A long-lived cuprous bis-phenanthroline complex for the photodynamic therapy of cancer
Copper is an earth-abundant and a biologically essential metal that offers a promising alternative to noble metals in photochemistry and photobiology. In this work, a series of sterically encumbered Cu(I) bis-phenanthroline complexes were investigated for their use in photochemotherapy (PCT). It was...
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2018
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| Online Access: | http://hdl.handle.net/10725/7805 http://dx.doi.org/10.1039/c8dt00140e http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://pubs.rsc.org/en/content/articlehtml/2018/dt/c8dt00140e |
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| _version_ | 1864513467056128000 |
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| author | Al Hageh, Cynthia |
| author2 | Al Assaad, Majd El Masri, Zeinab Samaan, Nawar El-Sibai, Mirvat Khalil, Christian Khnayzer, Rony S. |
| author2_role | author author author author author author |
| author_facet | Al Hageh, Cynthia Al Assaad, Majd El Masri, Zeinab Samaan, Nawar El-Sibai, Mirvat Khalil, Christian Khnayzer, Rony S. |
| author_role | author |
| dc.creator.none.fl_str_mv | Al Hageh, Cynthia Al Assaad, Majd El Masri, Zeinab Samaan, Nawar El-Sibai, Mirvat Khalil, Christian Khnayzer, Rony S. |
| dc.date.none.fl_str_mv | 2018-05-11T11:06:57Z 2018-05-11T11:06:57Z 2018 2018-05-11 |
| dc.identifier.none.fl_str_mv | 1477-9234 http://hdl.handle.net/10725/7805 http://dx.doi.org/10.1039/c8dt00140e Al Hageh, C., Al Assaad, M., El Masri, Z., Samaan, N., El-Sibai, M., Khalil, C., & Khnayzer, R. S. (2018). A long-lived cuprous bis-phenanthroline complex for the photodynamic therapy of cancer. Dalton Transactions, 47(14), 4959-4967. http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://pubs.rsc.org/en/content/articlehtml/2018/dt/c8dt00140e |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | Dalton Transactions |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | A long-lived cuprous bis-phenanthroline complex for the photodynamic therapy of cancer |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Copper is an earth-abundant and a biologically essential metal that offers a promising alternative to noble metals in photochemistry and photobiology. In this work, a series of sterically encumbered Cu(I) bis-phenanthroline complexes were investigated for their use in photochemotherapy (PCT). It was found that Cu(dsbtmp)2+ [dsbtmp = 2,9-disec-butyl-3,4,7,8-tetramethyl-1,10-phenanthroline] (compound 3), which possessed the longest excited state lifetime, exhibited significant in vitro photocytotoxicity on A375 (human malignant melanoma) and A549 (human lung carcinoma) cell lines. Fluorescence imaging demonstrated the significant uptake and localization of compound 3 in a perinuclear fashion. A comet assay indicated the induction of DNA damage in the dark. The DNA breaks were significantly amplified upon photoactivation. The light-induced enhancement of cytotoxicity was associated with the formation of reactive oxygen species (ROS), a known intermediate in photodynamic therapy (PDT). This successful demonstration of photocytotoxicity using long-lived cuprous phenanthroline paves the way to exploit this class of photosensitizers for PDT applications. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_1f1e0acc172c3dc305d56fdcbe2aba43 |
| identifier_str_mv | 1477-9234 Al Hageh, C., Al Assaad, M., El Masri, Z., Samaan, N., El-Sibai, M., Khalil, C., & Khnayzer, R. S. (2018). A long-lived cuprous bis-phenanthroline complex for the photodynamic therapy of cancer. Dalton Transactions, 47(14), 4959-4967. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/7805 |
| publishDate | 2018 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | A long-lived cuprous bis-phenanthroline complex for the photodynamic therapy of cancerAl Hageh, CynthiaAl Assaad, MajdEl Masri, ZeinabSamaan, NawarEl-Sibai, MirvatKhalil, ChristianKhnayzer, Rony S.Copper is an earth-abundant and a biologically essential metal that offers a promising alternative to noble metals in photochemistry and photobiology. In this work, a series of sterically encumbered Cu(I) bis-phenanthroline complexes were investigated for their use in photochemotherapy (PCT). It was found that Cu(dsbtmp)2+ [dsbtmp = 2,9-disec-butyl-3,4,7,8-tetramethyl-1,10-phenanthroline] (compound 3), which possessed the longest excited state lifetime, exhibited significant in vitro photocytotoxicity on A375 (human malignant melanoma) and A549 (human lung carcinoma) cell lines. Fluorescence imaging demonstrated the significant uptake and localization of compound 3 in a perinuclear fashion. A comet assay indicated the induction of DNA damage in the dark. The DNA breaks were significantly amplified upon photoactivation. The light-induced enhancement of cytotoxicity was associated with the formation of reactive oxygen species (ROS), a known intermediate in photodynamic therapy (PDT). This successful demonstration of photocytotoxicity using long-lived cuprous phenanthroline paves the way to exploit this class of photosensitizers for PDT applications.PublishedN/A2018-05-11T11:06:57Z2018-05-11T11:06:57Z20182018-05-11Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1477-9234http://hdl.handle.net/10725/7805http://dx.doi.org/10.1039/c8dt00140eAl Hageh, C., Al Assaad, M., El Masri, Z., Samaan, N., El-Sibai, M., Khalil, C., & Khnayzer, R. S. (2018). A long-lived cuprous bis-phenanthroline complex for the photodynamic therapy of cancer. Dalton Transactions, 47(14), 4959-4967.http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.phphttp://pubs.rsc.org/en/content/articlehtml/2018/dt/c8dt00140eenDalton Transactionsinfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/78052021-03-19T10:03:30Z |
| spellingShingle | A long-lived cuprous bis-phenanthroline complex for the photodynamic therapy of cancer Al Hageh, Cynthia |
| status_str | publishedVersion |
| title | A long-lived cuprous bis-phenanthroline complex for the photodynamic therapy of cancer |
| title_full | A long-lived cuprous bis-phenanthroline complex for the photodynamic therapy of cancer |
| title_fullStr | A long-lived cuprous bis-phenanthroline complex for the photodynamic therapy of cancer |
| title_full_unstemmed | A long-lived cuprous bis-phenanthroline complex for the photodynamic therapy of cancer |
| title_short | A long-lived cuprous bis-phenanthroline complex for the photodynamic therapy of cancer |
| title_sort | A long-lived cuprous bis-phenanthroline complex for the photodynamic therapy of cancer |
| url | http://hdl.handle.net/10725/7805 http://dx.doi.org/10.1039/c8dt00140e http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://pubs.rsc.org/en/content/articlehtml/2018/dt/c8dt00140e |