The Role of Rho GTPases in VEGF Signaling in Cancer Cells
Vascular endothelial growth factors (VEGFs) consist of five molecules (VEGFA through D as well as placental growth factor) which are crucial for regulating key cellular and tissue functions. The role of VEGF and its intracellular signaling and downstream molecular pathways have been thoroughly studi...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , , , |
| التنسيق: | article |
| منشور في: |
2020
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| الوصول للمادة أونلاين: | http://hdl.handle.net/10725/11876 https://doi.org/10.1155/2020/2097214 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://www.hindawi.com/journals/acp/2020/2097214/ |
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| _version_ | 1864513489622532097 |
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| author | El Baba, Nada |
| author2 | Farran, Mohammad Abi Khalil, Elie Jaafar, Leila Fakhoury, Isabelle El-Sibai, Mirvat |
| author2_role | author author author author author |
| author_facet | El Baba, Nada Farran, Mohammad Abi Khalil, Elie Jaafar, Leila Fakhoury, Isabelle El-Sibai, Mirvat |
| author_role | author |
| dc.creator.none.fl_str_mv | El Baba, Nada Farran, Mohammad Abi Khalil, Elie Jaafar, Leila Fakhoury, Isabelle El-Sibai, Mirvat |
| dc.date.none.fl_str_mv | 2020-05-01T13:11:57Z 2020-05-01T13:11:57Z 2020 2020-05-01 |
| dc.identifier.none.fl_str_mv | 2210-7177 http://hdl.handle.net/10725/11876 https://doi.org/10.1155/2020/2097214 El Baba, N., Farran, M., Khalil, E. A., Jaafar, L., Fakhoury, I., & El-Sibai, M. (2020). The Role of Rho GTPases in VEGF Signaling in Cancer Cells. Analytical Cellular Pathology, 2020. http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://www.hindawi.com/journals/acp/2020/2097214/ |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | Analytical Cellular Pathology |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | The Role of Rho GTPases in VEGF Signaling in Cancer Cells |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Vascular endothelial growth factors (VEGFs) consist of five molecules (VEGFA through D as well as placental growth factor) which are crucial for regulating key cellular and tissue functions. The role of VEGF and its intracellular signaling and downstream molecular pathways have been thoroughly studied. Activation of VEGF signal transduction can be initiated by the molecules’ binding to two classes of transmembrane receptors: (1) the VEGF tyrosine kinase receptors (VEGF receptors 1 through 3) and (2) the neuropilins (NRP1 and 2). The involvement of Rho GTPases in modulating VEGFA signaling in both cancer cells and endothelial cells has also been well established. Additionally, different isoforms of Rho GTPases, namely, RhoA, RhoC, and RhoG, have been shown to regulate VEGF expression as well as blood vessel formation. This review article will explore how Rho GTPases modulate VEGF signaling and the consequences of such interaction on cancer progression. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_0992d2a6f45a0083bb6de73644a62641 |
| identifier_str_mv | 2210-7177 El Baba, N., Farran, M., Khalil, E. A., Jaafar, L., Fakhoury, I., & El-Sibai, M. (2020). The Role of Rho GTPases in VEGF Signaling in Cancer Cells. Analytical Cellular Pathology, 2020. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/11876 |
| publishDate | 2020 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | The Role of Rho GTPases in VEGF Signaling in Cancer CellsEl Baba, NadaFarran, MohammadAbi Khalil, ElieJaafar, LeilaFakhoury, IsabelleEl-Sibai, MirvatVascular endothelial growth factors (VEGFs) consist of five molecules (VEGFA through D as well as placental growth factor) which are crucial for regulating key cellular and tissue functions. The role of VEGF and its intracellular signaling and downstream molecular pathways have been thoroughly studied. Activation of VEGF signal transduction can be initiated by the molecules’ binding to two classes of transmembrane receptors: (1) the VEGF tyrosine kinase receptors (VEGF receptors 1 through 3) and (2) the neuropilins (NRP1 and 2). The involvement of Rho GTPases in modulating VEGFA signaling in both cancer cells and endothelial cells has also been well established. Additionally, different isoforms of Rho GTPases, namely, RhoA, RhoC, and RhoG, have been shown to regulate VEGF expression as well as blood vessel formation. This review article will explore how Rho GTPases modulate VEGF signaling and the consequences of such interaction on cancer progression.PublishedN/A2020-05-01T13:11:57Z2020-05-01T13:11:57Z20202020-05-01Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2210-7177http://hdl.handle.net/10725/11876https://doi.org/10.1155/2020/2097214El Baba, N., Farran, M., Khalil, E. A., Jaafar, L., Fakhoury, I., & El-Sibai, M. (2020). The Role of Rho GTPases in VEGF Signaling in Cancer Cells. Analytical Cellular Pathology, 2020.http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.phphttps://www.hindawi.com/journals/acp/2020/2097214/enAnalytical Cellular Pathologyinfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/118762021-03-19T10:47:40Z |
| spellingShingle | The Role of Rho GTPases in VEGF Signaling in Cancer Cells El Baba, Nada |
| status_str | publishedVersion |
| title | The Role of Rho GTPases in VEGF Signaling in Cancer Cells |
| title_full | The Role of Rho GTPases in VEGF Signaling in Cancer Cells |
| title_fullStr | The Role of Rho GTPases in VEGF Signaling in Cancer Cells |
| title_full_unstemmed | The Role of Rho GTPases in VEGF Signaling in Cancer Cells |
| title_short | The Role of Rho GTPases in VEGF Signaling in Cancer Cells |
| title_sort | The Role of Rho GTPases in VEGF Signaling in Cancer Cells |
| url | http://hdl.handle.net/10725/11876 https://doi.org/10.1155/2020/2097214 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://www.hindawi.com/journals/acp/2020/2097214/ |