Distinctive roles of RhoA and RhoC in glioma cell motility, invasion, and invadopodia assembly. (c2018)
Malignant gliomas remain a medical concern in oncology due to their high morbidity rates and their aggressive behavior in the invasion of normal brain parenchyma. It has been a challenge to cure these types of brain tumors owing to the importance of the brain in regulating a plethora of human physio...
محفوظ في:
| المؤلف الرئيسي: | |
|---|---|
| التنسيق: | masterThesis |
| منشور في: |
2018
|
| الموضوعات: | |
| الوصول للمادة أونلاين: | http://hdl.handle.net/10725/8543 https://doi.org/10.26756/th.2018.72 http://libraries.lau.edu.lb/research/laur/terms-of-use/thesis.php |
| الوسوم: |
إضافة وسم
لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!
|
| _version_ | 1864513485038157824 |
|---|---|
| author | Dennaoui, Rayane |
| author_facet | Dennaoui, Rayane |
| author_role | author |
| dc.creator.none.fl_str_mv | Dennaoui, Rayane |
| dc.date.none.fl_str_mv | 2018-10-02T08:47:02Z 2018-10-02T08:47:02Z 2018 2018-10-02 2018-04-18 |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10725/8543 https://doi.org/10.26756/th.2018.72 http://libraries.lau.edu.lb/research/laur/terms-of-use/thesis.php |
| dc.language.none.fl_str_mv | en |
| dc.publisher.none.fl_str_mv | Lebanese American University |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Lebanese American University -- Dissertations Dissertations, Academic Cells -- Motility Microbial invasiveness Cell membranes -- Formation Astrocytomas GTPase-activating protein |
| dc.title.none.fl_str_mv | Distinctive roles of RhoA and RhoC in glioma cell motility, invasion, and invadopodia assembly. (c2018) |
| dc.type.none.fl_str_mv | Thesis info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/masterThesis |
| description | Malignant gliomas remain a medical concern in oncology due to their high morbidity rates and their aggressive behavior in the invasion of normal brain parenchyma. It has been a challenge to cure these types of brain tumors owing to the importance of the brain in regulating a plethora of human physiological functions, chemotherapy resistance, and inefficient surgical resection. Cell motility and invasion are patterns of glioma spreading and are multifaceted processes involving dynamic changes in the actin cytoskeleton. Major regulators that orchestrate actin reorganization and migration are members of the Rho family of GTPases. In this study, we investigate the contribution of two structurally similar Rho proteins, RhoA and RhoC, in glioma migration and invasion. One of our objectives was to explore the effects of both RhoA and RhoC on two- dimensional motility. Our data suggest that both proteins are positive regulators and enhancers of cell migration, adhesion to the extracellular matrix, and protrusion formation through the regulation of actin cytoskeletal dynamics. Another objective for the study was to study the differential roles of RhoA and RhoC in invasion and invadopodia assembly. We have found that RhoC is the main driver of the process in astrocytomas. In addition, we investigated possible cross-talks between RhoA, RhoC, Cdc42, and Rac1. Our data suggest that RhoA and RhoC downregulate both Rac1 and Cdc42 in order to achieve their roles in motility and invasion. |
| eu_rights_str_mv | openAccess |
| format | masterThesis |
| id | LAURepo_2ffd92deb896a87832eafc77aa8bb166 |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/8543 |
| publishDate | 2018 |
| publisher.none.fl_str_mv | Lebanese American University |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Distinctive roles of RhoA and RhoC in glioma cell motility, invasion, and invadopodia assembly. (c2018)Dennaoui, RayaneLebanese American University -- DissertationsDissertations, AcademicCells -- MotilityMicrobial invasivenessCell membranes -- FormationAstrocytomasGTPase-activating proteinMalignant gliomas remain a medical concern in oncology due to their high morbidity rates and their aggressive behavior in the invasion of normal brain parenchyma. It has been a challenge to cure these types of brain tumors owing to the importance of the brain in regulating a plethora of human physiological functions, chemotherapy resistance, and inefficient surgical resection. Cell motility and invasion are patterns of glioma spreading and are multifaceted processes involving dynamic changes in the actin cytoskeleton. Major regulators that orchestrate actin reorganization and migration are members of the Rho family of GTPases. In this study, we investigate the contribution of two structurally similar Rho proteins, RhoA and RhoC, in glioma migration and invasion. One of our objectives was to explore the effects of both RhoA and RhoC on two- dimensional motility. Our data suggest that both proteins are positive regulators and enhancers of cell migration, adhesion to the extracellular matrix, and protrusion formation through the regulation of actin cytoskeletal dynamics. Another objective for the study was to study the differential roles of RhoA and RhoC in invasion and invadopodia assembly. We have found that RhoC is the main driver of the process in astrocytomas. In addition, we investigated possible cross-talks between RhoA, RhoC, Cdc42, and Rac1. Our data suggest that RhoA and RhoC downregulate both Rac1 and Cdc42 in order to achieve their roles in motility and invasion.2020-04-181 hard copy: xvi, 70 leaves; col. ill.; 30 cm. available at RNL.Bibliography : leaves 59-70.Lebanese American University2018-10-02T08:47:02Z2018-10-02T08:47:02Z20182018-10-022018-04-18Thesisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesishttp://hdl.handle.net/10725/8543https://doi.org/10.26756/th.2018.72http://libraries.lau.edu.lb/research/laur/terms-of-use/thesis.phpeninfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/85432021-03-19T10:45:18Z |
| spellingShingle | Distinctive roles of RhoA and RhoC in glioma cell motility, invasion, and invadopodia assembly. (c2018) Dennaoui, Rayane Lebanese American University -- Dissertations Dissertations, Academic Cells -- Motility Microbial invasiveness Cell membranes -- Formation Astrocytomas GTPase-activating protein |
| status_str | publishedVersion |
| title | Distinctive roles of RhoA and RhoC in glioma cell motility, invasion, and invadopodia assembly. (c2018) |
| title_full | Distinctive roles of RhoA and RhoC in glioma cell motility, invasion, and invadopodia assembly. (c2018) |
| title_fullStr | Distinctive roles of RhoA and RhoC in glioma cell motility, invasion, and invadopodia assembly. (c2018) |
| title_full_unstemmed | Distinctive roles of RhoA and RhoC in glioma cell motility, invasion, and invadopodia assembly. (c2018) |
| title_short | Distinctive roles of RhoA and RhoC in glioma cell motility, invasion, and invadopodia assembly. (c2018) |
| title_sort | Distinctive roles of RhoA and RhoC in glioma cell motility, invasion, and invadopodia assembly. (c2018) |
| topic | Lebanese American University -- Dissertations Dissertations, Academic Cells -- Motility Microbial invasiveness Cell membranes -- Formation Astrocytomas GTPase-activating protein |
| url | http://hdl.handle.net/10725/8543 https://doi.org/10.26756/th.2018.72 http://libraries.lau.edu.lb/research/laur/terms-of-use/thesis.php |