Consolidative Radiation Therapy for Stage III Hodgkin Lymphoma in Patients Who Achieve Complete Response After ABVD Chemotherapy
Objectives: To examine the role of consolidation radiation therapy (RT) for patients with stage III Hodgkin lymphoma. Methods: We retrospectively reviewed 118 patients with stage III Hodgkin lymphoma who were diagnosed and treated at the University of Texas M.D. Anderson Cancer Center from 1993 thro...
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| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , , , , , , , |
| التنسيق: | article |
| منشور في: |
2011
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| الوصول للمادة أونلاين: | http://hdl.handle.net/10725/2310 http://dx.doi.org/10.1097/COC.0b013e3181f477a8 http://journals.lww.com/amjclinicaloncology/Abstract/2011/10000/Consolidative_Radiation_Therapy_for_Stage_III.11.aspx |
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| _version_ | 1864513457903108096 |
|---|---|
| author | Zreik, Tony |
| author2 | Phan, Jack Mazloom, Ali Abboud, Mirna Salehpour, Mohamad Reed, Valerie Shihadeh, Ferial Fisher, Christine Wogan, Christine Dabaja, Bouthaina |
| author2_role | author author author author author author author author author |
| author_facet | Zreik, Tony Phan, Jack Mazloom, Ali Abboud, Mirna Salehpour, Mohamad Reed, Valerie Shihadeh, Ferial Fisher, Christine Wogan, Christine Dabaja, Bouthaina |
| author_role | author |
| dc.creator.none.fl_str_mv | Zreik, Tony Phan, Jack Mazloom, Ali Abboud, Mirna Salehpour, Mohamad Reed, Valerie Shihadeh, Ferial Fisher, Christine Wogan, Christine Dabaja, Bouthaina |
| dc.date.none.fl_str_mv | 2011 2015-10-22T12:18:24Z 2015-10-22T12:18:24Z 2015-10-22 |
| dc.identifier.none.fl_str_mv | 0277-3732 http://hdl.handle.net/10725/2310 http://dx.doi.org/10.1097/COC.0b013e3181f477a8 Phan, J., Mazloom, A., Abboud, M., Salehpour, M., Reed, V., Zreik, T., ... & Dabaja, B. (2011). Consolidative Radiation Therapy for Stage III Hodgkin Lymphoma in Patients Who Achieve Complete Response After ABVD Chemotherapy. American journal of clinical oncology, 34(5), 499-505. http://journals.lww.com/amjclinicaloncology/Abstract/2011/10000/Consolidative_Radiation_Therapy_for_Stage_III.11.aspx |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | American journal of clinical oncology |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | Consolidative Radiation Therapy for Stage III Hodgkin Lymphoma in Patients Who Achieve Complete Response After ABVD Chemotherapy |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Objectives: To examine the role of consolidation radiation therapy (RT) for patients with stage III Hodgkin lymphoma. Methods: We retrospectively reviewed 118 patients with stage III Hodgkin lymphoma who were diagnosed and treated at the University of Texas M.D. Anderson Cancer Center from 1993 through 2006. We evaluated the influence of site and size of initial involvement and use of consolidative RT on survival and patterns of failure after complete response (CR) to ABVD chemotherapy (doxorubicin, bleomycin, vinblastine, and dacarbazine). Results: After chemotherapy, 104 patients (88%) achieved CR; median follow-up time was 68 months (range, 8 to 190). Seventy-one patients (68%) received ≥6 cycles of ABVD, and 40 patients (38.5%) received consolidative RT. Comparing patients who received RT with those who did not, the 5-year, 10-year, and 15-year overall survival (OS) rates were 98%, 80%, and 80% versus 91%, 72%, and 29%, respectively (P=0.08). Disease-free survival (DFS) rates were 94%, 81%, 65% versus 78%, 45%, and 15%, respectively (P=0.04). On multivariate analysis, the presence of initial mediastinal involvement (P=0.001) and bulky head and neck disease (P=0.001) was associated with worse DFS; mediastinal RT was associated with improved DFS (P=0.003) and OS (P=0.029). Use of ≥6 cycles of ABVD was associated with improved OS (P=0.001). The pattern of failure analysis showed that most failures (23 of 28) occurred above the diaphragm. Conclusions: Consolidative RT after CR may benefit patients with initial disease above the diaphragm, whereas below-the-diaphragm disease seems to be well managed by chemotherapy alone. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_07a93ae24701e690a8d0604b282523af |
