Species- and tissue-dependent effects of NO and cyclic GMP on cardiac ion channels
Biochemical studies have established the presence of a NO pathway in the heart, including sources of NO and various effectors. Several cardiac ion channels have been shown to be modified by NO, such as L-type Ca2+, ATP-sensitive K+, and pacemaker f-channels. Some of these effects are mediated by cGM...
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2005
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| Online Access: | http://hdl.handle.net/10725/6355 https://doi.org/10.1016/j.cbpb.2005.04.012 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://www.sciencedirect.com/science/article/pii/S1095643305000966 |
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| author | Fischmeister, Rodolphe |
| author2 | Castro, Liliana Abi-Gerges, Aniella Rochais, Francesca Vandecasteele, Gregoire |
| author2_role | author author author author |
| author_facet | Fischmeister, Rodolphe Castro, Liliana Abi-Gerges, Aniella Rochais, Francesca Vandecasteele, Gregoire |
| author_role | author |
| dc.creator.none.fl_str_mv | Fischmeister, Rodolphe Castro, Liliana Abi-Gerges, Aniella Rochais, Francesca Vandecasteele, Gregoire |
| dc.date.none.fl_str_mv | 2005 2017-10-19T10:06:46Z 2017-10-19T10:06:46Z 2017-10-19 |
| dc.identifier.none.fl_str_mv | 1531-4332 http://hdl.handle.net/10725/6355 https://doi.org/10.1016/j.cbpb.2005.04.012 Fischmeister, R., Castro, L., Abi-Gerges, A., Rochais, F., & Vandecasteele, G. (2005). Species-and tissue-dependent effects of NO and cyclic GMP on cardiac ion channels. Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, 142(2), 136-143. http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://www.sciencedirect.com/science/article/pii/S1095643305000966 |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | Species- and tissue-dependent effects of NO and cyclic GMP on cardiac ion channels |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Biochemical studies have established the presence of a NO pathway in the heart, including sources of NO and various effectors. Several cardiac ion channels have been shown to be modified by NO, such as L-type Ca2+, ATP-sensitive K+, and pacemaker f-channels. Some of these effects are mediated by cGMP, through the activity of three main proteins: the cGMP-dependent protein kinase (PKG), the cGMP-stimulated phosphodiesterase (PDE2) and the cGMP-inhibited PDE (PDE3). Other effects appear independent of cGMP, as for instance the NO modulation of the ryanodine receptor-Ca2+ channel. In the case of the cardiac L-type Ca2+ channel current (ICa,L), both cGMP-dependent and cGMP-independent effects have been reported, with important tissue and species specificity. For instance, in rabbit sinoatrial myocytes, NO inhibits the β-adrenergic stimulation of ICa,L through activation of PDE2. In cat and human atrial myocytes, NO potentiates the cAMP-dependent stimulation of ICa,L through inhibition of PDE3. In rabbit atrial myocytes, NO enhances ICa,L in a cAMP-independent manner through the activation of PKG. In ventricular myocytes, NO exerts opposite effects on ICa,L: an inhibition mediated by PKG in mammalian myocytes but by PDE2 in frog myocytes; a stimulation attributed to PDE3 inhibition in frog ventricular myocytes but to a direct effect of NO in ferret ventricular myocytes. Finally, NO can also regulate cardiac ion channels by a direct action on G-proteins and adenylyl cyclase. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_0d6106830f0cefc2e86136cc47810c71 |
| identifier_str_mv | 1531-4332 Fischmeister, R., Castro, L., Abi-Gerges, A., Rochais, F., & Vandecasteele, G. (2005). Species-and tissue-dependent effects of NO and cyclic GMP on cardiac ion channels. Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, 142(2), 136-143. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/6355 |
| publishDate | 2005 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Species- and tissue-dependent effects of NO and cyclic GMP on cardiac ion channelsFischmeister, RodolpheCastro, LilianaAbi-Gerges, AniellaRochais, FrancescaVandecasteele, GregoireBiochemical studies have established the presence of a NO pathway in the heart, including sources of NO and various effectors. Several cardiac ion channels have been shown to be modified by NO, such as L-type Ca2+, ATP-sensitive K+, and pacemaker f-channels. Some of these effects are mediated by cGMP, through the activity of three main proteins: the cGMP-dependent protein kinase (PKG), the cGMP-stimulated phosphodiesterase (PDE2) and the cGMP-inhibited PDE (PDE3). Other effects appear independent of cGMP, as for instance the NO modulation of the ryanodine receptor-Ca2+ channel. In the case of the cardiac L-type Ca2+ channel current (ICa,L), both cGMP-dependent and cGMP-independent effects have been reported, with important tissue and species specificity. For instance, in rabbit sinoatrial myocytes, NO inhibits the β-adrenergic stimulation of ICa,L through activation of PDE2. In cat and human atrial myocytes, NO potentiates the cAMP-dependent stimulation of ICa,L through inhibition of PDE3. In rabbit atrial myocytes, NO enhances ICa,L in a cAMP-independent manner through the activation of PKG. In ventricular myocytes, NO exerts opposite effects on ICa,L: an inhibition mediated by PKG in mammalian myocytes but by PDE2 in frog myocytes; a stimulation attributed to PDE3 inhibition in frog ventricular myocytes but to a direct effect of NO in ferret ventricular myocytes. Finally, NO can also regulate cardiac ion channels by a direct action on G-proteins and adenylyl cyclase.PublishedN/A2017-10-19T10:06:46Z2017-10-19T10:06:46Z20052017-10-19Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1531-4332http://hdl.handle.net/10725/6355https://doi.org/10.1016/j.cbpb.2005.04.012Fischmeister, R., Castro, L., Abi-Gerges, A., Rochais, F., & Vandecasteele, G. (2005). Species-and tissue-dependent effects of NO and cyclic GMP on cardiac ion channels. Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, 142(2), 136-143.http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.phphttp://www.sciencedirect.com/science/article/pii/S1095643305000966enComparative Biochemistry and Physiology Part A: Molecular & Integrative Physiologyinfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/63552021-03-19T10:03:28Z |
| spellingShingle | Species- and tissue-dependent effects of NO and cyclic GMP on cardiac ion channels Fischmeister, Rodolphe |
| status_str | publishedVersion |
| title | Species- and tissue-dependent effects of NO and cyclic GMP on cardiac ion channels |
| title_full | Species- and tissue-dependent effects of NO and cyclic GMP on cardiac ion channels |
| title_fullStr | Species- and tissue-dependent effects of NO and cyclic GMP on cardiac ion channels |
| title_full_unstemmed | Species- and tissue-dependent effects of NO and cyclic GMP on cardiac ion channels |
| title_short | Species- and tissue-dependent effects of NO and cyclic GMP on cardiac ion channels |
| title_sort | Species- and tissue-dependent effects of NO and cyclic GMP on cardiac ion channels |
| url | http://hdl.handle.net/10725/6355 https://doi.org/10.1016/j.cbpb.2005.04.012 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://www.sciencedirect.com/science/article/pii/S1095643305000966 |