Large-scale association analysis identifies new risk loci for coronary artery disease
Coronary artery disease (CAD) is the commonest cause of death. Here, we report an association analysis in 63,746 CAD cases and 130,681 controls identifying 15 loci reaching genome-wide significance, taking the number of susceptibility loci for CAD to 46, and a further 104 independent variants (r2 &l...
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| Format: | article |
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2013
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| Online Access: | http://hdl.handle.net/10725/11140 https://doi.org/10.1038/ng.2480 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://www.nature.com/articles/ng.2480 |
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| _version_ | 1864513488312860672 |
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| author | Deloukas, Panos |
| author2 | Zalloua, Pierre A. |
| author2_role | author |
| author_facet | Deloukas, Panos Zalloua, Pierre A. |
| author_role | author |
| dc.creator.none.fl_str_mv | Deloukas, Panos Zalloua, Pierre A. |
| dc.date.none.fl_str_mv | 2013 2019-07-25T07:38:56Z 2019-07-25T07:38:56Z 2019-07-25 |
| dc.identifier.none.fl_str_mv | 1546-1718 http://hdl.handle.net/10725/11140 https://doi.org/10.1038/ng.2480 Deloukas, P., Kanoni, S., Willenborg, C., Farrall, M., Assimes, T. L., Thompson, J. R., ... & Stirrups, K. (2013). Large-scale association analysis identifies new risk loci for coronary artery disease. Nature genetics, 45(1), 25. http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://www.nature.com/articles/ng.2480 |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | Nature Genetics |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | Large-scale association analysis identifies new risk loci for coronary artery disease |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Coronary artery disease (CAD) is the commonest cause of death. Here, we report an association analysis in 63,746 CAD cases and 130,681 controls identifying 15 loci reaching genome-wide significance, taking the number of susceptibility loci for CAD to 46, and a further 104 independent variants (r2 < 0.2) strongly associated with CAD at a 5% false discovery rate (FDR). Together, these variants explain approximately 10.6% of CAD heritability. Of the 46 genome-wide significant lead SNPs, 12 show a significant association with a lipid trait, and 5 show a significant association with blood pressure, but none is significantly associated with diabetes. Network analysis with 233 candidate genes (loci at 10% FDR) generated 5 interaction networks comprising 85% of these putative genes involved in CAD. The four most significant pathways mapping to these networks are linked to lipid metabolism and inflammation, underscoring the causal role of these activities in the genetic etiology of CAD. Our study provides insights into the genetic basis of CAD and identifies key biological pathways. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_0ac77c656bd1c8a7a3de86a871621039 |
| identifier_str_mv | 1546-1718 Deloukas, P., Kanoni, S., Willenborg, C., Farrall, M., Assimes, T. L., Thompson, J. R., ... & Stirrups, K. (2013). Large-scale association analysis identifies new risk loci for coronary artery disease. Nature genetics, 45(1), 25. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/11140 |
| publishDate | 2013 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Large-scale association analysis identifies new risk loci for coronary artery diseaseDeloukas, PanosZalloua, Pierre A.Coronary artery disease (CAD) is the commonest cause of death. Here, we report an association analysis in 63,746 CAD cases and 130,681 controls identifying 15 loci reaching genome-wide significance, taking the number of susceptibility loci for CAD to 46, and a further 104 independent variants (r2 < 0.2) strongly associated with CAD at a 5% false discovery rate (FDR). Together, these variants explain approximately 10.6% of CAD heritability. Of the 46 genome-wide significant lead SNPs, 12 show a significant association with a lipid trait, and 5 show a significant association with blood pressure, but none is significantly associated with diabetes. Network analysis with 233 candidate genes (loci at 10% FDR) generated 5 interaction networks comprising 85% of these putative genes involved in CAD. The four most significant pathways mapping to these networks are linked to lipid metabolism and inflammation, underscoring the causal role of these activities in the genetic etiology of CAD. Our study provides insights into the genetic basis of CAD and identifies key biological pathways.PublishedN/A2019-07-25T07:38:56Z2019-07-25T07:38:56Z20132019-07-25Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1546-1718http://hdl.handle.net/10725/11140https://doi.org/10.1038/ng.2480Deloukas, P., Kanoni, S., Willenborg, C., Farrall, M., Assimes, T. L., Thompson, J. R., ... & Stirrups, K. (2013). Large-scale association analysis identifies new risk loci for coronary artery disease. Nature genetics, 45(1), 25.http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.phphttps://www.nature.com/articles/ng.2480enNature Geneticsinfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/111402021-03-19T10:47:35Z |
| spellingShingle | Large-scale association analysis identifies new risk loci for coronary artery disease Deloukas, Panos |
| status_str | publishedVersion |
| title | Large-scale association analysis identifies new risk loci for coronary artery disease |
| title_full | Large-scale association analysis identifies new risk loci for coronary artery disease |
| title_fullStr | Large-scale association analysis identifies new risk loci for coronary artery disease |
| title_full_unstemmed | Large-scale association analysis identifies new risk loci for coronary artery disease |
| title_short | Large-scale association analysis identifies new risk loci for coronary artery disease |
| title_sort | Large-scale association analysis identifies new risk loci for coronary artery disease |
| url | http://hdl.handle.net/10725/11140 https://doi.org/10.1038/ng.2480 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://www.nature.com/articles/ng.2480 |