Chemical and microbiological investigations of metal ion interaction with norfloxacin
This report describes a spectrophotometric study on the interaction between norfloxacin (NFX) and metal ions (Al3+, Mg2+ and Ca2+). Two buffers of pH 3.6 and 8.8 were used. A shift in absorption maximum was observed and the stoichiometry of the complex was determined using the Job and molar methods....
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| Other Authors: | , , , |
| Format: | article |
| Published: |
1992
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| Online Access: | http://hdl.handle.net/10725/3568 http://dx.doi.org/10.1016/0378-5173(92)90229-U http://www.sciencedirect.com/science/article/pii/037851739290229U |
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| Summary: | This report describes a spectrophotometric study on the interaction between norfloxacin (NFX) and metal ions (Al3+, Mg2+ and Ca2+). Two buffers of pH 3.6 and 8.8 were used. A shift in absorption maximum was observed and the stoichiometry of the complex was determined using the Job and molar methods. The ratios were NFX:AL3+, 2:1 and 3:1 for the NFX:Mg2+ complex. The formation of a complex with Al3+ enhanced the water solubility of the drug. Microbiological studies indicated decreased activity of norfloxacin in the presence of metal ions. |
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