The STAR of the DLC family
RhoGTPases are defined as a family of 20 small G proteins playing important roles in almost every cellular process. RhoGTPases are guanine nucleotide-binding proteins existing in two forms: the active form which is GTP bound and the inactive one that being GDP bound. RhoGTPase-activating proteins kn...
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| Format: | article |
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2013
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| Online Access: | http://hdl.handle.net/10725/2824 http://dx.doi.org/10.3109/10799893.2012.752002 http://www.tandfonline.com/doi/abs/10.3109/10799893.2012.752002 |
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| _version_ | 1864513459437174784 |
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| author | El-Sitt, Sally |
| author2 | El-Sibai, Mirvat |
| author2_role | author |
| author_facet | El-Sitt, Sally El-Sibai, Mirvat |
| author_role | author |
| dc.creator.none.fl_str_mv | El-Sitt, Sally El-Sibai, Mirvat |
| dc.date.none.fl_str_mv | 2013 2015-12-17T13:10:53Z 2015-12-17T13:10:53Z 2015-12-17 |
| dc.identifier.none.fl_str_mv | 1079-9893 http://hdl.handle.net/10725/2824 http://dx.doi.org/10.3109/10799893.2012.752002 El-Sitt, S., & El-Sibai, M. (2013). The STAR of the DLC family. Journal of Receptors and Signal Transduction, 33(1), 10-13. http://www.tandfonline.com/doi/abs/10.3109/10799893.2012.752002 |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | Journal of Receptors and Signal Transduction |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | The STAR of the DLC family |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | RhoGTPases are defined as a family of 20 small G proteins playing important roles in almost every cellular process. RhoGTPases are guanine nucleotide-binding proteins existing in two forms: the active form which is GTP bound and the inactive one that being GDP bound. RhoGTPase-activating proteins known as RhoGAPs constitute one of the major classes of regulators of RhoGTPases. They act as negative regulators of the RhoGTPases by enhancing their slow intrinsic GTPase activity. STARD13, a GTPase activating protein (GAP) for RhoGTPases, has been described as a tumor suppressor in hepatocellular carcinoma. In the present review, we discuss the family of RhoGTPases, their regulation and their RhoGAPs, focusing mainly on STARD13. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_342c7d6ff313d743425ae7bdea08bc63 |
| identifier_str_mv | 1079-9893 El-Sitt, S., & El-Sibai, M. (2013). The STAR of the DLC family. Journal of Receptors and Signal Transduction, 33(1), 10-13. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/2824 |
| publishDate | 2013 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | The STAR of the DLC familyEl-Sitt, SallyEl-Sibai, MirvatRhoGTPases are defined as a family of 20 small G proteins playing important roles in almost every cellular process. RhoGTPases are guanine nucleotide-binding proteins existing in two forms: the active form which is GTP bound and the inactive one that being GDP bound. RhoGTPase-activating proteins known as RhoGAPs constitute one of the major classes of regulators of RhoGTPases. They act as negative regulators of the RhoGTPases by enhancing their slow intrinsic GTPase activity. STARD13, a GTPase activating protein (GAP) for RhoGTPases, has been described as a tumor suppressor in hepatocellular carcinoma. In the present review, we discuss the family of RhoGTPases, their regulation and their RhoGAPs, focusing mainly on STARD13.PublishedN/A2015-12-17T13:10:53Z2015-12-17T13:10:53Z20132015-12-17Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1079-9893http://hdl.handle.net/10725/2824http://dx.doi.org/10.3109/10799893.2012.752002El-Sitt, S., & El-Sibai, M. (2013). The STAR of the DLC family. Journal of Receptors and Signal Transduction, 33(1), 10-13.http://www.tandfonline.com/doi/abs/10.3109/10799893.2012.752002enJournal of Receptors and Signal Transductioninfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/28242020-05-11T19:58:08Z |
| spellingShingle | The STAR of the DLC family El-Sitt, Sally |
| status_str | publishedVersion |
| title | The STAR of the DLC family |
| title_full | The STAR of the DLC family |
| title_fullStr | The STAR of the DLC family |
| title_full_unstemmed | The STAR of the DLC family |
| title_short | The STAR of the DLC family |
| title_sort | The STAR of the DLC family |
| url | http://hdl.handle.net/10725/2824 http://dx.doi.org/10.3109/10799893.2012.752002 http://www.tandfonline.com/doi/abs/10.3109/10799893.2012.752002 |