Mining breast cancer genetic data

Analyzing breast cancer gene expression data is a very challenging problem due to the large amount of genes examined. Computational techniques have proved reliable to make sense of large amounts of data like the data obtained from microarray analysis. In this study, we present a method to find a clu...

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Bibliographic Details
Main Author: Mansour, Nashat (author)
Other Authors: Zantout, Rouba (author), El-Sibai, Mirvat (author)
Format: conferenceObject
Published: 2013
Online Access:http://hdl.handle.net/10725/7806
http://dx.doi.org/ 10.1109/ICNC.2013.6818131
http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php
https://ieeexplore.ieee.org/abstract/document/6818131/
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Summary:Analyzing breast cancer gene expression data is a very challenging problem due to the large amount of genes examined. Computational techniques have proved reliable to make sense of large amounts of data like the data obtained from microarray analysis. In this study, we present a method to find a clustering pattern of the genes involved in breast cancer. We design a growing hierarchical self-organizing map (GHSOM) to mine gene microarray data. We have applied GHSOM to 24,481 genes of DNA microarray of breast tumor samples. Our results have revealed 17 genes that are likely to be correlated with four breast cancer marker genes.