The association of hypertension with renin–angiotensin system gene polymorphisms in the Lebanese population
Aim: The study objective was to examine the association of hypertension in the Lebanese population with three renin–angiotensin system gene polymorphisms (RAS): angiotensin-converting enzyme (ACE), angiotensinogen (AGT) and angiotensin-receptor type 1 (AT1R). Methods: A total of 270 subjects (124 hy...
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2011
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| Online Access: | http://hdl.handle.net/10725/4394 http://dx.doi.org/10.1177/1470320311408465 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://jra.sagepub.com/content/early/2011/05/20/1470320311408465.abstract |
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| _version_ | 1864513463302225920 |
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| author | Saab, YB |
| author2 | Gard, PR Overall, ADJ |
| author2_role | author author |
| author_facet | Saab, YB Gard, PR Overall, ADJ |
| author_role | author |
| dc.creator.none.fl_str_mv | Saab, YB Gard, PR Overall, ADJ |
| dc.date.none.fl_str_mv | 2011 2016-09-26T09:49:06Z 2016-09-26T09:49:06Z 2016-09-26 |
| dc.identifier.none.fl_str_mv | 1470-3203 http://hdl.handle.net/10725/4394 http://dx.doi.org/10.1177/1470320311408465 Saab, Y. B., Gard, P. R., & Overall, A. D. J. (2011). The association of hypertension with renin–angiotensin system gene polymorphisms in the Lebanese population. Journal of Renin-Angiotensin-Aldosterone System, 1470320311408465. http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://jra.sagepub.com/content/early/2011/05/20/1470320311408465.abstract |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | Journal of Renin-Angiotensin-Aldosterone System |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | The association of hypertension with renin–angiotensin system gene polymorphisms in the Lebanese population |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Aim: The study objective was to examine the association of hypertension in the Lebanese population with three renin–angiotensin system gene polymorphisms (RAS): angiotensin-converting enzyme (ACE), angiotensinogen (AGT) and angiotensin-receptor type 1 (AT1R). Methods: A total of 270 subjects (124 hypertensive vs 146 normotensive) were genotyped for ACE insertion (I)/deletion (D), AGT (M235T), and AT1R (A1166C) gene polymorphisms by polymerase chain reaction and restriction fragment length polymorphism. Results: The studied genes showed no deviation from Hardy–Weinberg equilibrium. No association could be reported with the ACE I/D polymorphism, although the D allele frequency was high (77%) in patients. AGT TT genotype prevalence was found to be lower in hypertensive versus normotensive subjects (p < 0.0001). AT1R CC and AC genotypes were significantly more frequent in hypertensive than normotensive subjects (p < 0.0001). Conclusion: The first conducted study on the RAS gene polymorphisms in Lebanese hypertensive patients demonstrated a possible association of the AGT T and AT1R C alleles with hypertension. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_14d3597e99c61fee172c4b049819919d |
| identifier_str_mv | 1470-3203 Saab, Y. B., Gard, P. R., & Overall, A. D. J. (2011). The association of hypertension with renin–angiotensin system gene polymorphisms in the Lebanese population. Journal of Renin-Angiotensin-Aldosterone System, 1470320311408465. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/4394 |
| publishDate | 2011 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | The association of hypertension with renin–angiotensin system gene polymorphisms in the Lebanese populationSaab, YBGard, PROverall, ADJAim: The study objective was to examine the association of hypertension in the Lebanese population with three renin–angiotensin system gene polymorphisms (RAS): angiotensin-converting enzyme (ACE), angiotensinogen (AGT) and angiotensin-receptor type 1 (AT1R). Methods: A total of 270 subjects (124 hypertensive vs 146 normotensive) were genotyped for ACE insertion (I)/deletion (D), AGT (M235T), and AT1R (A1166C) gene polymorphisms by polymerase chain reaction and restriction fragment length polymorphism. Results: The studied genes showed no deviation from Hardy–Weinberg equilibrium. No association could be reported with the ACE I/D polymorphism, although the D allele frequency was high (77%) in patients. AGT TT genotype prevalence was found to be lower in hypertensive versus normotensive subjects (p < 0.0001). AT1R CC and AC genotypes were significantly more frequent in hypertensive than normotensive subjects (p < 0.0001). Conclusion: The first conducted study on the RAS gene polymorphisms in Lebanese hypertensive patients demonstrated a possible association of the AGT T and AT1R C alleles with hypertension.PublishedN/A2016-09-26T09:49:06Z2016-09-26T09:49:06Z20112016-09-26Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1470-3203http://hdl.handle.net/10725/4394http://dx.doi.org/10.1177/1470320311408465Saab, Y. B., Gard, P. R., & Overall, A. D. J. (2011). The association of hypertension with renin–angiotensin system gene polymorphisms in the Lebanese population. Journal of Renin-Angiotensin-Aldosterone System, 1470320311408465.http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.phphttp://jra.sagepub.com/content/early/2011/05/20/1470320311408465.abstractenJournal of Renin-Angiotensin-Aldosterone Systeminfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/43942021-03-19T10:03:17Z |
| spellingShingle | The association of hypertension with renin–angiotensin system gene polymorphisms in the Lebanese population Saab, YB |
| status_str | publishedVersion |
| title | The association of hypertension with renin–angiotensin system gene polymorphisms in the Lebanese population |
| title_full | The association of hypertension with renin–angiotensin system gene polymorphisms in the Lebanese population |
| title_fullStr | The association of hypertension with renin–angiotensin system gene polymorphisms in the Lebanese population |
| title_full_unstemmed | The association of hypertension with renin–angiotensin system gene polymorphisms in the Lebanese population |
| title_short | The association of hypertension with renin–angiotensin system gene polymorphisms in the Lebanese population |
| title_sort | The association of hypertension with renin–angiotensin system gene polymorphisms in the Lebanese population |
| url | http://hdl.handle.net/10725/4394 http://dx.doi.org/10.1177/1470320311408465 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://jra.sagepub.com/content/early/2011/05/20/1470320311408465.abstract |