Wild carrot oil extract is selectively cytotoxic to human acute myeloid leukemia cells
In this study, we used Daucus carota oil extract (DCOE) to target acute myeloid leukemia (AML) cells. All the AML cell lines tested were sensitive to the extract while peripheral mononuclear cells were not. Analysis of mechanism of cell death showed an increase in cells positive for annexinV and for...
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2015
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| Online Access: | http://hdl.handle.net/10725/2740 http://dx.doi.org/10.7314/APJCP.2015.16.2.761 https://pubmed.ncbi.nlm.nih.gov/25684522/ |
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| _version_ | 1864513459133087744 |
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| author | Tawil, Mirna |
| author2 | Bekdash, Amira Mroueh, Mohamad Daher, Costantine F. Abi-Habib, Ralph J. |
| author2_role | author author author author |
| author_facet | Tawil, Mirna Bekdash, Amira Mroueh, Mohamad Daher, Costantine F. Abi-Habib, Ralph J. |
| author_role | author |
| dc.creator.none.fl_str_mv | Tawil, Mirna Bekdash, Amira Mroueh, Mohamad Daher, Costantine F. Abi-Habib, Ralph J. |
| dc.date.none.fl_str_mv | 2015-12-01T07:56:56Z 2015-12-01T07:56:56Z 2015 2015-12-01 |
| dc.identifier.none.fl_str_mv | 1513-7368 http://hdl.handle.net/10725/2740 http://dx.doi.org/10.7314/APJCP.2015.16.2.761 Tawil, M., Bekdash, A., Mroueh, M., Daher, C. F., & Abi-Habib, R. J. (2014). Wild Carrot Oil Extract is Selectively Cytotoxic to Human Acute Myeloid Leukemia Cells. Asian Pacific journal of cancer prevention: APJCP, 16(2), 761-767. https://pubmed.ncbi.nlm.nih.gov/25684522/ |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | Asian Pacific Journal of Cancer Prevention |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | Wild carrot oil extract is selectively cytotoxic to human acute myeloid leukemia cells |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | In this study, we used Daucus carota oil extract (DCOE) to target acute myeloid leukemia (AML) cells. All the AML cell lines tested were sensitive to the extract while peripheral mononuclear cells were not. Analysis of mechanism of cell death showed an increase in cells positive for annexinV and for active caspases, indicating that DCOE induces apoptotic cell death in AML. Inhibition of the MAPK pathway decreased sensitivity of AML cells to DCOE, indicating that cytotoxicity may be dependent on its activity. In conclusion, DCOE induces selective apoptosis in AML cells, possibly through a MAPK-dependent mechanism. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_14ecd3daf206dcab7d4c5dfda3a1b24a |
| identifier_str_mv | 1513-7368 Tawil, M., Bekdash, A., Mroueh, M., Daher, C. F., & Abi-Habib, R. J. (2014). Wild Carrot Oil Extract is Selectively Cytotoxic to Human Acute Myeloid Leukemia Cells. Asian Pacific journal of cancer prevention: APJCP, 16(2), 761-767. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/2740 |
| publishDate | 2015 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Wild carrot oil extract is selectively cytotoxic to human acute myeloid leukemia cellsTawil, MirnaBekdash, AmiraMroueh, MohamadDaher, Costantine F.Abi-Habib, Ralph J.In this study, we used Daucus carota oil extract (DCOE) to target acute myeloid leukemia (AML) cells. All the AML cell lines tested were sensitive to the extract while peripheral mononuclear cells were not. Analysis of mechanism of cell death showed an increase in cells positive for annexinV and for active caspases, indicating that DCOE induces apoptotic cell death in AML. Inhibition of the MAPK pathway decreased sensitivity of AML cells to DCOE, indicating that cytotoxicity may be dependent on its activity. In conclusion, DCOE induces selective apoptosis in AML cells, possibly through a MAPK-dependent mechanism.PublishedN/A2015-12-01T07:56:56Z2015-12-01T07:56:56Z20152015-12-01Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1513-7368http://hdl.handle.net/10725/2740http://dx.doi.org/10.7314/APJCP.2015.16.2.761Tawil, M., Bekdash, A., Mroueh, M., Daher, C. F., & Abi-Habib, R. J. (2014). Wild Carrot Oil Extract is Selectively Cytotoxic to Human Acute Myeloid Leukemia Cells. Asian Pacific journal of cancer prevention: APJCP, 16(2), 761-767.https://pubmed.ncbi.nlm.nih.gov/25684522/enAsian Pacific Journal of Cancer Preventioninfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/27402024-02-01T13:33:42Z |
| spellingShingle | Wild carrot oil extract is selectively cytotoxic to human acute myeloid leukemia cells Tawil, Mirna |
| status_str | publishedVersion |
| title | Wild carrot oil extract is selectively cytotoxic to human acute myeloid leukemia cells |
| title_full | Wild carrot oil extract is selectively cytotoxic to human acute myeloid leukemia cells |
| title_fullStr | Wild carrot oil extract is selectively cytotoxic to human acute myeloid leukemia cells |
| title_full_unstemmed | Wild carrot oil extract is selectively cytotoxic to human acute myeloid leukemia cells |
| title_short | Wild carrot oil extract is selectively cytotoxic to human acute myeloid leukemia cells |
| title_sort | Wild carrot oil extract is selectively cytotoxic to human acute myeloid leukemia cells |
| url | http://hdl.handle.net/10725/2740 http://dx.doi.org/10.7314/APJCP.2015.16.2.761 https://pubmed.ncbi.nlm.nih.gov/25684522/ |