Longitudinal Study of Hypertensive Subjects With Type 2 Diabetes Mellitus
Despite adequate glycemic and blood pressure control, treated type 2 diabetic hypertensive subjects have a significantly elevated overall/cardiovascular risk. We studied 244 816 normotensive and 99 720 hypertensive subjects (including 7480 type 2 diabetics) attending medical checkups between 1992 an...
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| مؤلفون آخرون: | , , , |
| التنسيق: | article |
| منشور في: |
2017
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| الوصول للمادة أونلاين: | http://hdl.handle.net/10725/10068 http://dx.doi.org/10.1161/HYPERTENSIONAHA.116.08962 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://www.ahajournals.org/doi/pdf/10.1161/HYPERTENSIONAHA.116.08962 |
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| _version_ | 1864513485806764032 |
|---|---|
| author | Bahous, Sola Aoun |
| author2 | Safar, Michel E. Gnakaméné, Jean-Barthélémy Yannoutsos, Alexandra Thomas, Frédérique |
| author2_role | author author author author |
| author_facet | Bahous, Sola Aoun Safar, Michel E. Gnakaméné, Jean-Barthélémy Yannoutsos, Alexandra Thomas, Frédérique |
| author_role | author |
| dc.creator.none.fl_str_mv | Bahous, Sola Aoun Safar, Michel E. Gnakaméné, Jean-Barthélémy Yannoutsos, Alexandra Thomas, Frédérique |
| dc.date.none.fl_str_mv | 2017 2019-02-22T11:25:00Z 2019-02-22T11:25:00Z 2019-02-22 |
| dc.identifier.none.fl_str_mv | 0194-911X http://hdl.handle.net/10725/10068 http://dx.doi.org/10.1161/HYPERTENSIONAHA.116.08962 Safar, M. E., Gnakaméné, J. B., Bahous, S. A., Yannoutsos, A., & Thomas, F. (2017). Longitudinal study of hypertensive subjects with type 2 diabetes mellitus: overall and cardiovascular risk. Hypertension, 69(6), 1029-1035. http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://www.ahajournals.org/doi/pdf/10.1161/HYPERTENSIONAHA.116.08962 |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | Hypertension |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | Longitudinal Study of Hypertensive Subjects With Type 2 Diabetes Mellitus |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Despite adequate glycemic and blood pressure control, treated type 2 diabetic hypertensive subjects have a significantly elevated overall/cardiovascular risk. We studied 244 816 normotensive and 99 720 hypertensive subjects (including 7480 type 2 diabetics) attending medical checkups between 1992 and 2011. We sought to identify significant differences in overall/cardiovascular risk between hypertension with and without diabetes mellitus. Mean follow-up was 12.7 years; 14 050 all-cause deaths were reported. From normotensive to hypertensive populations, a significant progression in overall/cardiovascular mortality was observed. Mortality was significantly greater among diabetic than nondiabetic hypertensive subjects (all-cause mortality, 14.05% versus 7.43%; and cardiovascular mortality, 1.28% versus 0.7%). No interaction was observed between hemodynamic measurements and overall/cardiovascular risk, suggesting that blood pressure factors, even during drug therapy, could not explain the differences in mortality rates between diabetic and nondiabetic hypertensive patients. Using cross-sectional regression models, a significant association was observed between higher education levels, lower levels of anxiety and depression, and reduced overall mortality in diabetic hypertensive subjects, while impaired renal function, a history of stroke and myocardial infarction, and increased alcohol and tobacco consumption were significantly associated with increased mortality. Blood pressure and glycemic control alone cannot reverse overall/cardiovascular risk in diabetics with hypertension. Together with cardiovascular measures, overall prevention should include recommendations to reduce alcohol and tobacco consumption and improve stress, education levels, and physical activity. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_242acd4fcbc6036e441981f29fcd5ea8 |
| identifier_str_mv | 0194-911X Safar, M. E., Gnakaméné, J. B., Bahous, S. A., Yannoutsos, A., & Thomas, F. (2017). Longitudinal study of hypertensive subjects with type 2 diabetes mellitus: overall and cardiovascular risk. Hypertension, 69(6), 1029-1035. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/10068 |
| publishDate | 2017 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Longitudinal Study of Hypertensive Subjects With Type 2 Diabetes MellitusBahous, Sola AounSafar, Michel E.Gnakaméné, Jean-BarthélémyYannoutsos, AlexandraThomas, FrédériqueDespite adequate glycemic and blood pressure control, treated type 2 diabetic hypertensive subjects have a significantly elevated overall/cardiovascular risk. We studied 244 816 normotensive and 99 720 hypertensive subjects (including 7480 type 2 diabetics) attending medical checkups between 1992 and 2011. We sought to identify significant differences in overall/cardiovascular risk between hypertension with and without diabetes mellitus. Mean follow-up was 12.7 years; 14 050 all-cause deaths were reported. From normotensive to hypertensive populations, a significant progression in overall/cardiovascular mortality was observed. Mortality was significantly greater among diabetic than nondiabetic hypertensive subjects (all-cause mortality, 14.05% versus 7.43%; and cardiovascular mortality, 1.28% versus 0.7%). No interaction was observed between hemodynamic measurements and overall/cardiovascular risk, suggesting that blood pressure factors, even during drug therapy, could not explain the differences in mortality rates between diabetic and nondiabetic hypertensive patients. Using cross-sectional regression models, a significant association was observed between higher education levels, lower levels of anxiety and depression, and reduced overall mortality in diabetic hypertensive subjects, while impaired renal function, a history of stroke and myocardial infarction, and increased alcohol and tobacco consumption were significantly associated with increased mortality. Blood pressure and glycemic control alone cannot reverse overall/cardiovascular risk in diabetics with hypertension. Together with cardiovascular measures, overall prevention should include recommendations to reduce alcohol and tobacco consumption and improve stress, education levels, and physical activity.PublishedN/A2019-02-22T11:25:00Z2019-02-22T11:25:00Z20172019-02-22Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article0194-911Xhttp://hdl.handle.net/10725/10068http://dx.doi.org/10.1161/HYPERTENSIONAHA.116.08962Safar, M. E., Gnakaméné, J. B., Bahous, S. A., Yannoutsos, A., & Thomas, F. (2017). Longitudinal study of hypertensive subjects with type 2 diabetes mellitus: overall and cardiovascular risk. Hypertension, 69(6), 1029-1035.http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.phphttps://www.ahajournals.org/doi/pdf/10.1161/HYPERTENSIONAHA.116.08962enHypertensioninfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/100682021-03-19T10:45:28Z |
| spellingShingle | Longitudinal Study of Hypertensive Subjects With Type 2 Diabetes Mellitus Bahous, Sola Aoun |
| status_str | publishedVersion |
| title | Longitudinal Study of Hypertensive Subjects With Type 2 Diabetes Mellitus |
| title_full | Longitudinal Study of Hypertensive Subjects With Type 2 Diabetes Mellitus |
| title_fullStr | Longitudinal Study of Hypertensive Subjects With Type 2 Diabetes Mellitus |
| title_full_unstemmed | Longitudinal Study of Hypertensive Subjects With Type 2 Diabetes Mellitus |
| title_short | Longitudinal Study of Hypertensive Subjects With Type 2 Diabetes Mellitus |
| title_sort | Longitudinal Study of Hypertensive Subjects With Type 2 Diabetes Mellitus |
| url | http://hdl.handle.net/10725/10068 http://dx.doi.org/10.1161/HYPERTENSIONAHA.116.08962 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://www.ahajournals.org/doi/pdf/10.1161/HYPERTENSIONAHA.116.08962 |