Nicotine metabolism in healthy smokers and patients with cardiovascular diseases
In this study, we measured the excretion rate of nicotine and its two major metabolites, cotinine and trans-3′-hydroxycotinine (THOC), in the urine of 25 healthy smokers and 15 smokers who underwent a coronary artery bypass surgery or coronary angioplasty. After 1 day of smoking cessation, urine sam...
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2005
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| Online Access: | http://hdl.handle.net/10725/11114 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://link.springer.com/article/10.1007/s11010-005-8840-9 |
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| _version_ | 1864513488282451968 |
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| author | Chahine, Ramez |
| author2 | Abchee, Antoine Zalloua, Pierre |
| author2_role | author author |
| author_facet | Chahine, Ramez Abchee, Antoine Zalloua, Pierre |
| author_role | author |
| dc.creator.none.fl_str_mv | Chahine, Ramez Abchee, Antoine Zalloua, Pierre |
| dc.date.none.fl_str_mv | 2005 2019-07-22T07:15:57Z 2019-07-22T07:15:57Z 2019-07-22 |
| dc.identifier.none.fl_str_mv | 1573-4919 http://hdl.handle.net/10725/11114 Chahine, R., Abchee, A., & Zalloua, P. (2005). Nicotine metabolism in healthy smokers and patients with cardiovascular diseases. Molecular and cellular biochemistry, 280(1-2), 241-244. http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://link.springer.com/article/10.1007/s11010-005-8840-9 |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | Molecular and Cellular Biochemistry |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | Nicotine metabolism in healthy smokers and patients with cardiovascular diseases |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | In this study, we measured the excretion rate of nicotine and its two major metabolites, cotinine and trans-3′-hydroxycotinine (THOC), in the urine of 25 healthy smokers and 15 smokers who underwent a coronary artery bypass surgery or coronary angioplasty. After 1 day of smoking cessation, urine samples were collected in the morning, before smoking two cigarettes, and then three times after smoking, approximately 4 h apart. The results show that (i) in healthy smokers, nicotine and its two major metabolites were present at high concentration in the first urine sample after smoking, (ii) in smokers with cardiovascular disease nicotine and cotinine were less excreted whereas THOC was more excreted, mainly in the second urine sample. We conclude that this shift in nicotine metabolism may contribute to smoking-induced cardiovascular disease. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_38f1b11707cdce58ab369d7e09db0d55 |
| identifier_str_mv | 1573-4919 Chahine, R., Abchee, A., & Zalloua, P. (2005). Nicotine metabolism in healthy smokers and patients with cardiovascular diseases. Molecular and cellular biochemistry, 280(1-2), 241-244. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/11114 |
| publishDate | 2005 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
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| spelling | Nicotine metabolism in healthy smokers and patients with cardiovascular diseasesChahine, RamezAbchee, AntoineZalloua, PierreIn this study, we measured the excretion rate of nicotine and its two major metabolites, cotinine and trans-3′-hydroxycotinine (THOC), in the urine of 25 healthy smokers and 15 smokers who underwent a coronary artery bypass surgery or coronary angioplasty. After 1 day of smoking cessation, urine samples were collected in the morning, before smoking two cigarettes, and then three times after smoking, approximately 4 h apart. The results show that (i) in healthy smokers, nicotine and its two major metabolites were present at high concentration in the first urine sample after smoking, (ii) in smokers with cardiovascular disease nicotine and cotinine were less excreted whereas THOC was more excreted, mainly in the second urine sample. We conclude that this shift in nicotine metabolism may contribute to smoking-induced cardiovascular disease.PublishedN/A2019-07-22T07:15:57Z2019-07-22T07:15:57Z20052019-07-22Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1573-4919http://hdl.handle.net/10725/11114Chahine, R., Abchee, A., & Zalloua, P. (2005). Nicotine metabolism in healthy smokers and patients with cardiovascular diseases. Molecular and cellular biochemistry, 280(1-2), 241-244.http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.phphttps://link.springer.com/article/10.1007/s11010-005-8840-9enMolecular and Cellular Biochemistryinfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/111142021-03-19T10:47:35Z |
| spellingShingle | Nicotine metabolism in healthy smokers and patients with cardiovascular diseases Chahine, Ramez |
| status_str | publishedVersion |
| title | Nicotine metabolism in healthy smokers and patients with cardiovascular diseases |
| title_full | Nicotine metabolism in healthy smokers and patients with cardiovascular diseases |
| title_fullStr | Nicotine metabolism in healthy smokers and patients with cardiovascular diseases |
| title_full_unstemmed | Nicotine metabolism in healthy smokers and patients with cardiovascular diseases |
| title_short | Nicotine metabolism in healthy smokers and patients with cardiovascular diseases |
| title_sort | Nicotine metabolism in healthy smokers and patients with cardiovascular diseases |
| url | http://hdl.handle.net/10725/11114 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://link.springer.com/article/10.1007/s11010-005-8840-9 |