Metformin treatment inhibits motility and invasion of glioblastoma cancer cells
Glioblastoma multiforme (GBM) is one of the most common and deadliest cancers of the central nervous system (CNS). GBMs high ability to infiltrate healthy brain tissues makes it difficult to remove surgically and account for its fatal outcomes. To improve the chances of survival, it is critical to s...
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| مؤلفون آخرون: | , , , , , , |
| التنسيق: | article |
| منشور في: |
2018
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| الوصول للمادة أونلاين: | http://hdl.handle.net/10725/11397 https://doi.org/10.1155/2018/5917470 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://www.hindawi.com/journals/acp/2018/5917470/abs/ |
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| _version_ | 1864513488715513856 |
|---|---|
| author | Al Hassan, Marwa |
| author2 | Fakhoury, Isabelle El Masri, Zeinab Ghazale, Noura Dennaoui, Rayane El Atat, Oula Kanaan, Amjad El-Sibai, Mirvat |
| author2_role | author author author author author author author |
| author_facet | Al Hassan, Marwa Fakhoury, Isabelle El Masri, Zeinab Ghazale, Noura Dennaoui, Rayane El Atat, Oula Kanaan, Amjad El-Sibai, Mirvat |
| author_role | author |
| dc.creator.none.fl_str_mv | Al Hassan, Marwa Fakhoury, Isabelle El Masri, Zeinab Ghazale, Noura Dennaoui, Rayane El Atat, Oula Kanaan, Amjad El-Sibai, Mirvat |
| dc.date.none.fl_str_mv | 2018 2019-10-08T12:44:05Z 2019-10-08T12:44:05Z 2019-10-08 |
| dc.identifier.none.fl_str_mv | 2210-7185 http://hdl.handle.net/10725/11397 https://doi.org/10.1155/2018/5917470 Al Hassan, M., Fakhoury, I., El Masri, Z., Ghazale, N., Dennaoui, R., El Atat, O., ... & El-Sibai, M. (2018). Metformin treatment inhibits motility and invasion of glioblastoma cancer cells. Analytical Cellular Pathology, 2018. http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://www.hindawi.com/journals/acp/2018/5917470/abs/ |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | Analytical Cellular Pathology |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | Metformin treatment inhibits motility and invasion of glioblastoma cancer cells |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Glioblastoma multiforme (GBM) is one of the most common and deadliest cancers of the central nervous system (CNS). GBMs high ability to infiltrate healthy brain tissues makes it difficult to remove surgically and account for its fatal outcomes. To improve the chances of survival, it is critical to screen for GBM-targeted anticancer agents with anti-invasive and antimigratory potential. Metformin, a commonly used drug for the treatment of diabetes, has recently emerged as a promising anticancer molecule. This prompted us, to investigate the anticancer potential of metformin against GBMs, specifically its effects on cell motility and invasion. The results show a significant decrease in the survival of SF268 cancer cells in response to treatment with metformin. Furthermore, metformin’s efficiency in inhibiting 2D cell motility and cell invasion in addition to increasing cellular adhesion was also demonstrated in SF268 and U87 cells. Finally, AKT inactivation by downregulation of the phosphorylation level upon metformin treatment was also evidenced. In conclusion, this study provides insights into the anti-invasive antimetastatic potential of metformin as well as its underlying mechanism of action. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_3fcaff5c7a3d8144f714a08aa1b280b7 |
| identifier_str_mv | 2210-7185 Al Hassan, M., Fakhoury, I., El Masri, Z., Ghazale, N., Dennaoui, R., El Atat, O., ... & El-Sibai, M. (2018). Metformin treatment inhibits motility and invasion of glioblastoma cancer cells. Analytical Cellular Pathology, 2018. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/11397 |
| publishDate | 2018 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Metformin treatment inhibits motility and invasion of glioblastoma cancer cellsAl Hassan, MarwaFakhoury, IsabelleEl Masri, ZeinabGhazale, NouraDennaoui, RayaneEl Atat, OulaKanaan, AmjadEl-Sibai, MirvatGlioblastoma multiforme (GBM) is one of the most common and deadliest cancers of the central nervous system (CNS). GBMs high ability to infiltrate healthy brain tissues makes it difficult to remove surgically and account for its fatal outcomes. To improve the chances of survival, it is critical to screen for GBM-targeted anticancer agents with anti-invasive and antimigratory potential. Metformin, a commonly used drug for the treatment of diabetes, has recently emerged as a promising anticancer molecule. This prompted us, to investigate the anticancer potential of metformin against GBMs, specifically its effects on cell motility and invasion. The results show a significant decrease in the survival of SF268 cancer cells in response to treatment with metformin. Furthermore, metformin’s efficiency in inhibiting 2D cell motility and cell invasion in addition to increasing cellular adhesion was also demonstrated in SF268 and U87 cells. Finally, AKT inactivation by downregulation of the phosphorylation level upon metformin treatment was also evidenced. In conclusion, this study provides insights into the anti-invasive antimetastatic potential of metformin as well as its underlying mechanism of action.PublishedN/A2019-10-08T12:44:05Z2019-10-08T12:44:05Z20182019-10-08Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2210-7185http://hdl.handle.net/10725/11397https://doi.org/10.1155/2018/5917470Al Hassan, M., Fakhoury, I., El Masri, Z., Ghazale, N., Dennaoui, R., El Atat, O., ... & El-Sibai, M. (2018). Metformin treatment inhibits motility and invasion of glioblastoma cancer cells. Analytical Cellular Pathology, 2018.http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.phphttps://www.hindawi.com/journals/acp/2018/5917470/abs/enAnalytical Cellular Pathologyinfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/113972021-03-19T10:47:37Z |
| spellingShingle | Metformin treatment inhibits motility and invasion of glioblastoma cancer cells Al Hassan, Marwa |
| status_str | publishedVersion |
| title | Metformin treatment inhibits motility and invasion of glioblastoma cancer cells |
| title_full | Metformin treatment inhibits motility and invasion of glioblastoma cancer cells |
| title_fullStr | Metformin treatment inhibits motility and invasion of glioblastoma cancer cells |
| title_full_unstemmed | Metformin treatment inhibits motility and invasion of glioblastoma cancer cells |
| title_short | Metformin treatment inhibits motility and invasion of glioblastoma cancer cells |
| title_sort | Metformin treatment inhibits motility and invasion of glioblastoma cancer cells |
| url | http://hdl.handle.net/10725/11397 https://doi.org/10.1155/2018/5917470 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://www.hindawi.com/journals/acp/2018/5917470/abs/ |