The persistence of hippocampal-based memory requires protein synthesis mediated by the prion-like protein CPEB3
Consolidation of long-term memories depends on de novo protein synthesis. Several translational regulators have been identified, and their contribution to the formation of memory has been assessed in the mouse hippocampus. None of them, however, has been implicated in the persistence of memory. Alth...
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2015
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| Online Access: | http://hdl.handle.net/10725/5193 http://dx.doi.org/10.1016/j.neuron.2015.05.021 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://www.sciencedirect.com/science/article/pii/S0896627315004286 |
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| _version_ | 1864513465368969216 |
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| author | Stephan, Joseph S. |
| author2 | Fioriti, Luana Myers, Cory Huang, Yan-You Li, Xiang Trifilieff, Pierre Colnaghi, Luca Kosmidis, Stylianos Drisaldi, Bettina Pavlopoulos, Elias Kandel, Eric R. |
| author2_role | author author author author author author author author author author |
| author_facet | Stephan, Joseph S. Fioriti, Luana Myers, Cory Huang, Yan-You Li, Xiang Trifilieff, Pierre Colnaghi, Luca Kosmidis, Stylianos Drisaldi, Bettina Pavlopoulos, Elias Kandel, Eric R. |
| author_role | author |
| dc.creator.none.fl_str_mv | Stephan, Joseph S. Fioriti, Luana Myers, Cory Huang, Yan-You Li, Xiang Trifilieff, Pierre Colnaghi, Luca Kosmidis, Stylianos Drisaldi, Bettina Pavlopoulos, Elias Kandel, Eric R. |
| dc.date.none.fl_str_mv | 2015 2017-02-06T13:25:14Z 2017-02-06T13:25:14Z 2017-02-06 |
| dc.identifier.none.fl_str_mv | 0896-6273 http://hdl.handle.net/10725/5193 http://dx.doi.org/10.1016/j.neuron.2015.05.021 Fioriti, L., Myers, C., Huang, Y. Y., Li, X., Stephan, J. S., Trifilieff, P., ... & Kandel, E. R. (2015). The persistence of hippocampal-based memory requires protein synthesis mediated by the prion-like protein CPEB3. Neuron, 86(6), 1433-1448. http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://www.sciencedirect.com/science/article/pii/S0896627315004286 |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | Neuron |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | The persistence of hippocampal-based memory requires protein synthesis mediated by the prion-like protein CPEB3 |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Consolidation of long-term memories depends on de novo protein synthesis. Several translational regulators have been identified, and their contribution to the formation of memory has been assessed in the mouse hippocampus. None of them, however, has been implicated in the persistence of memory. Although persistence is a key feature of long-term memory, how this occurs, despite the rapid turnover of its molecular substrates, is poorly understood. Here we find that both memory storage and its underlying synaptic plasticity are mediated by the increase in level and in the aggregation of the prion-like translational regulator CPEB3 (cytoplasmic polyadenylation element-binding protein). Genetic ablation of CPEB3 impairs the maintenance of both hippocampal long-term potentiation and hippocampus-dependent spatial memory. We propose a model whereby persistence of long-term memory results from the assembly of CPEB3 into aggregates. These aggregates serve as functional prions and regulate local protein synthesis necessary for the maintenance of long-term memory. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_0b246e16aef25239c5494b4e47cca897 |
| identifier_str_mv | 0896-6273 Fioriti, L., Myers, C., Huang, Y. Y., Li, X., Stephan, J. S., Trifilieff, P., ... & Kandel, E. R. (2015). The persistence of hippocampal-based memory requires protein synthesis mediated by the prion-like protein CPEB3. Neuron, 86(6), 1433-1448. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/5193 |
| publishDate | 2015 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | The persistence of hippocampal-based memory requires protein synthesis mediated by the prion-like protein CPEB3Stephan, Joseph S.Fioriti, LuanaMyers, CoryHuang, Yan-YouLi, XiangTrifilieff, PierreColnaghi, LucaKosmidis, StylianosDrisaldi, BettinaPavlopoulos, EliasKandel, Eric R.Consolidation of long-term memories depends on de novo protein synthesis. Several translational regulators have been identified, and their contribution to the formation of memory has been assessed in the mouse hippocampus. None of them, however, has been implicated in the persistence of memory. Although persistence is a key feature of long-term memory, how this occurs, despite the rapid turnover of its molecular substrates, is poorly understood. Here we find that both memory storage and its underlying synaptic plasticity are mediated by the increase in level and in the aggregation of the prion-like translational regulator CPEB3 (cytoplasmic polyadenylation element-binding protein). Genetic ablation of CPEB3 impairs the maintenance of both hippocampal long-term potentiation and hippocampus-dependent spatial memory. We propose a model whereby persistence of long-term memory results from the assembly of CPEB3 into aggregates. These aggregates serve as functional prions and regulate local protein synthesis necessary for the maintenance of long-term memory.PublishedN/A2017-02-06T13:25:14Z2017-02-06T13:25:14Z20152017-02-06Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article0896-6273http://hdl.handle.net/10725/5193http://dx.doi.org/10.1016/j.neuron.2015.05.021Fioriti, L., Myers, C., Huang, Y. Y., Li, X., Stephan, J. S., Trifilieff, P., ... & Kandel, E. R. (2015). The persistence of hippocampal-based memory requires protein synthesis mediated by the prion-like protein CPEB3. Neuron, 86(6), 1433-1448.http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.phphttp://www.sciencedirect.com/science/article/pii/S0896627315004286enNeuroninfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/51932021-03-19T10:00:51Z |
| spellingShingle | The persistence of hippocampal-based memory requires protein synthesis mediated by the prion-like protein CPEB3 Stephan, Joseph S. |
| status_str | publishedVersion |
| title | The persistence of hippocampal-based memory requires protein synthesis mediated by the prion-like protein CPEB3 |
| title_full | The persistence of hippocampal-based memory requires protein synthesis mediated by the prion-like protein CPEB3 |
| title_fullStr | The persistence of hippocampal-based memory requires protein synthesis mediated by the prion-like protein CPEB3 |
| title_full_unstemmed | The persistence of hippocampal-based memory requires protein synthesis mediated by the prion-like protein CPEB3 |
| title_short | The persistence of hippocampal-based memory requires protein synthesis mediated by the prion-like protein CPEB3 |
| title_sort | The persistence of hippocampal-based memory requires protein synthesis mediated by the prion-like protein CPEB3 |
| url | http://hdl.handle.net/10725/5193 http://dx.doi.org/10.1016/j.neuron.2015.05.021 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://www.sciencedirect.com/science/article/pii/S0896627315004286 |