Effects of exendin-4 and selenium on the expression of GLP-1R, IRS-1, and preproinsulin in the pancreas of diabetic rats
The mechanisms by which exendin-4 and selenium exert their antidiabetic actions are still unclear. Here, we investigated the effects of exendin-4 or selenium administration on the expression of glucagon-like peptide-1 receptor (GLP-1R), insulin receptor substrate-1 (IRS-1), and preproinsulin in the...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , , , |
| التنسيق: | article |
| منشور في: |
2017
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| الوصول للمادة أونلاين: | http://hdl.handle.net/10725/8077 https://doi.org/10.1007/s13105-017-0565-1 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://link.springer.com/article/10.1007/s13105-017-0565-1 |
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| _version_ | 1864513483841732608 |
|---|---|
| author | Barakat, Ghinwa |
| author2 | Moustafa, Mohamed E. Khalifeh, Ibrahim Hodroj, Mohammad H. Bikhazi, Anwar Rizk, Sandra |
| author2_role | author author author author author |
| author_facet | Barakat, Ghinwa Moustafa, Mohamed E. Khalifeh, Ibrahim Hodroj, Mohammad H. Bikhazi, Anwar Rizk, Sandra |
| author_role | author |
| dc.creator.none.fl_str_mv | Barakat, Ghinwa Moustafa, Mohamed E. Khalifeh, Ibrahim Hodroj, Mohammad H. Bikhazi, Anwar Rizk, Sandra |
| dc.date.none.fl_str_mv | 2017 2018-06-21T10:21:57Z 2018-06-21T10:21:57Z 2018-06-21 |
| dc.identifier.none.fl_str_mv | 1138-7548 http://hdl.handle.net/10725/8077 https://doi.org/10.1007/s13105-017-0565-1 Barakat, G., Moustafa, M. E., Khalifeh, I., Hodroj, M. H., Bikhazi, A., & Rizk, S. (2017). Effects of exendin-4 and selenium on the expression of GLP-1R, IRS-1, and preproinsulin in the pancreas of diabetic rats. Journal of physiology and biochemistry, 73(3), 387-394. http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://link.springer.com/article/10.1007/s13105-017-0565-1 |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | Journal of Physiology and Biochemistry |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | Effects of exendin-4 and selenium on the expression of GLP-1R, IRS-1, and preproinsulin in the pancreas of diabetic rats |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | The mechanisms by which exendin-4 and selenium exert their antidiabetic actions are still unclear. Here, we investigated the effects of exendin-4 or selenium administration on the expression of glucagon-like peptide-1 receptor (GLP-1R), insulin receptor substrate-1 (IRS-1), and preproinsulin in the pancreas of diabetic rats. Diabetes was induced by streptozotocin administration. Diabetic rats were injected intraperitoneally with 0.03 μg exendin-4/kg body weight/daily or treated with 5 ppm selenium in drinking water for a period of 4 weeks. GLP-1R and IRS-1 levels were decreased while the level of preproinsulin messenger RNA (mRNA) was increased in the pancreas of diabetic untreated rats, as compared to that in control rats. Treatment of diabetic rats with exendin-4 increased protein and mRNA levels of GLP-1R, and IRS-1, and the mRNA level of preproinsulin in the pancreas, as compared to their levels in diabetic untreated rats. Selenium treatment of diabetic rats increased the pancreatic mRNA levels of GLP-1R, IRS-1, and preproinsulin. Exendin-4 or selenium treatment of diabetic rats also increased the numbers of pancreatic islets and GLP-1R molecules in the pancreas. Therefore, exendin-4 and selenium may exert their antidiabetic effects by increasing GLP-1R, IRS-1, and preproinsulin expression in the pancreas and by increasing the number of pancreatic islets. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_2aa8179527a2b7874f9cfdf42eddbd48 |
