Palladin Regulates Invasion in Glioblastoma Multiforme Through Rho GTPases
Glioblastoma multiforme (GBM), is one of the most fatal types of human cancers. GBM tumors exhibit significant heterogeneity and can arise through two distinct routes, forming what is known as primary glioblastoma and secondary glioblastoma. Palladin is a fairly recent protein that plays an importan...
محفوظ في:
| المؤلف الرئيسي: | |
|---|---|
| التنسيق: | masterThesis |
| منشور في: |
2021
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| الموضوعات: | |
| الوصول للمادة أونلاين: | http://hdl.handle.net/10725/13685 https://doi.org/10.26756/th.2022.227 http://libraries.lau.edu.lb/research/laur/terms-of-use/thesis.php |
| الوسوم: |
إضافة وسم
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| _version_ | 1864513467978874880 |
|---|---|
| author | Farran, Mohammad |
| author_facet | Farran, Mohammad |
| author_role | author |
| dc.creator.none.fl_str_mv | Farran, Mohammad |
| dc.date.none.fl_str_mv | 2021 2021-07-29 2022-06-15T09:20:38Z 2022-06-15T09:20:38Z |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10725/13685 https://doi.org/10.26756/th.2022.227 http://libraries.lau.edu.lb/research/laur/terms-of-use/thesis.php |
| dc.language.none.fl_str_mv | en |
| dc.publisher.none.fl_str_mv | Lebanese American University |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Glioblastoma multiforme Rho GTPases Cancer cells Lebanese American University -- Dissertations Dissertations, Academic |
| dc.title.none.fl_str_mv | Palladin Regulates Invasion in Glioblastoma Multiforme Through Rho GTPases |
| dc.type.none.fl_str_mv | Thesis info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/masterThesis |
| description | Glioblastoma multiforme (GBM), is one of the most fatal types of human cancers. GBM tumors exhibit significant heterogeneity and can arise through two distinct routes, forming what is known as primary glioblastoma and secondary glioblastoma. Palladin is a fairly recent protein that plays an important role in regulating actin and has been implicated in numerous cellular processes like adhesion, motility, invasion, and metastasis. Changes in palladin expression have also been observed in invasive tumors like breast and pancreatic cancer. In this study, we showed that palladin regulates the invasion of glioblastoma cells by affecting invadopodia formation. We also highlighted cross talks between palladin and Rho GTPases like Cdc42 and Rac1 that are also implicated in GBM invasion. This paper offers interesting insights into the role of palladin and Rho GTPases in the complex networks that drive the formation of invadopodia in glioblastoma multiforme, leading to invasion and subsequent metastasis. |
| eu_rights_str_mv | openAccess |
| format | masterThesis |
| id | LAURepo_16fb0741ac600838b7a644ba2feb829f |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/13685 |
| publishDate | 2021 |
| publisher.none.fl_str_mv | Lebanese American University |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Palladin Regulates Invasion in Glioblastoma Multiforme Through Rho GTPasesFarran, MohammadGlioblastoma multiformeRho GTPasesCancer cellsLebanese American University -- DissertationsDissertations, AcademicGlioblastoma multiforme (GBM), is one of the most fatal types of human cancers. GBM tumors exhibit significant heterogeneity and can arise through two distinct routes, forming what is known as primary glioblastoma and secondary glioblastoma. Palladin is a fairly recent protein that plays an important role in regulating actin and has been implicated in numerous cellular processes like adhesion, motility, invasion, and metastasis. Changes in palladin expression have also been observed in invasive tumors like breast and pancreatic cancer. In this study, we showed that palladin regulates the invasion of glioblastoma cells by affecting invadopodia formation. We also highlighted cross talks between palladin and Rho GTPases like Cdc42 and Rac1 that are also implicated in GBM invasion. This paper offers interesting insights into the role of palladin and Rho GTPases in the complex networks that drive the formation of invadopodia in glioblastoma multiforme, leading to invasion and subsequent metastasis.1 online resource (xiii, 42 leaves): ill. (some col.)Includes bibliographical references (leaf 36-42)Lebanese American University2022-06-15T09:20:38Z2022-06-15T09:20:38Z20212021-07-29Thesisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesishttp://hdl.handle.net/10725/13685https://doi.org/10.26756/th.2022.227http://libraries.lau.edu.lb/research/laur/terms-of-use/thesis.phpeninfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/136852024-02-15T12:07:18Z |
| spellingShingle | Palladin Regulates Invasion in Glioblastoma Multiforme Through Rho GTPases Farran, Mohammad Glioblastoma multiforme Rho GTPases Cancer cells Lebanese American University -- Dissertations Dissertations, Academic |
| status_str | publishedVersion |
| title | Palladin Regulates Invasion in Glioblastoma Multiforme Through Rho GTPases |
| title_full | Palladin Regulates Invasion in Glioblastoma Multiforme Through Rho GTPases |
| title_fullStr | Palladin Regulates Invasion in Glioblastoma Multiforme Through Rho GTPases |
| title_full_unstemmed | Palladin Regulates Invasion in Glioblastoma Multiforme Through Rho GTPases |
| title_short | Palladin Regulates Invasion in Glioblastoma Multiforme Through Rho GTPases |
| title_sort | Palladin Regulates Invasion in Glioblastoma Multiforme Through Rho GTPases |
| topic | Glioblastoma multiforme Rho GTPases Cancer cells Lebanese American University -- Dissertations Dissertations, Academic |
| url | http://hdl.handle.net/10725/13685 https://doi.org/10.26756/th.2022.227 http://libraries.lau.edu.lb/research/laur/terms-of-use/thesis.php |