelman, David Eng, Cathy Chang, David Wang, Huamin Zorzi, Daria Ribero, Dario Ellis, Lee Glover, Katrina Wolff, Robert Curley, Steven Abdalla, Eddie Vauthey, Nicolas |
| dc.date.none.fl_str_mv | 2008 2015-11-16T12:43:44Z 2015-11-16T12:43:44Z 2015-11-16 |
| dc.identifier.none.fl_str_mv | 0732-183X http://hdl.handle.net/10725/2584 http://dx.doi.org/10.1200/JCO.2008.17.5299 Blazer, D. G., Kishi, Y., Maru, D. M., Kopetz, S., Chun, Y. S., Overman, M. J., ... & Vauthey, J. N. (2008). Pathologic response to preoperative chemotherapy: a new outcome end point after resection of hepatic colorectal metastases. Journal of Clinical Oncology, 26(33), 5344-5351. http://jco.ascopubs.org/content/26/33/5344.short |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | Journal of Clinical Oncology |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | Pathologic Response to Preoperative Chemotherapy A New Outcome End Point After Resection of Hepatic Colorectal Metastases |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Purpose The primary goal of this study was to evaluate whether pathologic response to chemotherapy predicts patient survival after preoperative chemotherapy and resection of colorectal liver metastases (CLM). The secondary goal of the study was to identify the clinical predictors of pathologic response. Patients and Methods A retrospective review was performed of 305 patients who underwent preoperative irinotecan- or oxaliplatin-based chemotherapy, followed by resection of CLM. Pathologic response was systematically evaluated and reported as the mean of the percentage of cancer cells remaining within each tumor. Univariate and multivariate analyses were performed to identify the predictors of pathologic response and survival. Results Cumulative 5-year overall survival rates by pathologic response status were as follows: 75% complete response (no residual cancer cells), 56% major response (1% to 49% residual cancer cells), and 33% minor response (≥ 50% residual cancer cells; complete v major response, P = .037; major v minor response, P = .028). Multivariate analysis revealed that only surgical margin status (P = .050; hazard ratio [HR], 1.77) and pathologic response (major response: P = .034; HR, 4.80; minor response: P = .007; HR, 6.93) were independent predictors of survival. Multivariate analysis of the predictors of pathologic response revealed that carcinoembryonic antigen level ≤ 5 ng/mL, tumor size ≤ 3 cm, and chemotherapy with fluoropyrimidine plus oxaliplatin and bevacizumab were independent predictors of pathologic response. Conclusion Pathologic response predicts survival after preoperative chemotherapy and resection of CLM. Degree of pathologic response represents a new outcome end point for prognosis after resection of CLM. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_0755cb415f729b2b578bb375acce1fd0 |
| identifier_str_mv | 0732-183X Blazer, D. G., Kishi, Y., Maru, D. M., Kopetz, S., Chun, Y. S., Overman, M. J., ... & Vauthey, J. N. (2008). Pathologic response to preoperative chemotherapy: a new outcome end point after resection of hepatic colorectal metastases. Journal of Clinical Oncology, 26(33), 5344-5351. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/2584 |
| publishDate | 2008 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Pathologic Response to Preoperative ChemotherapyA New Outcome End Point After Resection of Hepatic Colorectal MetastasesBlazer III, DanKishi, YojiMaru, DipenShin Chun, YunOverman, MichealFogelman, DavidEng, CathyChang, DavidWang, HuaminZorzi, DariaRibero, DarioEllis, LeeGlover, KatrinaWolff, RobertCurley, StevenAbdalla, EddieVauthey, NicolasPurpose The primary goal of this study was to evaluate whether pathologic response to chemotherapy predicts patient survival after preoperative chemotherapy and resection of colorectal liver metastases (CLM). The secondary goal of the study was to identify the clinical predictors of pathologic response. Patients and Methods A retrospective review was performed of 305 patients who underwent preoperative irinotecan- or oxaliplatin-based chemotherapy, followed by resection of CLM. Pathologic response was systematically evaluated and reported as the mean of the percentage of cancer cells remaining within each tumor. Univariate and multivariate analyses were performed to identify the predictors of pathologic response and survival. Results Cumulative 5-year overall survival rates by pathologic response status were as follows: 75% complete response (no residual cancer cells), 56% major response (1% to 49% residual cancer cells), and 33% minor response (≥ 50% residual cancer cells; complete v major response, P = .037; major v minor response, P = .028). Multivariate analysis revealed that only surgical margin status (P = .050; hazard ratio [HR], 1.77) and pathologic response (major response: P = .034; HR, 4.80; minor response: P = .007; HR, 6.93) were independent predictors of survival. Multivariate analysis of the predictors of pathologic response revealed that carcinoembryonic antigen level ≤ 5 ng/mL, tumor size ≤ 3 cm, and chemotherapy with fluoropyrimidine plus oxaliplatin and bevacizumab were independent predictors of pathologic response. Conclusion Pathologic response predicts survival after preoperative chemotherapy and resection of CLM. Degree of pathologic response represents a new outcome end point for prognosis after resection of CLM.PublishedN/A2015-11-16T12:43:44Z2015-11-16T12:43:44Z20082015-11-16Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article0732-183Xhttp://hdl.handle.net/10725/2584http://dx.doi.org/10.1200/JCO.2008.17.5299Blazer, D. G., Kishi, Y., Maru, D. M., Kopetz, S., Chun, Y. S., Overman, M. J., ... & Vauthey, J. N. (2008). Pathologic response to preoperative chemotherapy: a new outcome end point after resection of hepatic colorectal metastases. Journal of Clinical Oncology, 26(33), 5344-5351.http://jco.ascopubs.org/content/26/33/5344.shortenJournal of Clinical Oncologyinfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/25842016-08-26T06:41:36Z |
| spellingShingle | Pathologic Response to Preoperative Chemotherapy Blazer III, Dan |
| status_str | publishedVersion |
| title | Pathologic Response to Preoperative Chemotherapy |
| title_full | Pathologic Response to Preoperative Chemotherapy |
| title_fullStr | Pathologic Response to Preoperative Chemotherapy |
| title_full_unstemmed | Pathologic Response to Preoperative Chemotherapy |
| title_short | Pathologic Response to Preoperative Chemotherapy |
| title_sort | Pathologic Response to Preoperative Chemotherapy |
| url | http://hdl.handle.net/10725/2584 http://dx.doi.org/10.1200/JCO.2008.17.5299 http://jco.ascopubs.org/content/26/33/5344.short |