| identifier_str_mv | 1138-7548 Barakat, G., Moustafa, M. E., Khalifeh, I., Hodroj, M. H., Bikhazi, A., & Rizk, S. (2017). Effects of exendin-4 and selenium on the expression of GLP-1R, IRS-1, and preproinsulin in the pancreas of diabetic rats. Journal of physiology and biochemistry, 73(3), 387-394. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/8077 |
| publishDate | 2017 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Effects of exendin-4 and selenium on the expression of GLP-1R, IRS-1, and preproinsulin in the pancreas of diabetic ratsBarakat, GhinwaMoustafa, Mohamed E.Khalifeh, IbrahimHodroj, Mohammad H.Bikhazi, AnwarRizk, SandraThe mechanisms by which exendin-4 and selenium exert their antidiabetic actions are still unclear. Here, we investigated the effects of exendin-4 or selenium administration on the expression of glucagon-like peptide-1 receptor (GLP-1R), insulin receptor substrate-1 (IRS-1), and preproinsulin in the pancreas of diabetic rats. Diabetes was induced by streptozotocin administration. Diabetic rats were injected intraperitoneally with 0.03 μg exendin-4/kg body weight/daily or treated with 5 ppm selenium in drinking water for a period of 4 weeks. GLP-1R and IRS-1 levels were decreased while the level of preproinsulin messenger RNA (mRNA) was increased in the pancreas of diabetic untreated rats, as compared to that in control rats. Treatment of diabetic rats with exendin-4 increased protein and mRNA levels of GLP-1R, and IRS-1, and the mRNA level of preproinsulin in the pancreas, as compared to their levels in diabetic untreated rats. Selenium treatment of diabetic rats increased the pancreatic mRNA levels of GLP-1R, IRS-1, and preproinsulin. Exendin-4 or selenium treatment of diabetic rats also increased the numbers of pancreatic islets and GLP-1R molecules in the pancreas. Therefore, exendin-4 and selenium may exert their antidiabetic effects by increasing GLP-1R, IRS-1, and preproinsulin expression in the pancreas and by increasing the number of pancreatic islets.PublishedN/A2018-06-21T10:21:57Z2018-06-21T10:21:57Z20172018-06-21Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1138-7548http://hdl.handle.net/10725/8077https://doi.org/10.1007/s13105-017-0565-1Barakat, G., Moustafa, M. E., Khalifeh, I., Hodroj, M. H., Bikhazi, A., & Rizk, S. (2017). Effects of exendin-4 and selenium on the expression of GLP-1R, IRS-1, and preproinsulin in the pancreas of diabetic rats. Journal of physiology and biochemistry, 73(3), 387-394.http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.phphttps://link.springer.com/article/10.1007/s13105-017-0565-1enJournal of Physiology and Biochemistryinfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/80772021-03-19T10:43:14Z |
| spellingShingle | Effects of exendin-4 and selenium on the expression of GLP-1R, IRS-1, and preproinsulin in the pancreas of diabetic rats Barakat, Ghinwa |
| status_str | publishedVersion |
| title | Effects of exendin-4 and selenium on the expression of GLP-1R, IRS-1, and preproinsulin in the pancreas of diabetic rats |
| title_full | Effects of exendin-4 and selenium on the expression of GLP-1R, IRS-1, and preproinsulin in the pancreas of diabetic rats |
| title_fullStr | Effects of exendin-4 and selenium on the expression of GLP-1R, IRS-1, and preproinsulin in the pancreas of diabetic rats |
| title_full_unstemmed | Effects of exendin-4 and selenium on the expression of GLP-1R, IRS-1, and preproinsulin in the pancreas of diabetic rats |
| title_short | Effects of exendin-4 and selenium on the expression of GLP-1R, IRS-1, and preproinsulin in the pancreas of diabetic rats |
| title_sort | Effects of exendin-4 and selenium on the expression of GLP-1R, IRS-1, and preproinsulin in the pancreas of diabetic rats |
| url | http://hdl.handle.net/10725/8077 https://doi.org/10.1007/s13105-017-0565-1 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://link.springer.com/article/10.1007/s13105-017-0565-1 |