Hepatic adenoma and focal nodular hyperplasia
Focal nodular hyperplasia (FNH) and adenoma are rare benign hepatic tumors, and the standards for diagnosis and treatment still remain controversial. Usually adenoma is an indication for resection, due to its tendency to bleed and to degenerate; FNH, on the contrary, may be treated conservatively. P...
محفوظ في:
| المؤلف الرئيسي: | |
|---|---|
| مؤلفون آخرون: | , , , , , , , , , |
| التنسيق: | article |
| منشور في: |
1997
|
| الوصول للمادة أونلاين: | http://hdl.handle.net/10725/10773 https://doi.org/10.1002/lt.500030209 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://aasldpubs.onlinelibrary.wiley.com/doi/pdf/10.1002/lt.500030209 |
| الوسوم: |
إضافة وسم
لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!
|
| _version_ | 1864513487428911104 |
|---|---|
| author | De Carlis, Luciano |
| author2 | Pirotta, Vincenzo Rondinara, GianFranco Sansalone, Cosimo V. Collela, Giovanni Maione, Giuseppe Slim, Abdallah O. Rampoldi, Antonio Cazzulani, Alberto Belli, Luca Forti, Domenico |
| author2_role | author author author author author author author author author author |
| author_facet | De Carlis, Luciano Pirotta, Vincenzo Rondinara, GianFranco Sansalone, Cosimo V. Collela, Giovanni Maione, Giuseppe Slim, Abdallah O. Rampoldi, Antonio Cazzulani, Alberto Belli, Luca Forti, Domenico |
| author_role | author |
| dc.creator.none.fl_str_mv | De Carlis, Luciano Pirotta, Vincenzo Rondinara, GianFranco Sansalone, Cosimo V. Collela, Giovanni Maione, Giuseppe Slim, Abdallah O. Rampoldi, Antonio Cazzulani, Alberto Belli, Luca Forti, Domenico |
| dc.date.none.fl_str_mv | 1997 2019-06-11T10:23:09Z 2019-06-11T10:23:09Z 2019-06-11 |
| dc.identifier.none.fl_str_mv | 1074-3022 http://hdl.handle.net/10725/10773 https://doi.org/10.1002/lt.500030209 De Carlis, L., Pirotta, V., Rondinara, G. F., Sansalone, C. V., Colella, G., Maione, G., ... & Forti, D. (1997). Hepatic adenoma and focal nodular hyperplasia: diagnosis and criteria for treatment. Liver Transplantation and Surgery, 3(2), 160-165. http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://aasldpubs.onlinelibrary.wiley.com/doi/pdf/10.1002/lt.500030209 |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | Liver Transplantation and Surgery |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | Hepatic adenoma and focal nodular hyperplasia diagnosis and criteria for treatment |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Focal nodular hyperplasia (FNH) and adenoma are rare benign hepatic tumors, and the standards for diagnosis and treatment still remain controversial. Usually adenoma is an indication for resection, due to its tendency to bleed and to degenerate; FNH, on the contrary, may be treated conservatively. Preoperation differential diagnosis is, however, difficult, often impossible. Materials and methods. Thirty-eight patients with presumed hepatic adenoma and/or FNH were studied at our department from 1984 to 1996. Preoperative assessment included clinical evaluation and symptoms, laboratory tests, liver biopsy, ultrasound scan, computed tomography scan, magnetic resonance imaging, scintigraphy, and angiography. Thirteen patients had a presumed diagnosis of FNH, 16 of adenoma, and 9 of undetermined benign lesions; 27 had hepatic resections (3 with laparoscopic technique), and 11 were not operated on and are actually under a strict follow-up observation. Results. The final diagnosis was 19 FNH and 19 adenomas (2 of whichcontained areas of hepatocarcinoma). Presumed diagnosis was confirmed in 71% of cases. Use of oral contraceptives, abdominal symptoms, and pathologic liver test results were more frequent in patients with adenomas. There were no deaths after surgery. All resected patients were tumor free during the follow-up, and in 10 of the 11 nonoperated cases, the size of the nodules remained unchanged. We conclude that precise diagnosis of these benign liver tumors remains difficult and sometimes impossible, despite new imaging techniques. Hepatic resections can be performed under very safe conditions; laparoscopic surgery may play a role in selected cases. Adenomas and uncertain cases are clear indications for surgery. Only when a diagnosis of FNH can be firmly confirmed in asymptomatic patientsis strict observation without surgery recommended. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_0ea71b9a6b2b0aa45efb707a0d565994 |
