Acute exposure to cigarette smoking followed by myocardial infarction aggravates renal damage in an In vivo mouse model
Cigarette smoking (S) is a risk factor for progressive chronic kidney disease, renal dysfunction, and renal failure. In this study, the effect of smoking on kidney function was investigated in a mouse model of myocardial infarction (MI) using 4 groups: control (C), smoking (S), MI, and S+MI. Histolo...
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| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , , , , |
| التنسيق: | article |
| منشور في: |
2017
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| الوصول للمادة أونلاين: | http://hdl.handle.net/10725/10661 https://doi.org/10.1155/2017/5135241 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://www.hindawi.com/journals/omcl/2017/5135241/abs/ |
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| _version_ | 1864513487054569472 |
|---|---|
| author | Kobeissy, Firas |
| author2 | Shaito, Abdullah Kaplan, Abdullah Baki, Lama Hayek, Hassan Dagher-Hamalian, Carole Nehme, Ali |
| author2_role | author author author author author author |
| author_facet | Kobeissy, Firas Shaito, Abdullah Kaplan, Abdullah Baki, Lama Hayek, Hassan Dagher-Hamalian, Carole Nehme, Ali |
| author_role | author |
| dc.creator.none.fl_str_mv | Kobeissy, Firas Shaito, Abdullah Kaplan, Abdullah Baki, Lama Hayek, Hassan Dagher-Hamalian, Carole Nehme, Ali |
| dc.date.none.fl_str_mv | 2017 2019-05-23T12:00:20Z 2019-05-23T12:00:20Z 2019-05-23 |
| dc.identifier.none.fl_str_mv | 1942-0994 http://hdl.handle.net/10725/10661 https://doi.org/10.1155/2017/5135241 Kobeissy, F., Shaito, A., Kaplan, A., Baki, L., Hayek, H., Dagher-Hamalian, C., ... & Zeidan, A. (2017). Acute exposure to cigarette smoking followed by myocardial infarction aggravates renal damage in an in vivo mouse model. Oxidative medicine and cellular longevity, 2017. http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://www.hindawi.com/journals/omcl/2017/5135241/abs/ |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | Oxidative Medicine and Cellular Longevity |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | Acute exposure to cigarette smoking followed by myocardial infarction aggravates renal damage in an In vivo mouse model |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Cigarette smoking (S) is a risk factor for progressive chronic kidney disease, renal dysfunction, and renal failure. In this study, the effect of smoking on kidney function was investigated in a mouse model of myocardial infarction (MI) using 4 groups: control (C), smoking (S), MI, and S+MI. Histological analysis of S+MI group showed alterations in kidney structure including swelling of the proximal convoluted tubules (PCTs), thinning of the epithelial lining, focal loss of the brush border of PCTs, and patchy glomerular retraction. Molecular analysis revealed that nephrin expression was significantly reduced in the S+MI group, whereas sodium-hydrogen exchanger-1 (NHE-1) was significantly increased, suggesting altered glomerular filtration and kidney functions. Moreover, S+MI group, but not S alone, showed a significant increase in the expression of connective tissue growth factor (CTGF) and fibrotic proteins fibronectin (FN) and α-smooth muscle actin (SMA), in comparison to controls, in addition to a significant increase in mRNA levels of IL-6 and TNF-α inflammatory markers. Finally, reactive oxygen species (ROS) production was significantly accentuated in S+MI group concomitant with a significant increase in NOX-4 protein levels. In conclusion, smoking aggravates murine acute renal damage caused by MI at the structural and molecular levels by exacerbating renal dysfunction. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_12b4ebda86e4ed8b26d35315c3581536 |
| identifier_str_mv | 1942-0994 Kobeissy, F., Shaito, A., Kaplan, A., Baki, L., Hayek, H., Dagher-Hamalian, C., ... & Zeidan, A. (2017). Acute exposure to cigarette smoking followed by myocardial infarction aggravates renal damage in an in vivo mouse model. Oxidative medicine and cellular longevity, 2017. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/10661 |
| publishDate | 2017 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Acute exposure to cigarette smoking followed by myocardial infarction aggravates renal damage in an In vivo mouse modelKobeissy, FirasShaito, AbdullahKaplan, AbdullahBaki, LamaHayek, HassanDagher-Hamalian, CaroleNehme, AliCigarette smoking (S) is a risk factor for progressive chronic kidney disease, renal dysfunction, and renal failure. In this study, the effect of smoking on kidney function was investigated in a mouse model of myocardial infarction (MI) using 4 groups: control (C), smoking (S), MI, and S+MI. Histological analysis of S+MI group showed alterations in kidney structure including swelling of the proximal convoluted tubules (PCTs), thinning of the epithelial lining, focal loss of the brush border of PCTs, and patchy glomerular retraction. Molecular analysis revealed that nephrin expression was significantly reduced in the S+MI group, whereas sodium-hydrogen exchanger-1 (NHE-1) was significantly increased, suggesting altered glomerular filtration and kidney functions. Moreover, S+MI group, but not S alone, showed a significant increase in the expression of connective tissue growth factor (CTGF) and fibrotic proteins fibronectin (FN) and α-smooth muscle actin (SMA), in comparison to controls, in addition to a significant increase in mRNA levels of IL-6 and TNF-α inflammatory markers. Finally, reactive oxygen species (ROS) production was significantly accentuated in S+MI group concomitant with a significant increase in NOX-4 protein levels. In conclusion, smoking aggravates murine acute renal damage caused by MI at the structural and molecular levels by exacerbating renal dysfunction.PublishedN/A2019-05-23T12:00:20Z2019-05-23T12:00:20Z20172019-05-23Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1942-0994http://hdl.handle.net/10725/10661https://doi.org/10.1155/2017/5135241Kobeissy, F., Shaito, A., Kaplan, A., Baki, L., Hayek, H., Dagher-Hamalian, C., ... & Zeidan, A. (2017). Acute exposure to cigarette smoking followed by myocardial infarction aggravates renal damage in an in vivo mouse model. Oxidative medicine and cellular longevity, 2017.http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.phphttps://www.hindawi.com/journals/omcl/2017/5135241/abs/enOxidative Medicine and Cellular Longevityinfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/106612021-03-19T10:45:25Z |
| spellingShingle | Acute exposure to cigarette smoking followed by myocardial infarction aggravates renal damage in an In vivo mouse model Kobeissy, Firas |
| status_str | publishedVersion |
| title | Acute exposure to cigarette smoking followed by myocardial infarction aggravates renal damage in an In vivo mouse model |
| title_full | Acute exposure to cigarette smoking followed by myocardial infarction aggravates renal damage in an In vivo mouse model |
| title_fullStr | Acute exposure to cigarette smoking followed by myocardial infarction aggravates renal damage in an In vivo mouse model |
| title_full_unstemmed | Acute exposure to cigarette smoking followed by myocardial infarction aggravates renal damage in an In vivo mouse model |
| title_short | Acute exposure to cigarette smoking followed by myocardial infarction aggravates renal damage in an In vivo mouse model |
| title_sort | Acute exposure to cigarette smoking followed by myocardial infarction aggravates renal damage in an In vivo mouse model |
| url | http://hdl.handle.net/10725/10661 https://doi.org/10.1155/2017/5135241 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://www.hindawi.com/journals/omcl/2017/5135241/abs/ |