Cafeteria diet-fed mice is a pertinent model of obesity-induced organ damage
Objective This study is aimed at evaluating the effects of a cafeteria diet (obesity) mouse model on early multi-organ functional, structural, endocrine and biochemical alterations. Materials and methods Multi-organ damage is assessed using clinical, biochemical, pathological, and inflammatory param...
محفوظ في:
| المؤلف الرئيسي: | |
|---|---|
| مؤلفون آخرون: | , , |
| التنسيق: | article |
| منشور في: |
2015
|
| الوصول للمادة أونلاين: | http://hdl.handle.net/10725/5290 http://dx.doi.org/10.1007/s00011-015-0831-z http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://link.springer.com/article/10.1007/s00011-015-0831-z |
| الوسوم: |
إضافة وسم
لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!
|
| _version_ | 1864513465782108160 |
|---|---|
| author | Zeeni, Nadine |
| author2 | Dimassi, Hani Faour, Wissam H. Dagher-Hamalian, Carole |
| author2_role | author author author |
| author_facet | Zeeni, Nadine Dimassi, Hani Faour, Wissam H. Dagher-Hamalian, Carole |
| author_role | author |
| dc.creator.none.fl_str_mv | Zeeni, Nadine Dimassi, Hani Faour, Wissam H. Dagher-Hamalian, Carole |
| dc.date.none.fl_str_mv | 2015 2017-02-28T14:08:59Z 2017-02-28T14:08:59Z 2017-02-28 |
| dc.identifier.none.fl_str_mv | 1023-3830 http://hdl.handle.net/10725/5290 http://dx.doi.org/10.1007/s00011-015-0831-z Zeeni, N., Dagher-Hamalian, C., Dimassi, H., & Faour, W. H. (2015). Cafeteria diet-fed mice is a pertinent model of obesity-induced organ damage: a potential role of inflammation. Inflammation Research, 64(7), 501-512. http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://link.springer.com/article/10.1007/s00011-015-0831-z |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | Inflammation Research |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | Cafeteria diet-fed mice is a pertinent model of obesity-induced organ damage a potential role of inflammation |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Objective This study is aimed at evaluating the effects of a cafeteria diet (obesity) mouse model on early multi-organ functional, structural, endocrine and biochemical alterations. Materials and methods Multi-organ damage is assessed using clinical, biochemical, pathological, and inflammatory parameters in 30 mice fed one of the three diets for 15 weeks: standard chow diet (SC), high fat (HF), or “Cafeteria diet” (CAF) (standard SC and a choice of highly palatable human cafeteria foods: chocolate, biscuits, and peanut butter). Results CAF diet was associated with an increase in body weight, energy intake, and serum cholesterol levels compared to the other diets, as well as higher insulin levels and lower glucose tolerance. Additionally, consumption of the CAF diet was associated with significantly higher weight gain, abdominal fat, and serum IL-6 levels, as well as more damage in the heart (coronary perivascular fibrosis and steatosis), kidney (chronic interstitial inflammation and glomerular sclerosis), and liver (liver weight, portal fibrosis, apoptosis, and steatosis) compared to the HF diet. Conclusion Functional and structural damage in CAF were higher than HF of similar macronutrient composition. This study provides a novel dietary model in mice that mimics multi-organ physiologic alterations in humans secondary to obesity. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_2204fb24ded813232e1390af276ee8db |
| identifier_str_mv | 1023-3830 Zeeni, N., Dagher-Hamalian, C., Dimassi, H., & Faour, W. H. (2015). Cafeteria diet-fed mice is a pertinent model of obesity-induced organ damage: a potential role of inflammation. Inflammation Research, 64(7), 501-512. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/5290 |
| publishDate | 2015 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Cafeteria diet-fed mice is a pertinent model of obesity-induced organ damagea potential role of inflammationZeeni, NadineDimassi, HaniFaour, Wissam H.Dagher-Hamalian, CaroleObjective This study is aimed at evaluating the effects of a cafeteria diet (obesity) mouse model on early multi-organ functional, structural, endocrine and biochemical alterations. Materials and methods Multi-organ damage is assessed using clinical, biochemical, pathological, and inflammatory parameters in 30 mice fed one of the three diets for 15 weeks: standard chow diet (SC), high fat (HF), or “Cafeteria diet” (CAF) (standard SC and a choice of highly palatable human cafeteria foods: chocolate, biscuits, and peanut butter). Results CAF diet was associated with an increase in body weight, energy intake, and serum cholesterol levels compared to the other diets, as well as higher insulin levels and lower glucose tolerance. Additionally, consumption of the CAF diet was associated with significantly higher weight gain, abdominal fat, and serum IL-6 levels, as well as more damage in the heart (coronary perivascular fibrosis and steatosis), kidney (chronic interstitial inflammation and glomerular sclerosis), and liver (liver weight, portal fibrosis, apoptosis, and steatosis) compared to the HF diet. Conclusion Functional and structural damage in CAF were higher than HF of similar macronutrient composition. This study provides a novel dietary model in mice that mimics multi-organ physiologic alterations in humans secondary to obesity.PublishedN/A2017-02-28T14:08:59Z2017-02-28T14:08:59Z20152017-02-28Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1023-3830http://hdl.handle.net/10725/5290http://dx.doi.org/10.1007/s00011-015-0831-zZeeni, N., Dagher-Hamalian, C., Dimassi, H., & Faour, W. H. (2015). Cafeteria diet-fed mice is a pertinent model of obesity-induced organ damage: a potential role of inflammation. Inflammation Research, 64(7), 501-512.http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.phphttps://link.springer.com/article/10.1007/s00011-015-0831-zenInflammation Researchinfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/52902021-03-19T10:00:54Z |
| spellingShingle | Cafeteria diet-fed mice is a pertinent model of obesity-induced organ damage Zeeni, Nadine |
| status_str | publishedVersion |
| title | Cafeteria diet-fed mice is a pertinent model of obesity-induced organ damage |
| title_full | Cafeteria diet-fed mice is a pertinent model of obesity-induced organ damage |
| title_fullStr | Cafeteria diet-fed mice is a pertinent model of obesity-induced organ damage |
| title_full_unstemmed | Cafeteria diet-fed mice is a pertinent model of obesity-induced organ damage |
| title_short | Cafeteria diet-fed mice is a pertinent model of obesity-induced organ damage |
| title_sort | Cafeteria diet-fed mice is a pertinent model of obesity-induced organ damage |
| url | http://hdl.handle.net/10725/5290 http://dx.doi.org/10.1007/s00011-015-0831-z http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://link.springer.com/article/10.1007/s00011-015-0831-z |