| identifier_str_mv | 1074-3022 De Carlis, L., Pirotta, V., Rondinara, G. F., Sansalone, C. V., Colella, G., Maione, G., ... & Forti, D. (1997). Hepatic adenoma and focal nodular hyperplasia: diagnosis and criteria for treatment. Liver Transplantation and Surgery, 3(2), 160-165. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/10773 |
| publishDate | 1997 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Hepatic adenoma and focal nodular hyperplasiadiagnosis and criteria for treatmentDe Carlis, LucianoPirotta, VincenzoRondinara, GianFrancoSansalone, Cosimo V.Collela, GiovanniMaione, GiuseppeSlim, Abdallah O.Rampoldi, AntonioCazzulani, AlbertoBelli, LucaForti, DomenicoFocal nodular hyperplasia (FNH) and adenoma are rare benign hepatic tumors, and the standards for diagnosis and treatment still remain controversial. Usually adenoma is an indication for resection, due to its tendency to bleed and to degenerate; FNH, on the contrary, may be treated conservatively. Preoperation differential diagnosis is, however, difficult, often impossible. Materials and methods. Thirty-eight patients with presumed hepatic adenoma and/or FNH were studied at our department from 1984 to 1996. Preoperative assessment included clinical evaluation and symptoms, laboratory tests, liver biopsy, ultrasound scan, computed tomography scan, magnetic resonance imaging, scintigraphy, and angiography. Thirteen patients had a presumed diagnosis of FNH, 16 of adenoma, and 9 of undetermined benign lesions; 27 had hepatic resections (3 with laparoscopic technique), and 11 were not operated on and are actually under a strict follow-up observation. Results. The final diagnosis was 19 FNH and 19 adenomas (2 of whichcontained areas of hepatocarcinoma). Presumed diagnosis was confirmed in 71% of cases. Use of oral contraceptives, abdominal symptoms, and pathologic liver test results were more frequent in patients with adenomas. There were no deaths after surgery. All resected patients were tumor free during the follow-up, and in 10 of the 11 nonoperated cases, the size of the nodules remained unchanged. We conclude that precise diagnosis of these benign liver tumors remains difficult and sometimes impossible, despite new imaging techniques. Hepatic resections can be performed under very safe conditions; laparoscopic surgery may play a role in selected cases. Adenomas and uncertain cases are clear indications for surgery. Only when a diagnosis of FNH can be firmly confirmed in asymptomatic patientsis strict observation without surgery recommended.PublishedN/A2019-06-11T10:23:09Z2019-06-11T10:23:09Z19972019-06-11Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1074-3022http://hdl.handle.net/10725/10773https://doi.org/10.1002/lt.500030209De Carlis, L., Pirotta, V., Rondinara, G. F., Sansalone, C. V., Colella, G., Maione, G., ... & Forti, D. (1997). Hepatic adenoma and focal nodular hyperplasia: diagnosis and criteria for treatment. Liver Transplantation and Surgery, 3(2), 160-165.http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.phphttps://aasldpubs.onlinelibrary.wiley.com/doi/pdf/10.1002/lt.500030209enLiver Transplantation and Surgeryinfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/107732022-10-12T11:00:47Z |
| spellingShingle | Hepatic adenoma and focal nodular hyperplasia De Carlis, Luciano |
| status_str | publishedVersion |
| title | Hepatic adenoma and focal nodular hyperplasia |
| title_full | Hepatic adenoma and focal nodular hyperplasia |
| title_fullStr | Hepatic adenoma and focal nodular hyperplasia |
| title_full_unstemmed | Hepatic adenoma and focal nodular hyperplasia |
| title_short | Hepatic adenoma and focal nodular hyperplasia |
| title_sort | Hepatic adenoma and focal nodular hyperplasia |
| url | http://hdl.handle.net/10725/10773 https://doi.org/10.1002/lt.500030209 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://aasldpubs.onlinelibrary.wiley.com/doi/pdf/10.1002/lt.500030209 |