Amino Acid Requirements in Critically Ill Patients with Acute Kidney Injury Treated with Continuous Renal Replacement Therapy
Acute kidney injury in critically ill patients is often a complication of an underlying condition such as organ failure, sepsis, or drug therapy. In these patients, stress-induced hypercatabolism results in loss of body cell mass. Unless nutrition support is provided, malnutrition and negative nitro...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , |
| التنسيق: | article |
| منشور في: |
2008
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| الوصول للمادة أونلاين: | http://hdl.handle.net/10725/4512 http://dx.doi.org/10.1592/phco.28.5.600 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://onlinelibrary.wiley.com/doi/10.1592/phco.28.5.600/abstract |
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| _version_ | 1864513463709073408 |
|---|---|
| author | Btaiche, Imad F. |
| author2 | Mohammad, Rima A. Alaniz, Cesar Muller, Bruce A. |
| author2_role | author author author |
| author_facet | Btaiche, Imad F. Mohammad, Rima A. Alaniz, Cesar Muller, Bruce A. |
| author_role | author |
| dc.creator.none.fl_str_mv | Btaiche, Imad F. Mohammad, Rima A. Alaniz, Cesar Muller, Bruce A. |
| dc.date.none.fl_str_mv | 2008 2016-10-06T08:42:20Z 2016-10-06T08:42:20Z 2016-10-06 |
| dc.identifier.none.fl_str_mv | 0277-0008 http://hdl.handle.net/10725/4512 http://dx.doi.org/10.1592/phco.28.5.600 Btaiche, I. F., Mohammad, R. A., Alaniz, C., & Mueller, B. A. (2008). Amino acid requirements in critically ill patients with acute kidney injury treated with continuous renal replacement therapy. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 28(5), 600-613. http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://onlinelibrary.wiley.com/doi/10.1592/phco.28.5.600/abstract |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | Pharmacotherapy |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | Amino Acid Requirements in Critically Ill Patients with Acute Kidney Injury Treated with Continuous Renal Replacement Therapy |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Acute kidney injury in critically ill patients is often a complication of an underlying condition such as organ failure, sepsis, or drug therapy. In these patients, stress-induced hypercatabolism results in loss of body cell mass. Unless nutrition support is provided, malnutrition and negative nitrogen balance may ensue. Because of metabolic, fluid, and electrolyte abnormalities, optimization of nutrition to patients with acute kidney injury presents a challenge to the clinician. In patients treated with conventional intermittent hemodialysis, achieving adequate amino acid intake can be limited by azotemia and fluid restriction. With the use of continuous renal replacement therapy (CRRT), however, better control of azotemia and liberalization of fluid intake allow amino acid intake to be maximized to support the patient’s metabolic needs. High amino acid doses up to 2.5 g/kg/day in patients treated with CRRT improved nitrogen balance. However, to our knowledge, no studies have correlated increased amino acid intake with improved outcomes in critically ill patients with acute kidney injury. Data from large, prospective, randomized, controlled trials are needed to optimize the dosing of amino acids in critically ill patients with acute kidney injury who are treated with CRRT and to study the safety of high doses and their effects on patient morbidity and survival. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_367e2ff640654f3034f14c3d755c489d |
| identifier_str_mv | 0277-0008 Btaiche, I. F., Mohammad, R. A., Alaniz, C., & Mueller, B. A. (2008). Amino acid requirements in critically ill patients with acute kidney injury treated with continuous renal replacement therapy. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 28(5), 600-613. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/4512 |
| publishDate | 2008 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
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| spelling | Amino Acid Requirements in Critically Ill Patients with Acute Kidney Injury Treated with Continuous Renal Replacement TherapyBtaiche, Imad F.Mohammad, Rima A.Alaniz, CesarMuller, Bruce A.Acute kidney injury in critically ill patients is often a complication of an underlying condition such as organ failure, sepsis, or drug therapy. In these patients, stress-induced hypercatabolism results in loss of body cell mass. Unless nutrition support is provided, malnutrition and negative nitrogen balance may ensue. Because of metabolic, fluid, and electrolyte abnormalities, optimization of nutrition to patients with acute kidney injury presents a challenge to the clinician. In patients treated with conventional intermittent hemodialysis, achieving adequate amino acid intake can be limited by azotemia and fluid restriction. With the use of continuous renal replacement therapy (CRRT), however, better control of azotemia and liberalization of fluid intake allow amino acid intake to be maximized to support the patient’s metabolic needs. High amino acid doses up to 2.5 g/kg/day in patients treated with CRRT improved nitrogen balance. However, to our knowledge, no studies have correlated increased amino acid intake with improved outcomes in critically ill patients with acute kidney injury. Data from large, prospective, randomized, controlled trials are needed to optimize the dosing of amino acids in critically ill patients with acute kidney injury who are treated with CRRT and to study the safety of high doses and their effects on patient morbidity and survival.PublishedN/A2016-10-06T08:42:20Z2016-10-06T08:42:20Z20082016-10-06Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article0277-0008http://hdl.handle.net/10725/4512http://dx.doi.org/10.1592/phco.28.5.600Btaiche, I. F., Mohammad, R. A., Alaniz, C., & Mueller, B. A. (2008). Amino acid requirements in critically ill patients with acute kidney injury treated with continuous renal replacement therapy. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 28(5), 600-613.http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.phphttp://onlinelibrary.wiley.com/doi/10.1592/phco.28.5.600/abstractenPharmacotherapyinfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/45122021-03-19T10:00:52Z |
| spellingShingle | Amino Acid Requirements in Critically Ill Patients with Acute Kidney Injury Treated with Continuous Renal Replacement Therapy Btaiche, Imad F. |
| status_str | publishedVersion |
| title | Amino Acid Requirements in Critically Ill Patients with Acute Kidney Injury Treated with Continuous Renal Replacement Therapy |
| title_full | Amino Acid Requirements in Critically Ill Patients with Acute Kidney Injury Treated with Continuous Renal Replacement Therapy |
| title_fullStr | Amino Acid Requirements in Critically Ill Patients with Acute Kidney Injury Treated with Continuous Renal Replacement Therapy |
| title_full_unstemmed | Amino Acid Requirements in Critically Ill Patients with Acute Kidney Injury Treated with Continuous Renal Replacement Therapy |
| title_short | Amino Acid Requirements in Critically Ill Patients with Acute Kidney Injury Treated with Continuous Renal Replacement Therapy |
| title_sort | Amino Acid Requirements in Critically Ill Patients with Acute Kidney Injury Treated with Continuous Renal Replacement Therapy |
| url | http://hdl.handle.net/10725/4512 http://dx.doi.org/10.1592/phco.28.5.600 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://onlinelibrary.wiley.com/doi/10.1592/phco.28.5.600/abstract |