A urokinase-activated recombinant diphtheria toxin targeting the granulocyte-macrophage colony-stimulating factor receptor is selectively cytotoxic to human acute myeloid leukemia blasts
Novel agents to treat acute myeloid leukemia (AML) are needed with increased efficacy and specificity. We have synthesized a dual-specificity fusion toxin DTU2GMCSF composed of the catalytic and translocation domains of diphtheria toxin (DT) fused to the granulocyte-macrophage colony-stimulating fac...
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| Other Authors: | , , , |
| Format: | article |
| Published: |
2004
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| Online Access: | http://hdl.handle.net/10725/2732 http://dx.doi.org/10.1182/blood-2004-01-0339 http://www.bloodjournal.org/content/104/7/2143.full.pdf+html?sso-checked=true |
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