Potent neurotoxic fluorinated 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine analogs as potential probes in models of parkinson disease
We synthesized a number of fluorinated analogs of 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP), and tested their suitability as substrates for monoamine oxidase B in vitro and their dopaminergic neurotoxicity in vivo. Two of the compounds tested, 2′‐F‐MPTP and 2′‐CF3‐MPTP, were better enzyme...
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1988
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| Online Access: | http://hdl.handle.net/10725/10435 https://doi.org/10.1111/j.1471-4159.1988.tb10610.x http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1471-4159.1988.tb10610.x |
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