Chemical and microbiological investigations of metal ion interaction with norfloxacin
This report describes a spectrophotometric study on the interaction between norfloxacin (NFX) and metal ions (Al3+, Mg2+ and Ca2+). Two buffers of pH 3.6 and 8.8 were used. A shift in absorption maximum was observed and the stoichiometry of the complex was determined using the Job and molar methods....
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1992
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| Online Access: | http://hdl.handle.net/10725/3568 http://dx.doi.org/10.1016/0378-5173(92)90229-U http://www.sciencedirect.com/science/article/pii/037851739290229U |
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| _version_ | 1864513461634990080 |
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| author | Na'was, T. E. |
| author2 | Alkaysi, H. N. Abdel-Hay, M. H. Sheikh Salem, M. Gharaibeh, A. M. |
| author2_role | author author author author |
| author_facet | Na'was, T. E. Alkaysi, H. N. Abdel-Hay, M. H. Sheikh Salem, M. Gharaibeh, A. M. |
| author_role | author |
| dc.creator.none.fl_str_mv | Na'was, T. E. Alkaysi, H. N. Abdel-Hay, M. H. Sheikh Salem, M. Gharaibeh, A. M. |
| dc.date.none.fl_str_mv | 1992 2016-04-14T14:12:29Z 2016-04-14T14:12:29Z 2016-04-14 |
| dc.identifier.none.fl_str_mv | 0378-5173 http://hdl.handle.net/10725/3568 http://dx.doi.org/10.1016/0378-5173(92)90229-U Alkaysi, H. N., Abdel-Hay, M. H., Salem, M. S., Gharaibeh, A. M., & Na'was, T. E. (1992). Chemical and microbiological investigations of metal ion interaction with norfloxacin. International journal of pharmaceutics, 87(1), 73-77. http://www.sciencedirect.com/science/article/pii/037851739290229U |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | International Journal of Pharmaceutics |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | Chemical and microbiological investigations of metal ion interaction with norfloxacin |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | This report describes a spectrophotometric study on the interaction between norfloxacin (NFX) and metal ions (Al3+, Mg2+ and Ca2+). Two buffers of pH 3.6 and 8.8 were used. A shift in absorption maximum was observed and the stoichiometry of the complex was determined using the Job and molar methods. The ratios were NFX:AL3+, 2:1 and 3:1 for the NFX:Mg2+ complex. The formation of a complex with Al3+ enhanced the water solubility of the drug. Microbiological studies indicated decreased activity of norfloxacin in the presence of metal ions. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_36b776fb705366ade7ab54d384c0f19b |
| identifier_str_mv | 0378-5173 Alkaysi, H. N., Abdel-Hay, M. H., Salem, M. S., Gharaibeh, A. M., & Na'was, T. E. (1992). Chemical and microbiological investigations of metal ion interaction with norfloxacin. International journal of pharmaceutics, 87(1), 73-77. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/3568 |
| publishDate | 1992 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Chemical and microbiological investigations of metal ion interaction with norfloxacinNa'was, T. E.Alkaysi, H. N.Abdel-Hay, M. H.Sheikh Salem, M.Gharaibeh, A. M.This report describes a spectrophotometric study on the interaction between norfloxacin (NFX) and metal ions (Al3+, Mg2+ and Ca2+). Two buffers of pH 3.6 and 8.8 were used. A shift in absorption maximum was observed and the stoichiometry of the complex was determined using the Job and molar methods. The ratios were NFX:AL3+, 2:1 and 3:1 for the NFX:Mg2+ complex. The formation of a complex with Al3+ enhanced the water solubility of the drug. Microbiological studies indicated decreased activity of norfloxacin in the presence of metal ions.PublishedN/A2016-04-14T14:12:29Z2016-04-14T14:12:29Z19922016-04-14Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article0378-5173http://hdl.handle.net/10725/3568http://dx.doi.org/10.1016/0378-5173(92)90229-UAlkaysi, H. N., Abdel-Hay, M. H., Salem, M. S., Gharaibeh, A. M., & Na'was, T. E. (1992). Chemical and microbiological investigations of metal ion interaction with norfloxacin. International journal of pharmaceutics, 87(1), 73-77.http://www.sciencedirect.com/science/article/pii/037851739290229UenInternational Journal of Pharmaceuticsinfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/35682021-03-19T10:00:46Z |
| spellingShingle | Chemical and microbiological investigations of metal ion interaction with norfloxacin Na'was, T. E. |
| status_str | publishedVersion |
| title | Chemical and microbiological investigations of metal ion interaction with norfloxacin |
| title_full | Chemical and microbiological investigations of metal ion interaction with norfloxacin |
| title_fullStr | Chemical and microbiological investigations of metal ion interaction with norfloxacin |
| title_full_unstemmed | Chemical and microbiological investigations of metal ion interaction with norfloxacin |
| title_short | Chemical and microbiological investigations of metal ion interaction with norfloxacin |
| title_sort | Chemical and microbiological investigations of metal ion interaction with norfloxacin |
| url | http://hdl.handle.net/10725/3568 http://dx.doi.org/10.1016/0378-5173(92)90229-U http://www.sciencedirect.com/science/article/pii/037851739290229U |