Invadopodia, Regulation, and Assembly in Cancer Cell Invasion
The occurrence of invadopodia has been, since its characterization, a hallmark of cancerous cell invasion and metastasis. These structures are now the subject of a controversy concerning their cellular function, molecular regulation, and assembly. The terms invadopodia and podosomes have been used i...
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| Format: | article |
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2014
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| Online Access: | http://hdl.handle.net/10725/2845 http://dx.doi.org/10.3109/15419061.2014.923845 http://www.tandfonline.com/doi/abs/10.3109/15419061.2014.923845 |
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| _version_ | 1864513459445563392 |
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| author | Saykali, Bechara A. |
| author2 | El-Sibai, Mirvat |
| author2_role | author |
| author_facet | Saykali, Bechara A. El-Sibai, Mirvat |
| author_role | author |
| dc.creator.none.fl_str_mv | Saykali, Bechara A. El-Sibai, Mirvat |
| dc.date.none.fl_str_mv | 2014 2015-12-18T07:08:22Z 2015-12-18T07:08:22Z 2015-12-18 |
| dc.identifier.none.fl_str_mv | 1541-9061 http://hdl.handle.net/10725/2845 http://dx.doi.org/10.3109/15419061.2014.923845 Saykali, B. A., & El-Sibai, M. (2014). Invadopodia, regulation, and assembly in cancer cell invasion. Cell communication & adhesion, 21(4), 207-212. http://www.tandfonline.com/doi/abs/10.3109/15419061.2014.923845 |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | Cell Communication & Adhesion |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | Invadopodia, Regulation, and Assembly in Cancer Cell Invasion |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | The occurrence of invadopodia has been, since its characterization, a hallmark of cancerous cell invasion and metastasis. These structures are now the subject of a controversy concerning their cellular function, molecular regulation, and assembly. The terms invadopodia and podosomes have been used interchangeably since their discovery back in 1980. Since then, these phenotypes are now more established and accepted by the scientific community as vital structures for 3D cancer cell motility. Many characteristics relating to invadopodia and podosomes have been elucidated, which might prove these structures as good targets for metastasis treatment. In this review, we briefly review the actin reorganization process needed in most types of cancer cell motility. We also review the important characteristics of invadopodia, including molecular components, assembly, markers, and the signaling pathways, providing a comprehensive model for invadopodia regulation. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_22a1ea9cc42a8e89505bbeca98dd6b4a |
| identifier_str_mv | 1541-9061 Saykali, B. A., & El-Sibai, M. (2014). Invadopodia, regulation, and assembly in cancer cell invasion. Cell communication & adhesion, 21(4), 207-212. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/2845 |
| publishDate | 2014 |
| repository.mail.fl_str_mv | |
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| spelling | Invadopodia, Regulation, and Assembly in Cancer Cell InvasionSaykali, Bechara A.El-Sibai, MirvatThe occurrence of invadopodia has been, since its characterization, a hallmark of cancerous cell invasion and metastasis. These structures are now the subject of a controversy concerning their cellular function, molecular regulation, and assembly. The terms invadopodia and podosomes have been used interchangeably since their discovery back in 1980. Since then, these phenotypes are now more established and accepted by the scientific community as vital structures for 3D cancer cell motility. Many characteristics relating to invadopodia and podosomes have been elucidated, which might prove these structures as good targets for metastasis treatment. In this review, we briefly review the actin reorganization process needed in most types of cancer cell motility. We also review the important characteristics of invadopodia, including molecular components, assembly, markers, and the signaling pathways, providing a comprehensive model for invadopodia regulation.PublishedN/A2015-12-18T07:08:22Z2015-12-18T07:08:22Z20142015-12-18Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1541-9061http://hdl.handle.net/10725/2845http://dx.doi.org/10.3109/15419061.2014.923845Saykali, B. A., & El-Sibai, M. (2014). Invadopodia, regulation, and assembly in cancer cell invasion. Cell communication & adhesion, 21(4), 207-212.http://www.tandfonline.com/doi/abs/10.3109/15419061.2014.923845enCell Communication & Adhesioninfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/28452026-02-19T07:33:45Z |
| spellingShingle | Invadopodia, Regulation, and Assembly in Cancer Cell Invasion Saykali, Bechara A. |
| status_str | publishedVersion |
| title | Invadopodia, Regulation, and Assembly in Cancer Cell Invasion |
| title_full | Invadopodia, Regulation, and Assembly in Cancer Cell Invasion |
| title_fullStr | Invadopodia, Regulation, and Assembly in Cancer Cell Invasion |
| title_full_unstemmed | Invadopodia, Regulation, and Assembly in Cancer Cell Invasion |
| title_short | Invadopodia, Regulation, and Assembly in Cancer Cell Invasion |
| title_sort | Invadopodia, Regulation, and Assembly in Cancer Cell Invasion |
| url | http://hdl.handle.net/10725/2845 http://dx.doi.org/10.3109/15419061.2014.923845 http://www.tandfonline.com/doi/abs/10.3109/15419061.2014.923845 |