The Vitamin E Derivative Gamma Tocotrienol Promotes Anti-Tumor Effects in Acute Myeloid Leukemia Cell Lines
Acute myeloid leukemia (AML) is a blood cancer characterized by the formation of faulty defective myelogenous cells with morphological heterogeneity and cytogenic aberrations leading to a loss of their function. In an attempt to find an effective and safe AML treatment, vitamin E derivatives, includ...
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| مؤلفون آخرون: | , , , , , , |
| التنسيق: | article |
| منشور في: |
2019
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| الوصول للمادة أونلاين: | http://hdl.handle.net/10725/12029 https://doi.org/10.3390/nu11112808 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://www.mdpi.com/2072-6643/11/11/2808/htm |
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| _version_ | 1864513489695932416 |
|---|---|
| author | Ghanem, Paola |
| author2 | Zouein, Annalise Mohamad, Maya Hodroj, Mohammad H. Haykal, Tony Najem, Sonia Abou Naim, Hassan Y. Rizk, Sandra |
| author2_role | author author author author author author author |
| author_facet | Ghanem, Paola Zouein, Annalise Mohamad, Maya Hodroj, Mohammad H. Haykal, Tony Najem, Sonia Abou Naim, Hassan Y. Rizk, Sandra |
| author_role | author |
| dc.creator.none.fl_str_mv | Ghanem, Paola Zouein, Annalise Mohamad, Maya Hodroj, Mohammad H. Haykal, Tony Najem, Sonia Abou Naim, Hassan Y. Rizk, Sandra |
| dc.date.none.fl_str_mv | 2019 2020-07-24T11:21:42Z 2020-07-24T11:21:42Z 2020-07-24 |
| dc.identifier.none.fl_str_mv | 2072-6643 http://hdl.handle.net/10725/12029 https://doi.org/10.3390/nu11112808 Ghanem, P., Zouein, A., Mohamad, M., Hodroj, M. H., Haykal, T., Abou Najem, S., ... & Rizk, S. (2019). The Vitamin E Derivative Gamma Tocotrienol Promotes Anti-Tumor Effects in Acute Myeloid Leukemia Cell Lines. Nutrients, 11(11), 2808. http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://www.mdpi.com/2072-6643/11/11/2808/htm |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | Nutrients |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | The Vitamin E Derivative Gamma Tocotrienol Promotes Anti-Tumor Effects in Acute Myeloid Leukemia Cell Lines |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Acute myeloid leukemia (AML) is a blood cancer characterized by the formation of faulty defective myelogenous cells with morphological heterogeneity and cytogenic aberrations leading to a loss of their function. In an attempt to find an effective and safe AML treatment, vitamin E derivatives, including tocopherols were considered as potential anti-tumor compounds. Recently, other isoforms of vitamin E, namely tocotrienols have been proposed as potential potent anti-cancerous agents, displaying promising therapeutic effects in different cancer types. In this study we evaluated the anti-cancerous effects of γ-tocotrienol, on AML cell lines in vitro. For this purpose, AML cell lines incubated with γ-tocotrienol were examined for their viability, cell cycle status, apoptotic cell death, DNA fragmentation, production of reactive oxygen species and expression of proapoptotic proteins. Our results showed that γ-tocotrienol exhibits time and dose-dependent anti-proliferative, pro-apoptotic and antioxidant effects on U937 and KG-1 cell lines, through the upregulation of proteins involved in the intrinsic apoptotic pathway. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_2d1bf47b74f3e823ce39feea67a4ec45 |
| identifier_str_mv | 2072-6643 Ghanem, P., Zouein, A., Mohamad, M., Hodroj, M. H., Haykal, T., Abou Najem, S., ... & Rizk, S. (2019). The Vitamin E Derivative Gamma Tocotrienol Promotes Anti-Tumor Effects in Acute Myeloid Leukemia Cell Lines. Nutrients, 11(11), 2808. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/12029 |
| publishDate | 2019 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | The Vitamin E Derivative Gamma Tocotrienol Promotes Anti-Tumor Effects in Acute Myeloid Leukemia Cell LinesGhanem, PaolaZouein, AnnaliseMohamad, MayaHodroj, Mohammad H.Haykal, TonyNajem, Sonia AbouNaim, Hassan Y.Rizk, SandraAcute myeloid leukemia (AML) is a blood cancer characterized by the formation of faulty defective myelogenous cells with morphological heterogeneity and cytogenic aberrations leading to a loss of their function. In an attempt to find an effective and safe AML treatment, vitamin E derivatives, including tocopherols were considered as potential anti-tumor compounds. Recently, other isoforms of vitamin E, namely tocotrienols have been proposed as potential potent anti-cancerous agents, displaying promising therapeutic effects in different cancer types. In this study we evaluated the anti-cancerous effects of γ-tocotrienol, on AML cell lines in vitro. For this purpose, AML cell lines incubated with γ-tocotrienol were examined for their viability, cell cycle status, apoptotic cell death, DNA fragmentation, production of reactive oxygen species and expression of proapoptotic proteins. Our results showed that γ-tocotrienol exhibits time and dose-dependent anti-proliferative, pro-apoptotic and antioxidant effects on U937 and KG-1 cell lines, through the upregulation of proteins involved in the intrinsic apoptotic pathway.PublishedN/A2020-07-24T11:21:42Z2020-07-24T11:21:42Z20192020-07-24Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2072-6643http://hdl.handle.net/10725/12029https://doi.org/10.3390/nu11112808Ghanem, P., Zouein, A., Mohamad, M., Hodroj, M. H., Haykal, T., Abou Najem, S., ... & Rizk, S. (2019). The Vitamin E Derivative Gamma Tocotrienol Promotes Anti-Tumor Effects in Acute Myeloid Leukemia Cell Lines. Nutrients, 11(11), 2808.http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.phphttps://www.mdpi.com/2072-6643/11/11/2808/htmenNutrientsinfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/120292021-03-19T10:47:40Z |
| spellingShingle | The Vitamin E Derivative Gamma Tocotrienol Promotes Anti-Tumor Effects in Acute Myeloid Leukemia Cell Lines Ghanem, Paola |
| status_str | publishedVersion |
| title | The Vitamin E Derivative Gamma Tocotrienol Promotes Anti-Tumor Effects in Acute Myeloid Leukemia Cell Lines |
| title_full | The Vitamin E Derivative Gamma Tocotrienol Promotes Anti-Tumor Effects in Acute Myeloid Leukemia Cell Lines |
| title_fullStr | The Vitamin E Derivative Gamma Tocotrienol Promotes Anti-Tumor Effects in Acute Myeloid Leukemia Cell Lines |
| title_full_unstemmed | The Vitamin E Derivative Gamma Tocotrienol Promotes Anti-Tumor Effects in Acute Myeloid Leukemia Cell Lines |
| title_short | The Vitamin E Derivative Gamma Tocotrienol Promotes Anti-Tumor Effects in Acute Myeloid Leukemia Cell Lines |
| title_sort | The Vitamin E Derivative Gamma Tocotrienol Promotes Anti-Tumor Effects in Acute Myeloid Leukemia Cell Lines |
| url | http://hdl.handle.net/10725/12029 https://doi.org/10.3390/nu11112808 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://www.mdpi.com/2072-6643/11/11/2808/htm |