Prevalence of asthma, aspirin sensitivity and allergy in chronic rhinosinusitis: data from the UK National Chronic Rhinosinusitis Epidemiology Study
Background Chronic rhinosinusitis (CRS) is a common disorder associated with other respiratory tract diseases such as asthma and inhalant allergy. However, the prevalence of these co-morbidities varies considerably in the existing medical literature and by phenotype of CRS studied. The study objecti...
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| مؤلفون آخرون: | , , , , , |
| التنسيق: | article |
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2018
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| الوصول للمادة أونلاين: | http://hdl.handle.net/10725/17432 https://doi.org/10.1186/s12931-018-0823-y http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://link.springer.com/article/10.1186/s12931-018-0823-y |
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| _version_ | 1864513474449637376 |
|---|---|
| author | Philpott, Carl M. |
| author2 | Erskine, Sally Hopkins, Claire Kumar, Nirmal Anari, Shahram Kara, Naveed Salam, Mahmoud |
| author2_role | author author author author author author |
| author_facet | Philpott, Carl M. Erskine, Sally Hopkins, Claire Kumar, Nirmal Anari, Shahram Kara, Naveed Salam, Mahmoud |
| author_role | author |
| dc.creator.none.fl_str_mv | Philpott, Carl M. Erskine, Sally Hopkins, Claire Kumar, Nirmal Anari, Shahram Kara, Naveed Salam, Mahmoud |
| dc.date.none.fl_str_mv | 2018 2018 2025-10-29T14:12:57Z 2025-10-29T14:12:57Z |
| dc.identifier.none.fl_str_mv | 1465-9921 http://hdl.handle.net/10725/17432 https://doi.org/10.1186/s12931-018-0823-y Philpott, C. M., Erskine, S., Hopkins, C., Kumar, N., Anari, S., Kara, N., ... & Coombes, E. (2018). Prevalence of asthma, aspirin sensitivity and allergy in chronic rhinosinusitis: data from the UK National Chronic Rhinosinusitis Epidemiology Study. Respiratory research, 19(1), 129. http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://link.springer.com/article/10.1186/s12931-018-0823-y |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | Respiratory Research |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | Prevalence of asthma, aspirin sensitivity and allergy in chronic rhinosinusitis: data from the UK National Chronic Rhinosinusitis Epidemiology Study |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Background Chronic rhinosinusitis (CRS) is a common disorder associated with other respiratory tract diseases such as asthma and inhalant allergy. However, the prevalence of these co-morbidities varies considerably in the existing medical literature and by phenotype of CRS studied. The study objective was to identify the prevalence of asthma, inhalant allergy and aspirin sensitivity in CRS patients referred to secondary care and establish any differences between CRS phenotypes. Methods All participants were diagnosed in secondary care according to international guidelines and invited to complete a questionnaire including details of co-morbidities and allergies. Data were analysed for differences between controls and CRS participants and between phenotypes using chi-squared tests. Results The final analysis included 1470 study participants: 221 controls, 553 CRS without nasal polyps (CRSsNPs), 651 CRS with nasal polyps (CRSwNPs) and 45 allergic fungal rhinosinusitis (AFRS). The prevalence of asthma was 9.95, 21.16, 46.9 and 73.3% respectively. The prevalence of self-reported confirmed inhalant allergy was 13.1, 20.3, 31.0 and 33.3% respectively; house dust mite allergy was significantly higher in CRSwNPs (16%) compared to CRSsNPs (9%, p < 0.001). The prevalence of self- reported aspirin sensitivity was 2.26, 3.25, 9.61 and 40% respectively. The odds ratio for aspirin sensitivity amongst those with AFRS was 28.8 (CIs 9.9, 83.8) p < 0.001. Conclusions The prevalence of asthma and allergy in CRS varies by phenoytype, with CRSwNPs and AFRS having a stronger association with both. Aspirin sensitivity has a highly significant association with AFRS. All of these comorbidities are significantly more prevalent than in non-CRS controls and strengthen the need for a more individualised approach to the combined airway. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_2d4b5821da981c3bca9f4a891db2f3d2 |
