Impact of C-reactive protein test results on evidence-based decision-making in cases of bacterial infection
Background C-reactive protein (CRP) is widely used to detect bacterial infection in children. We investigated the impact of CRP test results on decision-making and summarized the evidence base (EB) of CRP testing. Methods We collected information from the hospital records of 91 neonates with suspect...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , |
| التنسيق: | article |
| منشور في: |
2012
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| الوصول للمادة أونلاين: | http://hdl.handle.net/10725/4768 http://dx.doi.org/10.1186/1471-2431-12-140 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://bmcpediatr.biomedcentral.com/articles/10.1186/1471-2431-12-140 |
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| _version_ | 1864513464569954304 |
|---|---|
| author | Nabulsi, Mona |
| author2 | Hani, Abeer Karam, Maria |
| author2_role | author author |
| author_facet | Nabulsi, Mona Hani, Abeer Karam, Maria |
| author_role | author |
| dc.creator.none.fl_str_mv | Nabulsi, Mona Hani, Abeer Karam, Maria |
| dc.date.none.fl_str_mv | 2012 2016-11-11T09:36:42Z 2016-11-11T09:36:42Z 2016-11-11 |
| dc.identifier.none.fl_str_mv | 1471-2431 http://hdl.handle.net/10725/4768 http://dx.doi.org/10.1186/1471-2431-12-140 Nabulsi, M., Hani, A., & Karam, M. (2012). Impact of C-reactive protein test results on evidence-based decision-making in cases of bacterial infection. BMC pediatrics, 12(1), 1-7 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://bmcpediatr.biomedcentral.com/articles/10.1186/1471-2431-12-140 |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | BMC Pediatrics |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | Impact of C-reactive protein test results on evidence-based decision-making in cases of bacterial infection |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Background C-reactive protein (CRP) is widely used to detect bacterial infection in children. We investigated the impact of CRP test results on decision-making and summarized the evidence base (EB) of CRP testing. Methods We collected information from the hospital records of 91 neonates with suspected sepsis and of 152 febrile children with suspected infection on the number of ordered CRP tests, the number of EB-CRP tests, and the impact of the test results on decision-making. CRP diagnostic accuracy studies focusing on pediatric infections were reviewed critically. The main outcomes were the proportion of CRP tests that were EB and the proportion of tests that affected decision-making. A secondary outcome was the overall one-year expenditure on CRP testing. Results The current EB for CRP testing in pediatric infections is weak and suggests that CRP is of low diagnostic value. Approximately 54.8% of tests performed for suspected neonatal sepsis and 28% of tests performed for other infections were EB; however, the results of only 12.9% of neonatal sepsis tests and of 29.9% of tests on children with other infections informed decision-making. The one-year overall cost for CRP testing and related health care was $26,715.9. Conclusions The routine ordering of CRP for children with infections is based on weak evidence. The impact of the CRP test results on decision-making is rather small, and CRP ordering may contribute to unnecessary health care expenditures. Better quality research is needed to definitively determine the diagnostic accuracy of CRP levels in children with infections. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_35a1e9da1eae2ebb654c022125cb0551 |
| identifier_str_mv | 1471-2431 Nabulsi, M., Hani, A., & Karam, M. (2012). Impact of C-reactive protein test results on evidence-based decision-making in cases of bacterial infection. BMC pediatrics, 12(1), 1-7 |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/4768 |
| publishDate | 2012 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Impact of C-reactive protein test results on evidence-based decision-making in cases of bacterial infectionNabulsi, MonaHani, AbeerKaram, MariaBackground C-reactive protein (CRP) is widely used to detect bacterial infection in children. We investigated the impact of CRP test results on decision-making and summarized the evidence base (EB) of CRP testing. Methods We collected information from the hospital records of 91 neonates with suspected sepsis and of 152 febrile children with suspected infection on the number of ordered CRP tests, the number of EB-CRP tests, and the impact of the test results on decision-making. CRP diagnostic accuracy studies focusing on pediatric infections were reviewed critically. The main outcomes were the proportion of CRP tests that were EB and the proportion of tests that affected decision-making. A secondary outcome was the overall one-year expenditure on CRP testing. Results The current EB for CRP testing in pediatric infections is weak and suggests that CRP is of low diagnostic value. Approximately 54.8% of tests performed for suspected neonatal sepsis and 28% of tests performed for other infections were EB; however, the results of only 12.9% of neonatal sepsis tests and of 29.9% of tests on children with other infections informed decision-making. The one-year overall cost for CRP testing and related health care was $26,715.9. Conclusions The routine ordering of CRP for children with infections is based on weak evidence. The impact of the CRP test results on decision-making is rather small, and CRP ordering may contribute to unnecessary health care expenditures. Better quality research is needed to definitively determine the diagnostic accuracy of CRP levels in children with infections.PublishedN/A2016-11-11T09:36:42Z2016-11-11T09:36:42Z20122016-11-11Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1471-2431http://hdl.handle.net/10725/4768http://dx.doi.org/10.1186/1471-2431-12-140Nabulsi, M., Hani, A., & Karam, M. (2012). Impact of C-reactive protein test results on evidence-based decision-making in cases of bacterial infection. BMC pediatrics, 12(1), 1-7http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.phphttps://bmcpediatr.biomedcentral.com/articles/10.1186/1471-2431-12-140enBMC Pediatricsinfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/47682022-06-30T09:55:30Z |
| spellingShingle | Impact of C-reactive protein test results on evidence-based decision-making in cases of bacterial infection Nabulsi, Mona |
| status_str | publishedVersion |
| title | Impact of C-reactive protein test results on evidence-based decision-making in cases of bacterial infection |
| title_full | Impact of C-reactive protein test results on evidence-based decision-making in cases of bacterial infection |
| title_fullStr | Impact of C-reactive protein test results on evidence-based decision-making in cases of bacterial infection |
| title_full_unstemmed | Impact of C-reactive protein test results on evidence-based decision-making in cases of bacterial infection |
| title_short | Impact of C-reactive protein test results on evidence-based decision-making in cases of bacterial infection |
| title_sort | Impact of C-reactive protein test results on evidence-based decision-making in cases of bacterial infection |
| url | http://hdl.handle.net/10725/4768 http://dx.doi.org/10.1186/1471-2431-12-140 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://bmcpediatr.biomedcentral.com/articles/10.1186/1471-2431-12-140 |