Transcription factor-7-like 2 gene variants are strongly associated with type 2 diabetes in Lebanese subjects

Transcription factor-7-like 2 gene variants are strongly associated with type 2 diabetes in Lebanese subjects

We tested the association of TCF7L2 variants with type 2 diabetes (T2DM) in 691 Lebanese people and 919 controls. rs7901695, rs4506565, rs7903146, rs12243326, rs7895340, and rs12255372 minor allele frequencies were higher in T2DM. Haplotype analysis (rs7901695–rs4506565–rs7903146–rs12243326–rs789534...

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Bibliographic Details
Main Author: Nemr, Rita (author)
Other Authors: Turki, Amira (author), Echtay, Akram (author), Al-Zaben, Ghadeer S. (author), Daher, Hoda S. (author), Irani-Hakime, Nora A. (author), Kelestian, Sose H. (author), Almawi, Wassim Y. (author)
Format: article
Published: 2012
Online Access:http://hdl.handle.net/10725/10694
https://doi.org/10.1016/j.diabres.2012.09.044
http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php
https://www.sciencedirect.com/science/article/pii/S0168822712003671
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Summary:We tested the association of TCF7L2 variants with type 2 diabetes (T2DM) in 691 Lebanese people and 919 controls. rs7901695, rs4506565, rs7903146, rs12243326, rs7895340, and rs12255372 minor allele frequencies were higher in T2DM. Haplotype analysis (rs7901695–rs4506565–rs7903146–rs12243326–rs7895340–rs11196205–rs12255372) identified positively- (2122112, 2222222) and negatively- (1111111) T2DM-associated haplotypes. TCF7L2 is a common T2DM candidate gene in Lebanese people.

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