| identifier_str_mv | 1465-9921 Philpott, C. M., Erskine, S., Hopkins, C., Kumar, N., Anari, S., Kara, N., ... & Coombes, E. (2018). Prevalence of asthma, aspirin sensitivity and allergy in chronic rhinosinusitis: data from the UK National Chronic Rhinosinusitis Epidemiology Study. Respiratory research, 19(1), 129. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/17432 |
| publishDate | 2018 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Prevalence of asthma, aspirin sensitivity and allergy in chronic rhinosinusitis: data from the UK National Chronic Rhinosinusitis Epidemiology StudyPhilpott, Carl M.Erskine, SallyHopkins, ClaireKumar, NirmalAnari, ShahramKara, NaveedSalam, MahmoudBackground Chronic rhinosinusitis (CRS) is a common disorder associated with other respiratory tract diseases such as asthma and inhalant allergy. However, the prevalence of these co-morbidities varies considerably in the existing medical literature and by phenotype of CRS studied. The study objective was to identify the prevalence of asthma, inhalant allergy and aspirin sensitivity in CRS patients referred to secondary care and establish any differences between CRS phenotypes. Methods All participants were diagnosed in secondary care according to international guidelines and invited to complete a questionnaire including details of co-morbidities and allergies. Data were analysed for differences between controls and CRS participants and between phenotypes using chi-squared tests. Results The final analysis included 1470 study participants: 221 controls, 553 CRS without nasal polyps (CRSsNPs), 651 CRS with nasal polyps (CRSwNPs) and 45 allergic fungal rhinosinusitis (AFRS). The prevalence of asthma was 9.95, 21.16, 46.9 and 73.3% respectively. The prevalence of self-reported confirmed inhalant allergy was 13.1, 20.3, 31.0 and 33.3% respectively; house dust mite allergy was significantly higher in CRSwNPs (16%) compared to CRSsNPs (9%, p < 0.001). The prevalence of self- reported aspirin sensitivity was 2.26, 3.25, 9.61 and 40% respectively. The odds ratio for aspirin sensitivity amongst those with AFRS was 28.8 (CIs 9.9, 83.8) p < 0.001. Conclusions The prevalence of asthma and allergy in CRS varies by phenoytype, with CRSwNPs and AFRS having a stronger association with both. Aspirin sensitivity has a highly significant association with AFRS. All of these comorbidities are significantly more prevalent than in non-CRS controls and strengthen the need for a more individualised approach to the combined airway.Published2025-10-29T14:12:57Z2025-10-29T14:12:57Z20182018Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1465-9921http://hdl.handle.net/10725/17432https://doi.org/10.1186/s12931-018-0823-yPhilpott, C. M., Erskine, S., Hopkins, C., Kumar, N., Anari, S., Kara, N., ... & Coombes, E. (2018). Prevalence of asthma, aspirin sensitivity and allergy in chronic rhinosinusitis: data from the UK National Chronic Rhinosinusitis Epidemiology Study. Respiratory research, 19(1), 129.http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.phphttps://link.springer.com/article/10.1186/s12931-018-0823-yenRespiratory Researchinfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/174322025-10-29T14:12:57Z |
| spellingShingle | Prevalence of asthma, aspirin sensitivity and allergy in chronic rhinosinusitis: data from the UK National Chronic Rhinosinusitis Epidemiology Study Philpott, Carl M. |
| status_str | publishedVersion |
| title | Prevalence of asthma, aspirin sensitivity and allergy in chronic rhinosinusitis: data from the UK National Chronic Rhinosinusitis Epidemiology Study |
| title_full | Prevalence of asthma, aspirin sensitivity and allergy in chronic rhinosinusitis: data from the UK National Chronic Rhinosinusitis Epidemiology Study |
| title_fullStr | Prevalence of asthma, aspirin sensitivity and allergy in chronic rhinosinusitis: data from the UK National Chronic Rhinosinusitis Epidemiology Study |
| title_full_unstemmed | Prevalence of asthma, aspirin sensitivity and allergy in chronic rhinosinusitis: data from the UK National Chronic Rhinosinusitis Epidemiology Study |
| title_short | Prevalence of asthma, aspirin sensitivity and allergy in chronic rhinosinusitis: data from the UK National Chronic Rhinosinusitis Epidemiology Study |
| title_sort | Prevalence of asthma, aspirin sensitivity and allergy in chronic rhinosinusitis: data from the UK National Chronic Rhinosinusitis Epidemiology Study |
| url | http://hdl.handle.net/10725/17432 https://doi.org/10.1186/s12931-018-0823-y http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://link.springer.com/article/10.1186/s12931-018-0823-y |