ABCB1 (P-glycoprotein) and blood-brain barrier
ABCB1 (MDR1/P-glycoprotein) is an ATP-dependant transmenbrane protein widely expressed in human organs, protecting them against xenobiotics. ABCB1 is involved in drug pharmacokinetics: at the blood-brain barrier level, due to its luminal localisation, ABCB1 limits drug transport and plays an importa...
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| مؤلفون آخرون: | , |
| التنسيق: | article |
| منشور في: |
2006
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| الوصول للمادة أونلاين: | http://hdl.handle.net/10725/6846 http://dx.doi.org/10.1684/jpc.2006.0021 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://www.google.com.lb/search?q=ABCB+1+(P-glycoprotein)+and+blood-brain+barrier%3A+role+in+neurological+diseases+and+their+treatments&oq=ABCB+1+(P-glycoprotein)+and+blood-brain+barrier%3A+role+in+neurological+diseases+and+their+treatments&aqs=chrome..69i57j69i60l2.431j0j8&sourceid=chrome&ie=UTF-8 |
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| _version_ | 1864513481006383104 |
|---|---|
| author | Milane, Aline |
| author2 | Vautier, S. Fernandez, C. |
| author2_role | author author |
| author_facet | Milane, Aline Vautier, S. Fernandez, C. |
| author_role | author |
| dc.creator.none.fl_str_mv | Milane, Aline Vautier, S. Fernandez, C. |
| dc.date.none.fl_str_mv | 2006 2017-12-20T10:42:26Z 2017-12-20T10:42:26Z 2017-12-20 |
| dc.identifier.none.fl_str_mv | 1952-4064 http://hdl.handle.net/10725/6846 http://dx.doi.org/10.1684/jpc.2006.0021 Vautier, S., Fernandez, C., Milane, A., Lacomblez, L., Davrinche, C., & Farinotti, R. (2006). ABCB 1 (P-glycoprotein) and blood-brain barrier: role in neurological diseases and their treatments. JOURNAL DE PHARMACIE CLINIQUE, 25(4), 225. http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://www.google.com.lb/search?q=ABCB+1+(P-glycoprotein)+and+blood-brain+barrier%3A+role+in+neurological+diseases+and+their+treatments&oq=ABCB+1+(P-glycoprotein)+and+blood-brain+barrier%3A+role+in+neurological+diseases+and+their+treatments&aqs=chrome..69i57j69i60l2.431j0j8&sourceid=chrome&ie=UTF-8 |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | Journal de Pharmacie Clinique |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | ABCB1 (P-glycoprotein) and blood-brain barrier role in neurological diseases and their treatments |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | ABCB1 (MDR1/P-glycoprotein) is an ATP-dependant transmenbrane protein widely expressed in human organs, protecting them against xenobiotics. ABCB1 is involved in drug pharmacokinetics: at the blood-brain barrier level, due to its luminal localisation, ABCB1 limits drug transport and plays an important role in central detoxification. Many interindividual variabilities have been described on ABCB1 expression and functionality. Variabilities may play a role in the pathogenesis in neurological diseases. Furthermore, ABCB1 expression and/or functionality may modify drug efficacity or increase central adverse events. This paper reviews the implication of ABCB1 in the physiopathogenesis of neurological diseases and its role in the cerebral distribution of drugs. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_351fe56a08f93cbd0edcab059777b120 |
| identifier_str_mv | 1952-4064 Vautier, S., Fernandez, C., Milane, A., Lacomblez, L., Davrinche, C., & Farinotti, R. (2006). ABCB 1 (P-glycoprotein) and blood-brain barrier: role in neurological diseases and their treatments. JOURNAL DE PHARMACIE CLINIQUE, 25(4), 225. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/6846 |
| publishDate | 2006 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | ABCB1 (P-glycoprotein) and blood-brain barrierrole in neurological diseases and their treatmentsMilane, AlineVautier, S.Fernandez, C.ABCB1 (MDR1/P-glycoprotein) is an ATP-dependant transmenbrane protein widely expressed in human organs, protecting them against xenobiotics. ABCB1 is involved in drug pharmacokinetics: at the blood-brain barrier level, due to its luminal localisation, ABCB1 limits drug transport and plays an important role in central detoxification. Many interindividual variabilities have been described on ABCB1 expression and functionality. Variabilities may play a role in the pathogenesis in neurological diseases. Furthermore, ABCB1 expression and/or functionality may modify drug efficacity or increase central adverse events. This paper reviews the implication of ABCB1 in the physiopathogenesis of neurological diseases and its role in the cerebral distribution of drugs.PublishedN/A2017-12-20T10:42:26Z2017-12-20T10:42:26Z20062017-12-20Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1952-4064http://hdl.handle.net/10725/6846http://dx.doi.org/10.1684/jpc.2006.0021Vautier, S., Fernandez, C., Milane, A., Lacomblez, L., Davrinche, C., & Farinotti, R. (2006). ABCB 1 (P-glycoprotein) and blood-brain barrier: role in neurological diseases and their treatments. JOURNAL DE PHARMACIE CLINIQUE, 25(4), 225.http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.phphttps://www.google.com.lb/search?q=ABCB+1+(P-glycoprotein)+and+blood-brain+barrier%3A+role+in+neurological+diseases+and+their+treatments&oq=ABCB+1+(P-glycoprotein)+and+blood-brain+barrier%3A+role+in+neurological+diseases+and+their+treatments&aqs=chrome..69i57j69i60l2.431j0j8&sourceid=chrome&ie=UTF-8enJournal de Pharmacie Cliniqueinfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/68462021-03-19T10:43:11Z |
| spellingShingle | ABCB1 (P-glycoprotein) and blood-brain barrier Milane, Aline |
| status_str | publishedVersion |
| title | ABCB1 (P-glycoprotein) and blood-brain barrier |
| title_full | ABCB1 (P-glycoprotein) and blood-brain barrier |
| title_fullStr | ABCB1 (P-glycoprotein) and blood-brain barrier |
| title_full_unstemmed | ABCB1 (P-glycoprotein) and blood-brain barrier |
| title_short | ABCB1 (P-glycoprotein) and blood-brain barrier |
| title_sort | ABCB1 (P-glycoprotein) and blood-brain barrier |
| url | http://hdl.handle.net/10725/6846 http://dx.doi.org/10.1684/jpc.2006.0021 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://www.google.com.lb/search?q=ABCB+1+(P-glycoprotein)+and+blood-brain+barrier%3A+role+in+neurological+diseases+and+their+treatments&oq=ABCB+1+(P-glycoprotein)+and+blood-brain+barrier%3A+role+in+neurological+diseases+and+their+treatments&aqs=chrome..69i57j69i60l2.431j0j8&sourceid=chrome&ie=UTF-8 |