| identifier_str_mv | 0277-3732 Phan, J., Mazloom, A., Abboud, M., Salehpour, M., Reed, V., Zreik, T., ... & Dabaja, B. (2011). Consolidative Radiation Therapy for Stage III Hodgkin Lymphoma in Patients Who Achieve Complete Response After ABVD Chemotherapy. American journal of clinical oncology, 34(5), 499-505. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/2310 |
| publishDate | 2011 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Consolidative Radiation Therapy for Stage III Hodgkin Lymphoma in Patients Who Achieve Complete Response After ABVD ChemotherapyZreik, TonyPhan, JackMazloom, AliAbboud, MirnaSalehpour, MohamadReed, ValerieShihadeh, FerialFisher, ChristineWogan, ChristineDabaja, BouthainaObjectives: To examine the role of consolidation radiation therapy (RT) for patients with stage III Hodgkin lymphoma. Methods: We retrospectively reviewed 118 patients with stage III Hodgkin lymphoma who were diagnosed and treated at the University of Texas M.D. Anderson Cancer Center from 1993 through 2006. We evaluated the influence of site and size of initial involvement and use of consolidative RT on survival and patterns of failure after complete response (CR) to ABVD chemotherapy (doxorubicin, bleomycin, vinblastine, and dacarbazine). Results: After chemotherapy, 104 patients (88%) achieved CR; median follow-up time was 68 months (range, 8 to 190). Seventy-one patients (68%) received ≥6 cycles of ABVD, and 40 patients (38.5%) received consolidative RT. Comparing patients who received RT with those who did not, the 5-year, 10-year, and 15-year overall survival (OS) rates were 98%, 80%, and 80% versus 91%, 72%, and 29%, respectively (P=0.08). Disease-free survival (DFS) rates were 94%, 81%, 65% versus 78%, 45%, and 15%, respectively (P=0.04). On multivariate analysis, the presence of initial mediastinal involvement (P=0.001) and bulky head and neck disease (P=0.001) was associated with worse DFS; mediastinal RT was associated with improved DFS (P=0.003) and OS (P=0.029). Use of ≥6 cycles of ABVD was associated with improved OS (P=0.001). The pattern of failure analysis showed that most failures (23 of 28) occurred above the diaphragm. Conclusions: Consolidative RT after CR may benefit patients with initial disease above the diaphragm, whereas below-the-diaphragm disease seems to be well managed by chemotherapy alone.PublishedN/A2015-10-22T12:18:24Z2015-10-22T12:18:24Z20112015-10-22Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article0277-3732http://hdl.handle.net/10725/2310http://dx.doi.org/10.1097/COC.0b013e3181f477a8Phan, J., Mazloom, A., Abboud, M., Salehpour, M., Reed, V., Zreik, T., ... & Dabaja, B. (2011). Consolidative Radiation Therapy for Stage III Hodgkin Lymphoma in Patients Who Achieve Complete Response After ABVD Chemotherapy. American journal of clinical oncology, 34(5), 499-505.http://journals.lww.com/amjclinicaloncology/Abstract/2011/10000/Consolidative_Radiation_Therapy_for_Stage_III.11.aspxenAmerican journal of clinical oncologyinfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/23102016-08-25T09:15:11Z |
| spellingShingle | Consolidative Radiation Therapy for Stage III Hodgkin Lymphoma in Patients Who Achieve Complete Response After ABVD Chemotherapy Zreik, Tony |
| status_str | publishedVersion |
| title | Consolidative Radiation Therapy for Stage III Hodgkin Lymphoma in Patients Who Achieve Complete Response After ABVD Chemotherapy |
| title_full | Consolidative Radiation Therapy for Stage III Hodgkin Lymphoma in Patients Who Achieve Complete Response After ABVD Chemotherapy |
| title_fullStr | Consolidative Radiation Therapy for Stage III Hodgkin Lymphoma in Patients Who Achieve Complete Response After ABVD Chemotherapy |
| title_full_unstemmed | Consolidative Radiation Therapy for Stage III Hodgkin Lymphoma in Patients Who Achieve Complete Response After ABVD Chemotherapy |
| title_short | Consolidative Radiation Therapy for Stage III Hodgkin Lymphoma in Patients Who Achieve Complete Response After ABVD Chemotherapy |
| title_sort | Consolidative Radiation Therapy for Stage III Hodgkin Lymphoma in Patients Who Achieve Complete Response After ABVD Chemotherapy |
| url | http://hdl.handle.net/10725/2310 http://dx.doi.org/10.1097/COC.0b013e3181f477a8 http://journals.lww.com/amjclinicaloncology/Abstract/2011/10000/Consolidative_Radiation_Therapy_for_Stage_III.11.aspx |