Multi-wavelength optical imaging of human tumour xenografts
In vivo optical imaging methods have become a cornerstone of pre-clinical cancer research. Genetically modified cells with fluorescent or bioluminescent reporters allow researchers to non-invasively study tumour proliferation and biochemistry over time. Target-specific fluorescent probes may be used...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , , |
| التنسيق: | article |
| منشور في: |
2011
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| الوصول للمادة أونلاين: | http://hdl.handle.net/10725/11031 https://doi.org/10.1071/CH10449 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://www.publish.csiro.au/ch/ch10449 |
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| _version_ | 1864513487991996416 |
|---|---|
| author | Wang, Wei |
| author2 | Cameron, Arlin G. Wendt, Juliet A. Mawad, Michel E. Ke, Shi |
| author2_role | author author author author |
| author_facet | Wang, Wei Cameron, Arlin G. Wendt, Juliet A. Mawad, Michel E. Ke, Shi |
| author_role | author |
| dc.creator.none.fl_str_mv | Wang, Wei Cameron, Arlin G. Wendt, Juliet A. Mawad, Michel E. Ke, Shi |
| dc.date.none.fl_str_mv | 2011 2019-07-10T11:08:49Z 2019-07-10T11:08:49Z 2019-07-10 |
| dc.identifier.none.fl_str_mv | 1445-0038 http://hdl.handle.net/10725/11031 https://doi.org/10.1071/CH10449 Wang, W., Cameron, A. G., Wendt, J. A., Mawad, M. E., & Ke, S. (2011). Multi-wavelength Optical Imaging of Human Tumour Xenografts. Australian Journal of Chemistry, 64(5), 625-632. http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://www.publish.csiro.au/ch/ch10449 |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | Australian Journal of Chemistry |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | Multi-wavelength optical imaging of human tumour xenografts |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | In vivo optical imaging methods have become a cornerstone of pre-clinical cancer research. Genetically modified cells with fluorescent or bioluminescent reporters allow researchers to non-invasively study tumour proliferation and biochemistry over time. Target-specific fluorescent probes may be used to reveal specific tumour properties such as growth patterns, neovasculature formation, and compartmental probe absorbance. Herein, we demonstrate the simultaneous optical imaging of these tumour properties in a human neuroblastoma model. We used luciferase-positive cancer cells, a neovasculature specific fluorescent probe, and a fluorescent tumour cell target-specific agent, in conjunction with X-ray/CT for anatomical localization. These experiments revealed a detailed map of the tumour progression and biological interactions with imaging agents within the tumour. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_147dcad1e22a66c9e4da33f0ca12dc56 |
| identifier_str_mv | 1445-0038 Wang, W., Cameron, A. G., Wendt, J. A., Mawad, M. E., & Ke, S. (2011). Multi-wavelength Optical Imaging of Human Tumour Xenografts. Australian Journal of Chemistry, 64(5), 625-632. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/11031 |
| publishDate | 2011 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Multi-wavelength optical imaging of human tumour xenograftsWang, WeiCameron, Arlin G.Wendt, Juliet A.Mawad, Michel E.Ke, ShiIn vivo optical imaging methods have become a cornerstone of pre-clinical cancer research. Genetically modified cells with fluorescent or bioluminescent reporters allow researchers to non-invasively study tumour proliferation and biochemistry over time. Target-specific fluorescent probes may be used to reveal specific tumour properties such as growth patterns, neovasculature formation, and compartmental probe absorbance. Herein, we demonstrate the simultaneous optical imaging of these tumour properties in a human neuroblastoma model. We used luciferase-positive cancer cells, a neovasculature specific fluorescent probe, and a fluorescent tumour cell target-specific agent, in conjunction with X-ray/CT for anatomical localization. These experiments revealed a detailed map of the tumour progression and biological interactions with imaging agents within the tumour.PublishedN/A2019-07-10T11:08:49Z2019-07-10T11:08:49Z20112019-07-10Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1445-0038http://hdl.handle.net/10725/11031https://doi.org/10.1071/CH10449Wang, W., Cameron, A. G., Wendt, J. A., Mawad, M. E., & Ke, S. (2011). Multi-wavelength Optical Imaging of Human Tumour Xenografts. Australian Journal of Chemistry, 64(5), 625-632.http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.phphttp://www.publish.csiro.au/ch/ch10449enAustralian Journal of Chemistryinfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/110312021-03-19T10:45:26Z |
| spellingShingle | Multi-wavelength optical imaging of human tumour xenografts Wang, Wei |
| status_str | publishedVersion |
| title | Multi-wavelength optical imaging of human tumour xenografts |
| title_full | Multi-wavelength optical imaging of human tumour xenografts |
| title_fullStr | Multi-wavelength optical imaging of human tumour xenografts |
| title_full_unstemmed | Multi-wavelength optical imaging of human tumour xenografts |
| title_short | Multi-wavelength optical imaging of human tumour xenografts |
| title_sort | Multi-wavelength optical imaging of human tumour xenografts |
| url | http://hdl.handle.net/10725/11031 https://doi.org/10.1071/CH10449 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://www.publish.csiro.au/ch/ch10449 |