A transfer function method for the continuous assessment of baroreflex control of renal sympathetic nerve activity in rats
The present study examined whether the gain of the transfer function relating cardiac-related rhythm of renal sympathetic nerve activity (RSNA) to arterial pressure (AP) pulse might serve as a spontaneous index of sympathetic baroreflex sensitivity (BRS). AP and RSNA were simultaneously recorded in...
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2007
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| Online Access: | http://hdl.handle.net/10725/4549 http://dx.doi.org/10.1152/ajpregu.00374.2007 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://ajpregu.physiology.org/content/293/5/R1938.short |
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| _version_ | 1864513463987994624 |
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| author | Kanbar, Roy |
| author2 | Orea, Valerie Chapuis, Bruno Barres, Christian Julien, Claude |
| author2_role | author author author author |
| author_facet | Kanbar, Roy Orea, Valerie Chapuis, Bruno Barres, Christian Julien, Claude |
| author_role | author |
| dc.creator.none.fl_str_mv | Kanbar, Roy Orea, Valerie Chapuis, Bruno Barres, Christian Julien, Claude |
| dc.date.none.fl_str_mv | 2007 2016-10-10T11:15:31Z 2016-10-10T11:15:31Z 2016-10-10 |
| dc.identifier.none.fl_str_mv | 0363-6119 http://hdl.handle.net/10725/4549 http://dx.doi.org/10.1152/ajpregu.00374.2007 Kanbar, R., Oréa, V., Chapuis, B., Barres, C., & Julien, C. (2007). A transfer function method for the continuous assessment of baroreflex control of renal sympathetic nerve activity in rats. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 293(5), R1938-R1946. http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://ajpregu.physiology.org/content/293/5/R1938.short |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | American Journal of Physiology |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | A transfer function method for the continuous assessment of baroreflex control of renal sympathetic nerve activity in rats |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | The present study examined whether the gain of the transfer function relating cardiac-related rhythm of renal sympathetic nerve activity (RSNA) to arterial pressure (AP) pulse might serve as a spontaneous index of sympathetic baroreflex sensitivity (BRS). AP and RSNA were simultaneously recorded in conscious rats, either baroreceptor-intact (control, n = 11) or with partial denervation of baroreflex afferents [aortic baroreceptor denervated (ABD; n = 10)] during 1-h periods of spontaneous activity. Transfer gain was calculated over 58 adjacent 61.4-s periods (segmented into 10.2-s periods). Coherence between AP and RSNA was statistically (P < 0.05) significant in 90 ± 3% and 56 ± 10% of cases in control and ABD rats, respectively. Transfer gain was higher (P = 0.0049) in control [2.39 ± 0.13 normalized units (NU)/mmHg] than in ABD (1.48 ± 0.22 NU/mmHg) rats. In the pooled study sample, transfer gain correlated with sympathetic BRS estimated by the vasoactive drug injection technique (R = 0.75; P < 0.0001) and was inversely related to both time- (standard deviation; R = −0.74; P = 0.0001) and frequency-domain [total spectral power (0.00028–2.5 Hz); R = −0.82; P < 0.0001] indices of AP variability. In control rats, transfer gain exhibited large fluctuations (coefficient of variation: 34 ± 3%) that were not consistently related to changes in the mean level of AP, heart rate, or RSNA. In conclusion, the transfer function method provides a continuous, functionally relevant index of sympathetic BRS and reveals that the latter fluctuates widely over time. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_178eaeb3ef5ed9a0cfbdf173f4a4506e |
| identifier_str_mv | 0363-6119 Kanbar, R., Oréa, V., Chapuis, B., Barres, C., & Julien, C. (2007). A transfer function method for the continuous assessment of baroreflex control of renal sympathetic nerve activity in rats. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 293(5), R1938-R1946. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/4549 |
| publishDate | 2007 |
| repository.mail.fl_str_mv | |
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| spelling | A transfer function method for the continuous assessment of baroreflex control of renal sympathetic nerve activity in ratsKanbar, RoyOrea, ValerieChapuis, BrunoBarres, ChristianJulien, ClaudeThe present study examined whether the gain of the transfer function relating cardiac-related rhythm of renal sympathetic nerve activity (RSNA) to arterial pressure (AP) pulse might serve as a spontaneous index of sympathetic baroreflex sensitivity (BRS). AP and RSNA were simultaneously recorded in conscious rats, either baroreceptor-intact (control, n = 11) or with partial denervation of baroreflex afferents [aortic baroreceptor denervated (ABD; n = 10)] during 1-h periods of spontaneous activity. Transfer gain was calculated over 58 adjacent 61.4-s periods (segmented into 10.2-s periods). Coherence between AP and RSNA was statistically (P < 0.05) significant in 90 ± 3% and 56 ± 10% of cases in control and ABD rats, respectively. Transfer gain was higher (P = 0.0049) in control [2.39 ± 0.13 normalized units (NU)/mmHg] than in ABD (1.48 ± 0.22 NU/mmHg) rats. In the pooled study sample, transfer gain correlated with sympathetic BRS estimated by the vasoactive drug injection technique (R = 0.75; P < 0.0001) and was inversely related to both time- (standard deviation; R = −0.74; P = 0.0001) and frequency-domain [total spectral power (0.00028–2.5 Hz); R = −0.82; P < 0.0001] indices of AP variability. In control rats, transfer gain exhibited large fluctuations (coefficient of variation: 34 ± 3%) that were not consistently related to changes in the mean level of AP, heart rate, or RSNA. In conclusion, the transfer function method provides a continuous, functionally relevant index of sympathetic BRS and reveals that the latter fluctuates widely over time.PublishedN/A2016-10-10T11:15:31Z2016-10-10T11:15:31Z20072016-10-10Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article0363-6119http://hdl.handle.net/10725/4549http://dx.doi.org/10.1152/ajpregu.00374.2007Kanbar, R., Oréa, V., Chapuis, B., Barres, C., & Julien, C. (2007). A transfer function method for the continuous assessment of baroreflex control of renal sympathetic nerve activity in rats. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 293(5), R1938-R1946.http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.phphttp://ajpregu.physiology.org/content/293/5/R1938.shortenAmerican Journal of Physiologyinfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/45492021-03-19T10:03:18Z |
| spellingShingle | A transfer function method for the continuous assessment of baroreflex control of renal sympathetic nerve activity in rats Kanbar, Roy |
| status_str | publishedVersion |
| title | A transfer function method for the continuous assessment of baroreflex control of renal sympathetic nerve activity in rats |
| title_full | A transfer function method for the continuous assessment of baroreflex control of renal sympathetic nerve activity in rats |
| title_fullStr | A transfer function method for the continuous assessment of baroreflex control of renal sympathetic nerve activity in rats |
| title_full_unstemmed | A transfer function method for the continuous assessment of baroreflex control of renal sympathetic nerve activity in rats |
| title_short | A transfer function method for the continuous assessment of baroreflex control of renal sympathetic nerve activity in rats |
| title_sort | A transfer function method for the continuous assessment of baroreflex control of renal sympathetic nerve activity in rats |
| url | http://hdl.handle.net/10725/4549 http://dx.doi.org/10.1152/ajpregu.00374.2007 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://ajpregu.physiology.org/content/293/5/R1938.short |