The association of hypertension with renin–angiotensin system gene polymorphisms in the Lebanese population
Aim: The study objective was to examine the association of hypertension in the Lebanese population with three renin–angiotensin system gene polymorphisms (RAS): angiotensin-converting enzyme (ACE), angiotensinogen (AGT) and angiotensin-receptor type 1 (AT1R). Methods: A total of 270 subjects (124 hy...
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2011
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| Online Access: | http://hdl.handle.net/10725/4394 http://dx.doi.org/10.1177/1470320311408465 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://jra.sagepub.com/content/early/2011/05/20/1470320311408465.abstract |
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| Summary: | Aim: The study objective was to examine the association of hypertension in the Lebanese population with three renin–angiotensin system gene polymorphisms (RAS): angiotensin-converting enzyme (ACE), angiotensinogen (AGT) and angiotensin-receptor type 1 (AT1R). Methods: A total of 270 subjects (124 hypertensive vs 146 normotensive) were genotyped for ACE insertion (I)/deletion (D), AGT (M235T), and AT1R (A1166C) gene polymorphisms by polymerase chain reaction and restriction fragment length polymorphism. Results: The studied genes showed no deviation from Hardy–Weinberg equilibrium. No association could be reported with the ACE I/D polymorphism, although the D allele frequency was high (77%) in patients. AGT TT genotype prevalence was found to be lower in hypertensive versus normotensive subjects (p < 0.0001). AT1R CC and AC genotypes were significantly more frequent in hypertensive than normotensive subjects (p < 0.0001). Conclusion: The first conducted study on the RAS gene polymorphisms in Lebanese hypertensive patients demonstrated a possible association of the AGT T and AT1R C alleles with hypertension. |
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