Long-term survival after surgical management of neuroendocrine hepatic metastases
Background: Surgical cytoreduction and endocrine blockade are important options for care for neuroendocrine liver metastases. We investigated the long-term survival of patients surgically treated for hepatic neuroendocrine metastases. Methods: Patients (n= 172) undergoing operations for neuroendoc...
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2010
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| Online Access: | http://hdl.handle.net/10725/2615 http://dx.doi.org/10.1111/j.1477-2574.2010.00198.x |
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| _version_ | 1864513458726240256 |
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| author | Glazer, Evan |
| author2 | Tseng, Jennifer Al-Refaie, Waddah Solorzano, Carmen Liu, Ping Willborn, Katherine Abdalla, Eddie Vauthey, Jean-Nicolas |
| author2_role | author author author author author author author |
| author_facet | Glazer, Evan Tseng, Jennifer Al-Refaie, Waddah Solorzano, Carmen Liu, Ping Willborn, Katherine Abdalla, Eddie Vauthey, Jean-Nicolas |
| author_role | author |
| dc.creator.none.fl_str_mv | Glazer, Evan Tseng, Jennifer Al-Refaie, Waddah Solorzano, Carmen Liu, Ping Willborn, Katherine Abdalla, Eddie Vauthey, Jean-Nicolas |
| dc.date.none.fl_str_mv | 2010 2015-11-19T08:09:23Z 2015-11-19T08:09:23Z 2015-11-19 |
| dc.identifier.none.fl_str_mv | 1365-182X http://hdl.handle.net/10725/2615 http://dx.doi.org/10.1111/j.1477-2574.2010.00198.x Glazer, E. S., Tseng, J. F., Al‐Refaie, W., Solorzano, C. C., Liu, P., Willborn, K. A., ... & Curley, S. A. (2010). Long‐term survival after surgical management of neuroendocrine hepatic metastases. Hpb, 12(6), 427-433. |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | HBP |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | Long-term survival after surgical management of neuroendocrine hepatic metastases |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Background: Surgical cytoreduction and endocrine blockade are important options for care for neuroendocrine liver metastases. We investigated the long-term survival of patients surgically treated for hepatic neuroendocrine metastases. Methods: Patients (n= 172) undergoing operations for neuroendocrine liver metastases from any primary were identified from a prospective liver database. Recorded data and medical record review were used to analyse the type of procedure, length of hospital stay, peri-operative morbidity, tumour recurrence, progression,and survival. Results: The median age was 56.8 years (range 11.5–80.7 years). 48.3% of patients were female. Median overall survival was 9.6 years (range 89 days to 22 years). On multivariate analysis, lung/thymic primaries were associated with worse survival [hazard ratio (HR): 15.6, confidence interval (CI): 4.3–56.8, P= 0.002]. Severe post-operative complications were also associated with worse long-term survival (P < 0.001). A positive resection margin status (R1) was not associated with a worse overall survival probability (P∼ 0.8). Discussion: Early and aggressive surgical management of hepatic metastases from neuroendocrine tumours is associated with significant long-term survival rates. Radiofrequency ablation is a reasonable option if a lesion is unresectable. R1 resections, unlike many other cancers, are not associated with a worse overall survival. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_1bc0010ca0548a02a683657b6feeb0c6 |
| identifier_str_mv | 1365-182X Glazer, E. S., Tseng, J. F., Al‐Refaie, W., Solorzano, C. C., Liu, P., Willborn, K. A., ... & Curley, S. A. (2010). Long‐term survival after surgical management of neuroendocrine hepatic metastases. Hpb, 12(6), 427-433. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/2615 |
| publishDate | 2010 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Long-term survival after surgical management of neuroendocrine hepatic metastasesGlazer, EvanTseng, JenniferAl-Refaie, WaddahSolorzano, CarmenLiu, PingWillborn, KatherineAbdalla, EddieVauthey, Jean-NicolasBackground: Surgical cytoreduction and endocrine blockade are important options for care for neuroendocrine liver metastases. We investigated the long-term survival of patients surgically treated for hepatic neuroendocrine metastases. Methods: Patients (n= 172) undergoing operations for neuroendocrine liver metastases from any primary were identified from a prospective liver database. Recorded data and medical record review were used to analyse the type of procedure, length of hospital stay, peri-operative morbidity, tumour recurrence, progression,and survival. Results: The median age was 56.8 years (range 11.5–80.7 years). 48.3% of patients were female. Median overall survival was 9.6 years (range 89 days to 22 years). On multivariate analysis, lung/thymic primaries were associated with worse survival [hazard ratio (HR): 15.6, confidence interval (CI): 4.3–56.8, P= 0.002]. Severe post-operative complications were also associated with worse long-term survival (P < 0.001). A positive resection margin status (R1) was not associated with a worse overall survival probability (P∼ 0.8). Discussion: Early and aggressive surgical management of hepatic metastases from neuroendocrine tumours is associated with significant long-term survival rates. Radiofrequency ablation is a reasonable option if a lesion is unresectable. R1 resections, unlike many other cancers, are not associated with a worse overall survival.PublishedN/A2015-11-19T08:09:23Z2015-11-19T08:09:23Z20102015-11-19Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1365-182Xhttp://hdl.handle.net/10725/2615http://dx.doi.org/10.1111/j.1477-2574.2010.00198.xGlazer, E. S., Tseng, J. F., Al‐Refaie, W., Solorzano, C. C., Liu, P., Willborn, K. A., ... & Curley, S. A. (2010). Long‐term survival after surgical management of neuroendocrine hepatic metastases. Hpb, 12(6), 427-433.enHBPinfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/26152019-02-26T10:17:32Z |
| spellingShingle | Long-term survival after surgical management of neuroendocrine hepatic metastases Glazer, Evan |
| status_str | publishedVersion |
| title | Long-term survival after surgical management of neuroendocrine hepatic metastases |
| title_full | Long-term survival after surgical management of neuroendocrine hepatic metastases |
| title_fullStr | Long-term survival after surgical management of neuroendocrine hepatic metastases |
| title_full_unstemmed | Long-term survival after surgical management of neuroendocrine hepatic metastases |
| title_short | Long-term survival after surgical management of neuroendocrine hepatic metastases |
| title_sort | Long-term survival after surgical management of neuroendocrine hepatic metastases |
| url | http://hdl.handle.net/10725/2615 http://dx.doi.org/10.1111/j.1477-2574.2010.00198.x |