Effective treatment of hypereosinophilic syndrome with imatinib mesylate
Imatinib mesylate treatment is highly effective in chronic myeloid leukaemia and recent data have suggested that imatinib mesylate is also effective in the treatment of idiopathic hypereosinophilicsyndrome (HES). Six patients with HES were treated daily with 100 mg imatinib mesylate. Five patients h...
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| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , , , , , |
| التنسيق: | article |
| منشور في: |
2003
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| الوصول للمادة أونلاين: | http://hdl.handle.net/10725/11087 https://doi.org/10.1038/sj.thj.6200294 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://www.researchgate.net/profile/Beatrice_Chami/publication/8962207_Effective_treatment_of_hypereosinophilic_syndrome_with_imatinib_mesylate/links/545868ee0cf26d5090ab62a9.pdf |
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| _version_ | 1864513488248897536 |
|---|---|
| author | Salem, Ziad |
| author2 | Zalloua, Pierre A. Chehali, Aref Bitar, Nizar Abboud, Miguel kadri, Adel Chami, Beatrice Bazarbachi, Ali |
| author2_role | author author author author author author author |
| author_facet | Salem, Ziad Zalloua, Pierre A. Chehali, Aref Bitar, Nizar Abboud, Miguel kadri, Adel Chami, Beatrice Bazarbachi, Ali |
| author_role | author |
| dc.creator.none.fl_str_mv | Salem, Ziad Zalloua, Pierre A. Chehali, Aref Bitar, Nizar Abboud, Miguel kadri, Adel Chami, Beatrice Bazarbachi, Ali |
| dc.date.none.fl_str_mv | 2003 2019-07-19T06:38:17Z 2019-07-19T06:38:17Z 2019-07-19 |
| dc.identifier.none.fl_str_mv | 1466-4860 http://hdl.handle.net/10725/11087 https://doi.org/10.1038/sj.thj.6200294 Salem, Z., Zalloua, P. A., Chehal, A., Bitar, N., Abboud, M., Kadri, A., ... & Bazarbachi, A. (2003). Effective treatment of hypereosinophilic syndrome with imatinib mesylate. The Hematology Journal, 4(6), 410-412. http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://www.researchgate.net/profile/Beatrice_Chami/publication/8962207_Effective_treatment_of_hypereosinophilic_syndrome_with_imatinib_mesylate/links/545868ee0cf26d5090ab62a9.pdf |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | The Hematology Journal |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | Effective treatment of hypereosinophilic syndrome with imatinib mesylate |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Imatinib mesylate treatment is highly effective in chronic myeloid leukaemia and recent data have suggested that imatinib mesylate is also effective in the treatment of idiopathic hypereosinophilicsyndrome (HES). Six patients with HES were treated daily with 100 mg imatinib mesylate. Five patients had normal karyotype and one showed trisomy 8. RT-PCR was negative for ETV6-PDGFRB and BCR-ABL fusion mRNAs. All patients rapidly achieved complete haematological remission. One patient remained in remission for more than 6 weeks after discontinuing treatment. No significant side effect was noted. Imatinib mesylate should be considered in the first-line therapy of idiopathic HES. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_18c756df8457c12dfd72476884c94496 |
| identifier_str_mv | 1466-4860 Salem, Z., Zalloua, P. A., Chehal, A., Bitar, N., Abboud, M., Kadri, A., ... & Bazarbachi, A. (2003). Effective treatment of hypereosinophilic syndrome with imatinib mesylate. The Hematology Journal, 4(6), 410-412. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/11087 |
| publishDate | 2003 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Effective treatment of hypereosinophilic syndrome with imatinib mesylateSalem, ZiadZalloua, Pierre A.Chehali, ArefBitar, NizarAbboud, Miguelkadri, AdelChami, BeatriceBazarbachi, AliImatinib mesylate treatment is highly effective in chronic myeloid leukaemia and recent data have suggested that imatinib mesylate is also effective in the treatment of idiopathic hypereosinophilicsyndrome (HES). Six patients with HES were treated daily with 100 mg imatinib mesylate. Five patients had normal karyotype and one showed trisomy 8. RT-PCR was negative for ETV6-PDGFRB and BCR-ABL fusion mRNAs. All patients rapidly achieved complete haematological remission. One patient remained in remission for more than 6 weeks after discontinuing treatment. No significant side effect was noted. Imatinib mesylate should be considered in the first-line therapy of idiopathic HES.PublishedN/A2019-07-19T06:38:17Z2019-07-19T06:38:17Z20032019-07-19Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1466-4860http://hdl.handle.net/10725/11087https://doi.org/10.1038/sj.thj.6200294Salem, Z., Zalloua, P. A., Chehal, A., Bitar, N., Abboud, M., Kadri, A., ... & Bazarbachi, A. (2003). Effective treatment of hypereosinophilic syndrome with imatinib mesylate. The Hematology Journal, 4(6), 410-412.http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.phphttps://www.researchgate.net/profile/Beatrice_Chami/publication/8962207_Effective_treatment_of_hypereosinophilic_syndrome_with_imatinib_mesylate/links/545868ee0cf26d5090ab62a9.pdfenThe Hematology Journalinfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/110872021-03-19T10:47:35Z |
| spellingShingle | Effective treatment of hypereosinophilic syndrome with imatinib mesylate Salem, Ziad |
| status_str | publishedVersion |
| title | Effective treatment of hypereosinophilic syndrome with imatinib mesylate |
| title_full | Effective treatment of hypereosinophilic syndrome with imatinib mesylate |
| title_fullStr | Effective treatment of hypereosinophilic syndrome with imatinib mesylate |
| title_full_unstemmed | Effective treatment of hypereosinophilic syndrome with imatinib mesylate |
| title_short | Effective treatment of hypereosinophilic syndrome with imatinib mesylate |
| title_sort | Effective treatment of hypereosinophilic syndrome with imatinib mesylate |
| url | http://hdl.handle.net/10725/11087 https://doi.org/10.1038/sj.thj.6200294 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://www.researchgate.net/profile/Beatrice_Chami/publication/8962207_Effective_treatment_of_hypereosinophilic_syndrome_with_imatinib_mesylate/links/545868ee0cf26d5090ab62a9.pdf |