Valence tautomerism of singly protonated 9-aminoacridine and its implications for intercalative interactions with nucleic acids
Electronic absorption and fluorescence spectroscopy were used to show that the singly protonated 9-aminoacridine cation exists as the vinylogous cyclic amidine valence tautomer, the 9-iminoacridan monocation, in ground and excited states when in aqueous solution at physiological pH. The evidence ind...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , |
| التنسيق: | article |
| منشور في: |
1974
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| الوصول للمادة أونلاين: | http://hdl.handle.net/10725/6334 http://dx.doi.org/10.1002/jps.2600630823 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://onlinelibrary.wiley.com/doi/10.1002/jps.2600630823/full |
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| الملخص: | Electronic absorption and fluorescence spectroscopy were used to show that the singly protonated 9-aminoacridine cation exists as the vinylogous cyclic amidine valence tautomer, the 9-iminoacridan monocation, in ground and excited states when in aqueous solution at physiological pH. The evidence indicates that the 9-aminoacridine monocation may intercalate into double-helical DNA in an orientation different from that employed by other acridine derivatives. |
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