Human recombinant arginase I (Co)-PEG5000 [HuArgI (Co)-PEG5000]-induced arginine depletion is selectively cytotoxic to human glioblastoma cells
In this study, we attempt to target Arginine auxotrophy in glioblastoma multiforme (GBM) cells using a pegylated recombinant human Arginase I cobalt [HuArgI (Co)-PEG5000]. We tested and characterized the activity of HuArgI (Co)-PEG5000 on a panel of 9 GBM cell lines and on human fetal glial cells (S...
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| Other Authors: | , , , , |
| Format: | article |
| Published: |
2015
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| Online Access: | http://hdl.handle.net/10725/2739 http://dx.doi.org/10.1007/s11060-014-1698-5 http://link.springer.com/article/10.1007/s11060-014-1698-5 |
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