Genome Analysis of Streptococcus pyogenes Associated with Pharyngitis and Skin Infections
Streptococcus pyogenes is a very important human pathogen, commonly associated with skin or throat infections but can also cause life-threatening situations including sepsis, streptococcal toxic shock syndrome, and necrotizing fasciitis. Various studies involving typing and molecular characterizatio...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , , , |
| التنسيق: | article |
| منشور في: |
2016
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| الوصول للمادة أونلاين: | http://hdl.handle.net/10725/5544 https://doi.org/10.1371/journal.pone.0168177 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0168177 |
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| _version_ | 1864513477343707136 |
|---|---|
| author | Khazen, Georges |
| author2 | Tokajian, Sima Ibrahim, Joe Eisen, Jonathan A. Jospin, Guillaume Coil, David A. |
| author2_role | author author author author author |
| author_facet | Khazen, Georges Tokajian, Sima Ibrahim, Joe Eisen, Jonathan A. Jospin, Guillaume Coil, David A. |
| author_role | author |
| dc.creator.none.fl_str_mv | Khazen, Georges Tokajian, Sima Ibrahim, Joe Eisen, Jonathan A. Jospin, Guillaume Coil, David A. |
| dc.date.none.fl_str_mv | 2016 2017-04-25T08:15:42Z 2017-04-25T08:15:42Z 2017-04-11 |
| dc.identifier.none.fl_str_mv | 1932-6203 http://hdl.handle.net/10725/5544 https://doi.org/10.1371/journal.pone.0168177 Ibrahim, J., Eisen, J. A., Jospin, G., Coil, D. A., Khazen, G., & Tokajian, S. (2016). Genome Analysis of Streptococcus pyogenes Associated with Pharyngitis and Skin Infections. PloS one, 11(12), e0168177. http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0168177 |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | PLOS One |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | Genome Analysis of Streptococcus pyogenes Associated with Pharyngitis and Skin Infections |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Streptococcus pyogenes is a very important human pathogen, commonly associated with skin or throat infections but can also cause life-threatening situations including sepsis, streptococcal toxic shock syndrome, and necrotizing fasciitis. Various studies involving typing and molecular characterization of S. pyogenes have been published to date; however next-generation sequencing (NGS) studies provide a comprehensive collection of an organism’s genetic variation. In this study, the genomes of nine S. pyogenes isolates associated with pharyngitis and skin infection were sequenced and studied for the presence of virulence genes, resistance elements, prophages, genomic recombination, and other genomic features. Additionally, a comparative phylogenetic analysis of the isolates with global clones highlighted their possible evolutionary lineage and their site of infection. The genomes were found to also house a multitude of features including gene regulation systems, virulence factors and antimicrobial resistance mechanisms. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_29936820ea653d56274acb2bbbfe111e |
| identifier_str_mv | 1932-6203 Ibrahim, J., Eisen, J. A., Jospin, G., Coil, D. A., Khazen, G., & Tokajian, S. (2016). Genome Analysis of Streptococcus pyogenes Associated with Pharyngitis and Skin Infections. PloS one, 11(12), e0168177. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/5544 |
| publishDate | 2016 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Genome Analysis of Streptococcus pyogenes Associated with Pharyngitis and Skin InfectionsKhazen, GeorgesTokajian, SimaIbrahim, JoeEisen, Jonathan A.Jospin, GuillaumeCoil, David A.Streptococcus pyogenes is a very important human pathogen, commonly associated with skin or throat infections but can also cause life-threatening situations including sepsis, streptococcal toxic shock syndrome, and necrotizing fasciitis. Various studies involving typing and molecular characterization of S. pyogenes have been published to date; however next-generation sequencing (NGS) studies provide a comprehensive collection of an organism’s genetic variation. In this study, the genomes of nine S. pyogenes isolates associated with pharyngitis and skin infection were sequenced and studied for the presence of virulence genes, resistance elements, prophages, genomic recombination, and other genomic features. Additionally, a comparative phylogenetic analysis of the isolates with global clones highlighted their possible evolutionary lineage and their site of infection. The genomes were found to also house a multitude of features including gene regulation systems, virulence factors and antimicrobial resistance mechanisms.PublishedN/A2017-04-25T08:15:42Z2017-04-25T08:15:42Z20162017-04-11Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1932-6203http://hdl.handle.net/10725/5544https://doi.org/10.1371/journal.pone.0168177Ibrahim, J., Eisen, J. A., Jospin, G., Coil, D. A., Khazen, G., & Tokajian, S. (2016). Genome Analysis of Streptococcus pyogenes Associated with Pharyngitis and Skin Infections. PloS one, 11(12), e0168177.http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.phphttp://journals.plos.org/plosone/article?id=10.1371/journal.pone.0168177enPLOS Oneinfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/55442021-03-19T10:00:54Z |
| spellingShingle | Genome Analysis of Streptococcus pyogenes Associated with Pharyngitis and Skin Infections Khazen, Georges |
| status_str | publishedVersion |
| title | Genome Analysis of Streptococcus pyogenes Associated with Pharyngitis and Skin Infections |
| title_full | Genome Analysis of Streptococcus pyogenes Associated with Pharyngitis and Skin Infections |
| title_fullStr | Genome Analysis of Streptococcus pyogenes Associated with Pharyngitis and Skin Infections |
| title_full_unstemmed | Genome Analysis of Streptococcus pyogenes Associated with Pharyngitis and Skin Infections |
| title_short | Genome Analysis of Streptococcus pyogenes Associated with Pharyngitis and Skin Infections |
| title_sort | Genome Analysis of Streptococcus pyogenes Associated with Pharyngitis and Skin Infections |
| url | http://hdl.handle.net/10725/5544 https://doi.org/10.1371/journal.pone.0168177 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0168177 |