Inhibition of Tau filament formation by conformational modulation
Antiaggregation drugs play an important role in therapeutic approaches for Alzheimer’s disease. Although a large number of small molecules that inhibit the aggregation of the tau protein have been identified, little is known about their mode of action. Here, we reveal the mechanism and the nature of...
محفوظ في:
| المؤلف الرئيسي: | Akoury, Elias (author) |
|---|---|
| مؤلفون آخرون: | Gajdat, Michal (author), Pickhardt, Marcus (author) |
| التنسيق: | article |
| منشور في: |
2013
|
| الوصول للمادة أونلاين: | http://hdl.handle.net/10725/10251 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://pubs.acs.org/doi/abs/10.1021/ja312471h |
| الوسوم: |
إضافة وسم
لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!
|
مواد مشابهة
-
Remodeling of the conformational ensemble of the repeat domain of tau by an aggregation enhancer
حسب: Akoury, Elias
منشور في: (2016) -
Molecular mechanisms of Tau protein aggregation inhibition
حسب: Akoury, Elias
منشور في: (2013) -
β-Sheet core of Tau paired helical filaments revealed by solid-state NMR
حسب: Akoury, Elias
منشور في: (2012) -
Mechanistic basis of phenothiazine‐driven inhibition of Tau aggregation
حسب: Akoury, Elias
منشور في: (2013) -
The active Hsc70/tau complex can be exploited to enhance tau turnover without damaging microtubule dynamics
حسب: Akoury, Elias
منشور في: (2015)