Cardiovascular and renal outcome in recipients of kidney grafts from living donors
Background. Cardiovascular (CV) risk remains high in renal transplant patients despite a clear improvement conferred by transplantation. This risk is attributed mostly to recipient-related risk factors. Donor vascular characteristics, such as arterial stiffness, have been poorly investigated in this...
محفوظ في:
| المؤلف الرئيسي: | |
|---|---|
| مؤلفون آخرون: | , , |
| التنسيق: | article |
| منشور في: |
2012
|
| الوصول للمادة أونلاين: | http://hdl.handle.net/10725/10753 https://doi.org/10.1093/ndt/gfr578 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://academic.oup.com/ndt/article/27/5/2095/1841343 |
| الوسوم: |
إضافة وسم
لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!
|
| _version_ | 1864513487416328192 |
|---|---|
| author | Bahous, Sola Aoun |
| author2 | Stephan, Antoine Blacher, Jacques Safar, Michel |
| author2_role | author author author |
| author_facet | Bahous, Sola Aoun Stephan, Antoine Blacher, Jacques Safar, Michel |
| author_role | author |
| dc.creator.none.fl_str_mv | Bahous, Sola Aoun Stephan, Antoine Blacher, Jacques Safar, Michel |
| dc.date.none.fl_str_mv | 2012 2019-06-07T08:50:03Z 2019-06-07T08:50:03Z 2019-06-07 |
| dc.identifier.none.fl_str_mv | 1460-2385 http://hdl.handle.net/10725/10753 https://doi.org/10.1093/ndt/gfr578 Aoun Bahous, S., Stephan, A., Blacher, J., & Safar, M. (2011). Cardiovascular and renal outcome in recipients of kidney grafts from living donors: role of aortic stiffness. Nephrology Dialysis Transplantation, 27(5), 2095-2100. http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://academic.oup.com/ndt/article/27/5/2095/1841343 |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | Nephrology Dialysis Transplantation |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | Cardiovascular and renal outcome in recipients of kidney grafts from living donors role of aortic stiffness |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Background. Cardiovascular (CV) risk remains high in renal transplant patients despite a clear improvement conferred by transplantation. This risk is attributed mostly to recipient-related risk factors. Donor vascular characteristics, such as arterial stiffness, have been poorly investigated in this regard. Methods. Recipients of living-related (n = 75) and living-unrelated (n = 20) kidney grafts were recruited at a mean time of 107 ± 41 months after transplantation for baseline evaluation and follow-up for the occurrence of the following composite outcome: myocardial infarction, stroke, CV death, doubling of serum creatinine or development of end-stage renal disease (ESRD). At inclusion, recipients and their corresponding donors underwent complete history, physical examination, laboratory tests and non-invasive measurement of aortic pulse wave velocity (PWV). Results. During a mean follow-up of 56 ± 18 months, 20 recipients doubled their serum creatinine, of whom 16 reached ESRD, and 9 suffered of a new CV event (5 of which were fatal). Cox proportional hazards regression analysis showed that, in addition to recipient-related parameters, such as the presence of CV event and the estimated glomerular filtration rate at inclusion, donor aortic PWV was a strong and independent predictor of the composite recipient outcome. Conclusions. Donor large artery stiffness may predict recipient CV and graft outcome. This finding demonstrates the tight link that exists between the vascular system and the kidneys and suggests that donor contribution to recipient outcome goes beyond simple parameters like age, gender and even familial or non-familial donor type. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_0d2534ccb62f4f08327ac1e89f79e4bd |
| identifier_str_mv | 1460-2385 Aoun Bahous, S., Stephan, A., Blacher, J., & Safar, M. (2011). Cardiovascular and renal outcome in recipients of kidney grafts from living donors: role of aortic stiffness. Nephrology Dialysis Transplantation, 27(5), 2095-2100. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/10753 |
| publishDate | 2012 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Cardiovascular and renal outcome in recipients of kidney grafts from living donorsrole of aortic stiffnessBahous, Sola AounStephan, AntoineBlacher, JacquesSafar, MichelBackground. Cardiovascular (CV) risk remains high in renal transplant patients despite a clear improvement conferred by transplantation. This risk is attributed mostly to recipient-related risk factors. Donor vascular characteristics, such as arterial stiffness, have been poorly investigated in this regard. Methods. Recipients of living-related (n = 75) and living-unrelated (n = 20) kidney grafts were recruited at a mean time of 107 ± 41 months after transplantation for baseline evaluation and follow-up for the occurrence of the following composite outcome: myocardial infarction, stroke, CV death, doubling of serum creatinine or development of end-stage renal disease (ESRD). At inclusion, recipients and their corresponding donors underwent complete history, physical examination, laboratory tests and non-invasive measurement of aortic pulse wave velocity (PWV). Results. During a mean follow-up of 56 ± 18 months, 20 recipients doubled their serum creatinine, of whom 16 reached ESRD, and 9 suffered of a new CV event (5 of which were fatal). Cox proportional hazards regression analysis showed that, in addition to recipient-related parameters, such as the presence of CV event and the estimated glomerular filtration rate at inclusion, donor aortic PWV was a strong and independent predictor of the composite recipient outcome. Conclusions. Donor large artery stiffness may predict recipient CV and graft outcome. This finding demonstrates the tight link that exists between the vascular system and the kidneys and suggests that donor contribution to recipient outcome goes beyond simple parameters like age, gender and even familial or non-familial donor type.PublishedN/A2019-06-07T08:50:03Z2019-06-07T08:50:03Z20122019-06-07Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1460-2385http://hdl.handle.net/10725/10753https://doi.org/10.1093/ndt/gfr578Aoun Bahous, S., Stephan, A., Blacher, J., & Safar, M. (2011). Cardiovascular and renal outcome in recipients of kidney grafts from living donors: role of aortic stiffness. Nephrology Dialysis Transplantation, 27(5), 2095-2100.http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.phphttps://academic.oup.com/ndt/article/27/5/2095/1841343enNephrology Dialysis Transplantationinfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/107532021-03-19T10:45:16Z |
| spellingShingle | Cardiovascular and renal outcome in recipients of kidney grafts from living donors Bahous, Sola Aoun |
| status_str | publishedVersion |
| title | Cardiovascular and renal outcome in recipients of kidney grafts from living donors |
| title_full | Cardiovascular and renal outcome in recipients of kidney grafts from living donors |
| title_fullStr | Cardiovascular and renal outcome in recipients of kidney grafts from living donors |
| title_full_unstemmed | Cardiovascular and renal outcome in recipients of kidney grafts from living donors |
| title_short | Cardiovascular and renal outcome in recipients of kidney grafts from living donors |
| title_sort | Cardiovascular and renal outcome in recipients of kidney grafts from living donors |
| url | http://hdl.handle.net/10725/10753 https://doi.org/10.1093/ndt/gfr578 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://academic.oup.com/ndt/article/27/5/2095/1841343 |