Preparation and biological evaluation of novel acylhydrazide derivatives of 2,3-dichloronaphthoquinone
Naphthoquinones have been reported to possess a variety of pharmacological properties including antibacterial, antifungal, antiviral, anti-inflammatory, anti-artherosclerotic and anticancer effects. We have successfully synthesized a series of novel naphthoquinone acylhydrazides. The straightforward...
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2017
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| Online Access: | http://hdl.handle.net/10725/8398 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://www.researchgate.net/profile/Jomana_Elaridi/publication/317254349_Preparation_and_biological_evaluation_of_novel_acylhydrazide_derivatives_of_23-dichloronaphthoquinone/links/593c4f3d458515e398168db5/Preparation-and-biological-evaluation-of-novel-acylhydrazide-derivatives-of-2-3-dichloronaphthoquinone.pdf |
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| author | Elaridi, Jomana |
| author_facet | Elaridi, Jomana |
| author_role | author |
| dc.creator.none.fl_str_mv | Elaridi, Jomana |
| dc.date.none.fl_str_mv | 2017 2018-08-30T11:24:28Z 2018-08-30T11:24:28Z 2018-08-30 |
| dc.identifier.none.fl_str_mv | 1307-6175 http://hdl.handle.net/10725/8398 Elaridi, J., Karroum, N. B., Bouhadir, K., & Fatfat, M. (2017). Preparation and biological evaluation of novel acylhydrazide derivatives of 2, 3-dichloronaphthoquinone. Organic Communications, 10(2), 122. http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://www.researchgate.net/profile/Jomana_Elaridi/publication/317254349_Preparation_and_biological_evaluation_of_novel_acylhydrazide_derivatives_of_23-dichloronaphthoquinone/links/593c4f3d458515e398168db5/Preparation-and-biological-evaluation-of-novel-acylhydrazide-derivatives-of-2-3-dichloronaphthoquinone.pdf |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | Organic commincations |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | Preparation and biological evaluation of novel acylhydrazide derivatives of 2,3-dichloronaphthoquinone |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Naphthoquinones have been reported to possess a variety of pharmacological properties including antibacterial, antifungal, antiviral, anti-inflammatory, anti-artherosclerotic and anticancer effects. We have successfully synthesized a series of novel naphthoquinone acylhydrazides. The straightforward synthesis of these molecules involves a coupling reaction between 2,3-dichloro-1,4-naphthoquinone and several alkyl and aromatic hydrazides and the hydrazides of the pyrimidine nucleobases, uracil and thymine. The product hydrazides were isolated in good yields and completely characterized by spectroscopic analysis. Biological evaluation against human colon cancer HCT116 cells and human breast cancer MCF-7 cells indicated that the novel hydrazides possessed significant anticancer activity. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_3c527eaeae1de7beaac2424ea2484f4f |
| identifier_str_mv | 1307-6175 Elaridi, J., Karroum, N. B., Bouhadir, K., & Fatfat, M. (2017). Preparation and biological evaluation of novel acylhydrazide derivatives of 2, 3-dichloronaphthoquinone. Organic Communications, 10(2), 122. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/8398 |
| publishDate | 2017 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
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| spelling | Preparation and biological evaluation of novel acylhydrazide derivatives of 2,3-dichloronaphthoquinoneElaridi, JomanaNaphthoquinones have been reported to possess a variety of pharmacological properties including antibacterial, antifungal, antiviral, anti-inflammatory, anti-artherosclerotic and anticancer effects. We have successfully synthesized a series of novel naphthoquinone acylhydrazides. The straightforward synthesis of these molecules involves a coupling reaction between 2,3-dichloro-1,4-naphthoquinone and several alkyl and aromatic hydrazides and the hydrazides of the pyrimidine nucleobases, uracil and thymine. The product hydrazides were isolated in good yields and completely characterized by spectroscopic analysis. Biological evaluation against human colon cancer HCT116 cells and human breast cancer MCF-7 cells indicated that the novel hydrazides possessed significant anticancer activity.PublishedN/A2018-08-30T11:24:28Z2018-08-30T11:24:28Z20172018-08-30Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1307-6175http://hdl.handle.net/10725/8398Elaridi, J., Karroum, N. B., Bouhadir, K., & Fatfat, M. (2017). Preparation and biological evaluation of novel acylhydrazide derivatives of 2, 3-dichloronaphthoquinone. Organic Communications, 10(2), 122.http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.phphttps://www.researchgate.net/profile/Jomana_Elaridi/publication/317254349_Preparation_and_biological_evaluation_of_novel_acylhydrazide_derivatives_of_23-dichloronaphthoquinone/links/593c4f3d458515e398168db5/Preparation-and-biological-evaluation-of-novel-acylhydrazide-derivatives-of-2-3-dichloronaphthoquinone.pdfenOrganic commincationsinfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/83982021-03-19T10:43:17Z |
| spellingShingle | Preparation and biological evaluation of novel acylhydrazide derivatives of 2,3-dichloronaphthoquinone Elaridi, Jomana |
| status_str | publishedVersion |
| title | Preparation and biological evaluation of novel acylhydrazide derivatives of 2,3-dichloronaphthoquinone |
| title_full | Preparation and biological evaluation of novel acylhydrazide derivatives of 2,3-dichloronaphthoquinone |
| title_fullStr | Preparation and biological evaluation of novel acylhydrazide derivatives of 2,3-dichloronaphthoquinone |
| title_full_unstemmed | Preparation and biological evaluation of novel acylhydrazide derivatives of 2,3-dichloronaphthoquinone |
| title_short | Preparation and biological evaluation of novel acylhydrazide derivatives of 2,3-dichloronaphthoquinone |
| title_sort | Preparation and biological evaluation of novel acylhydrazide derivatives of 2,3-dichloronaphthoquinone |
| url | http://hdl.handle.net/10725/8398 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://www.researchgate.net/profile/Jomana_Elaridi/publication/317254349_Preparation_and_biological_evaluation_of_novel_acylhydrazide_derivatives_of_23-dichloronaphthoquinone/links/593c4f3d458515e398168db5/Preparation-and-biological-evaluation-of-novel-acylhydrazide-derivatives-of-2-3-dichloronaphthoquinone.pdf |